Akkermansia · Akkermansia muciniphila
Gut bacterium linked to leanness and metabolic health. One human trial — pasteurized, overweight adults, positive metabolic signals.
Short answer
Akkermansia (Akkermansia muciniphila) is a microbiome with evidence grade C, meaning it is backed by mixed or small human trials. We track 0 produkter containing Akkermansia. The top-ranked product scores 0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $0.00 per månad.
What it is
A bacterium that lives in the mucus layer of your gut. Lean, metabolically healthy people tend to carry more of it. Now sold as a live or pasteurized supplement.
Why people take it
The key human trial (Depommier et al., Nature Medicine 2019) gave pasteurized Akkermansia to overweight adults for 3 months. It was safe and produced modest improvements in insulin sensitivity and cholesterol compared to placebo. One trial, one research group, modest effects.
Our verdict
The most scientifically interesting 'next-gen probiotic', with exactly one human trial behind it. Early days.
Structure & class
Mucin-degrading anaerobe, Verrucomicrobiota. Pasteurized (heat-killed) form showed superior metabolic effects to live form in the pivotal trial; membrane protein Amuc_1100 implicated.
Mechanism & clinical data
Depommier et al. 2019 (Nat Med) RCT (n=40, overweight/obese insulin-resistant adults): pasteurized A. muciniphila for 3 months improved insulin sensitivity (~28% vs placebo), reduced insulinemia and plasma cholesterol, safe and well tolerated. Replication in independent populations is pending.
Pharmacokinetics
Bacterial colonization dynamics; not a mg-dosed molecule.
Dose & forms
What to watch out for
The positive trial used pasteurized bacteria at 10^10 cells/day — a dose count, not mg. Produkter citing the trial but selling live cultures at different counts are extrapolating.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Akkermansia, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU authorizes pasteurized Akkermansia muciniphila as Novel FoodThe European Commission authorized pasteurized Akkermansia muciniphila as a Novel Food, making it the first next-generation probiotic bacterium to receive EU authorization. Live (non-pasteurized) cells require separate authorization.
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Depommier et al. 2019 (Nature Medicine)First-in-human RCT (n=40): pasteurized Akkermansia for 3 months improved insulin sensitivity and reduced cholesterol vs placebo in overweight/obese adults; safe and well tolerated.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Depommier et al. 2019 (Nature Medicine)
First-in-human RCT (n=40): pasteurized Akkermansia for 3 months improved insulin sensitivity and reduced cholesterol vs placebo in overweight/obese adults; safe and well tolerated.
Läs studie →
Found in these produkter
Alla produkter in our catalog that contain Akkermansia, ranked by our overall score. Ranking is editorial, never paid.
No produkter in our catalog contain this yet.
Buying guides and comparisons
Related ingredients
Se alla in Microbiome →Molekyler in the same class, plus the actives most often formulated alongside Akkermansia in our catalogue.
Frequently asked questions
What is Akkermansia?
A bacterium that lives in the mucus layer of your gut. Lean, metabolically healthy people tend to carry more of it. Now sold as a live or pasteurized supplement.
What dose of Akkermansia should I take?
The trial dose in published human studies is None mg per dag, with a range of None to None mg per dag. Always consult a qualified clinician before starting any supplement.
Is Akkermansia safe?
The positive trial used pasteurized bacteria at 10^10 cells/day — a dose count, not mg. Produkter citing the trial but selling live cultures at different counts are extrapolating.
What is the best Akkermansia supplement?
We track 0 produkter containing Akkermansia. The top-ranked product scores 0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Akkermansia?
Akkermansia has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.