Apigenin · Apigenin (4',5,7-trihydroxyflavone)
A plant flavonoid that may slow the age-related NAD+ drain by inhibiting the CD38 enzyme.
Short answer
Apigenin (Apigenin (4',5,7-trihydroxyflavone)) is a flavonoid / cd38 inhibitor with evidence grade D, meaning it is primarily supported by animal studies. We track 3 produkter containing Apigenin. Typical doses range from 50.0 to 250.0 mg per portion. The top-ranked product scores 5.8 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $55.00 per månad.
Top Apigenin produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Apigenin Supplement | 50.0 mg | $24.95 | Yes | 5.8 | |
| Senolytic Activator | 50.0 mg | $19.89 | Yes | 5.5 | |
| Pure Apigenin | 250.0 mg | $55.00 | Yes | 4.7 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Apigenin is a flavonoid found in parsley, chamomile, celery, and grapefruit. In cell studies it blocks an enzyme called CD38 that consumes NAD+ as we age.
Why people take it
The theory: less CD38 activity means less NAD+ destruction, so your NAD+ pool stays higher for longer. Direct human trials on aging endpoints are not yet available; most evidence is preclinical or mechanistic.
Our verdict
Biologically interesting but human evidence is thin. Very safe at supplement doses (50 to 500 mg/day). Reasonable as a low-cost add-on to a NAD+ strategy, not a lead actor.
Structure & class
4',5,7-Trihydroxyflavone. Non-competitive CD38 inhibitor; also modulates NF-κB, mTOR, and estrogen receptor β signalling in vitro.
Mechanism & clinical data
Preclinical data (Escande 2013; Chini 2020) show CD38 inhibition and elevated NAD+ in mouse tissues. Senolytic activity demonstrated in vitro alongside fisetin/quercetin. No published human RCT on healthspan endpoints as of 2026.
Pharmacokinetics
~90 min in humans; low oral bioavailability.
Dose & forms
What to watch out for
Bioavailability is low without a fat carrier or phytosome form; grapefruit-derived apigenin retains CYP3A4 interaction risk.
Säkerhet limits and interactions
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Apigenin, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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Chini et al. 2020 (Cell Metabolism)CD38 identified as major NAD+ase driving NAD+ decline with aging, pharmacological CD38 inhibition (including flavonoids like apigenin) reversed tissue NAD+ loss in mice.
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Escande et al. 2013 (Diabetes)Apigenin inhibited CD38 in vitro and raised NAD+ in mouse tissues, improving metabolic markers.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Escande et al. 2013 (Diabetes)
Apigenin inhibited CD38 in vitro and raised NAD+ in mouse tissues, improving metabolic markers.
Läs studie → -
Chini et al. 2020 (Cell Metabolism)
CD38 identified as major NAD+ase driving NAD+ decline with aging, pharmacological CD38 inhibition (including flavonoids like apigenin) reversed tissue NAD+ loss in mice.
Läs studie →
Found in these produkter (3)
Alla produkter in our catalog that contain Apigenin, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Flavonoid / CD38 inhibitor →Molekyler in the same class, plus the actives most often formulated alongside Apigenin in our catalogue.
Frequently asked questions
What is Apigenin?
Apigenin is a flavonoid found in parsley, chamomile, celery, and grapefruit. In cell studies it blocks an enzyme called CD38 that consumes NAD+ as we age.
What dose of Apigenin should I take?
The trial dose in published human studies is 50 mg per dag, with a range of 25 to 500 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Apigenin safe?
Bioavailability is low without a fat carrier or phytosome form; grapefruit-derived apigenin retains CYP3A4 interaction risk.
What is the best Apigenin supplement?
We track 3 produkter containing Apigenin. The top-ranked product scores 5.8 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Apigenin?
Apigenin has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.