Longevity Map
Goal → Mechanism → Ingredient → Product → Study.
Follow one thread from a health goal to the published study behind it. Pick a biomarker, see the mechanisms, the molecules that target them, the products on the market, and the evidence. No longevity site maps the full chain.
Pick a level to start
1 · Goal
Biomarkers you track
25-Hydroxyvitamin D (Vitamin D Status)The standard blood test for vitamin D status; correcting deficiency matters…Open →
Apolipoprotein B (ApoB)The structural protein on every atherogenic lipoprotein particle, directly…Open →
Body Composition (Fat Mass, Lean Mass, Visceral Fat)The muscle-to-fat and fat-distribution profile of the body, where the…Open →
Carotid Intima-Media Thickness (IMT)An ultrasound measurement of carotid artery wall thickness used as a marker…Open →
Coronary Artery Calcium (CAC) ScoreA CT scan measurement of calcified coronary plaque that directly images…Open →
DunedinPACE (Pace of Aging Clock)A DNA methylation measure of the current rate of biological aging, built from…Open →
GlycanAge (IgG Glycosylation Age)A commercial biological-age test based on antibody sugar-chain patterns…Open →
GrimAge (DNAm GrimAge Epigenetic Clock)A second-generation epigenetic clock trained directly on mortality data that…Open →
HDL Cholesterol (HDL-C)Cholesterol carried by high-density lipoprotein particles, historically…Open →
HbA1c (Glycated Hemoglobin)A blood test reflecting average glucose exposure over 2-3 months, used to…Open →
Heart Rate Variability (HRV)The beat-to-beat variation in heart timing reflecting autonomic nervous…Open →
Horvath Clock (DNA Methylation Age)The first widely used epigenetic clock estimates biological age from DNA…Open →
NAD+ (Blood/Tissue Levels)A cellular energy coenzyme that declines with age in multiple tissues; NR and…Open →
PhenoAge (DNAm PhenoAge Epigenetic Clock)A second-generation epigenetic clock built from nine clinical mortality…Open →
Proteomic Aging Clock (Organ-Specific)A blood proteomics-based biological age score built from ~3,000…Open →
Resting Heart Rate (RHR)The number of heartbeats per minute at rest; higher values and rising trends…Open →
Retinal Age (Deep-Learning Fundus Photography)A deep-learning biological age score derived from a standard retinal fundus…Open →
Telomere Length (Leukocyte)A modest, consistent predictor of mortality across large pooled cohorts, but…Open →
Tumor Necrosis Factor-alpha (TNF-alpha)A pro-inflammatory cytokine with mortality associations that shift…Open →
VO2max (Maximal Oxygen Uptake)The gold-standard measure of cardiorespiratory fitness; higher VO2max…Open →
hs-CRP (High-Sensitivity C-Reactive Protein)A sensitive blood marker of low-grade systemic inflammation that…Open →
2 · Mechanism
Biological pathway
AMPK ActivationAMP-activated protein kinase senses low cellular energy and switches on…HallmarkOpen →
Altered Intercellular CommunicationAging shifts how cells signal to each other, through hormones, the…HallmarkOpen →
AutophagyAutophagy is the cell's recycling system for damaged proteins and organelles…HallmarkOpen →
DNA Damage Response and Genomic InstabilityDNA sustains tens of thousands of damaging events per cell per day, and the…HallmarkOpen →
Deregulated Nutrient SensingThe body's core nutrient-sensing pathways (insulin/IGF-1, mTOR, AMPK…HallmarkOpen →
Epigenetic DriftDNA methylation patterns become progressively noisier and less predictable…HallmarkOpen →
FOXO Longevity Transcription FactorsFOXO transcription factors switch on stress-resistance and repair genes when…HallmarkOpen →
Hallmarks of AgingA framework of twelve interconnected cellular processes, first proposed in…HallmarkOpen →
InflammagingChronic, low-grade inflammation rises with age even without infection, and it…HallmarkOpen →
Insulin/IGF-1 Signaling in AgingThe insulin/IGF-1 signaling pathway couples nutrient availability to growth…HallmarkOpen →
Mitochondrial BiogenesisPGC-1alpha-driven mitochondrial biogenesis declines with age, and exercise…HallmarkOpen →
Oxidative Stress and the Free Radical TheoryReactive oxygen species damage cellular components with age, but the…Open →
Proteostasis CollapseThe cellular quality-control systems that fold, refold, and clear proteins…HallmarkOpen →
Senescence ClearanceSenescent cells stop dividing but refuse to die, secrete inflammatory…HallmarkOpen →
Sirtuin ActivationSirtuins are NAD-dependent deacetylases that link nutrient status to DNA…HallmarkOpen →
Stem Cell ExhaustionAdult stem cell pools shrink and lose regenerative capacity with age, slowing…HallmarkOpen →
Telomere AttritionTelomeres, the repetitive DNA caps on chromosomes, shorten with each cell…HallmarkOpen →
mTOR SignalingMechanistic target of rapamycin (mTOR) couples nutrient and growth-factor…HallmarkOpen →
p53 Tumor Suppressor Pathwayp53 stops damaged cells from dividing to prevent cancer, but constitutively…HallmarkOpen →
3 · Ingredient
Molecule / compound
4 · Product
Supplements on the market
Select an ingredient
5 · Study
Published evidence
Select an ingredient