C15:0 · Pentadecanoic Acid (C15:0)
Odd-chain saturated fat from dairy, proposed as a new essential fatty acid. Biomarker data is good; outcome trials are just starting.
Short answer
C15:0 (Pentadecanoic Acid (C15:0)) is a metabolic with evidence grade D, meaning it is primarily supported by animal studies. We track 2 produkter containing C15:0. Typical doses range from 100 to 100 mg per portion. The top-ranked product scores 5.2 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $149.95 per månad.
Top C15:0 produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Fatty15 Daily Cellular Support (C15:0) | 100 mg | $149.95 | Yes | 5.2 | |
| Healthy Aging Gummies | 100 mg | $79.95 | Yes | 4.4 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
A saturated fat found in trace amounts in butter and whole milk. Higher blood levels track with lower diabetes and heart disease risk in population studies. Now sold as a purified supplement.
Why people take it
Dolphins taught the researchers: Navy dolphins with higher C15:0 stayed healthier, and feeding them more fixed their metabolic markers. In humans, blood C15:0 consistently predicts better metabolic health — but those are correlations, and the outcome trials in people are still underway.
Our verdict
The most interesting new fatty acid in years, with human outcome data still catching up. Watch this space rather than mortgage the house.
Structure & class
Pentadecanoic acid, odd-chain saturated fatty acid. Proposed PPAR-α/δ and AMPK modulator; candidate 'essential' fatty acid (Venn-Watson & Schork).
Mechanism & clinical data
Venn-Watson et al. 2020 (Sci Rep): in dolphins, higher dietary C15:0 reversed elevated liver enzymes, insulin, and ferritin. Human cohort studies (Framingham, Cardiovascular Health Studie) associate circulating C15:0 with lower risks of type 2 diabetes and cardiovascular disease. A 2023 analysis argued C15:0 meets criteria for an essential fatty acid. Randomized human outcome trials are registered but not yet published.
Pharmacokinetics
Incorporated into circulating lipids; steady state over weeks.
Dose & forms
What to watch out for
The healthiest cohorts get C15:0 from dairy fat — the supplement story assumes the molecule, not the milk matrix, is the active agent. That assumption is untested in human trials.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for C15:0, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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C15:0 as candidate essential fatty acid (2023)Scientific argument paper: C15:0 fulfills published criteria for an essential fatty acid, based on dose-dependent cellular activities and population deficiency signals.
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Venn-Watson et al. 2020 (Sci Rep)Dolphin intervention + in vitro: dietary C15:0 improved metabolic and hematologic markers; mechanistic assays showed dose-dependent PPAR and anti-inflammatory activity across human cell systems.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Venn-Watson et al. 2020 (Sci Rep)
Dolphin intervention + in vitro: dietary C15:0 improved metabolic and hematologic markers; mechanistic assays showed dose-dependent PPAR and anti-inflammatory activity across human cell systems.
Läs studie → -
C15:0 as candidate essential fatty acid (2023)
Scientific argument paper: C15:0 fulfills published criteria for an essential fatty acid, based on dose-dependent cellular activities and population deficiency signals.
Läs studie →
Found in these produkter (2)
Alla produkter in our catalog that contain C15:0, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Metabolic →Molekyler in the same class, plus the actives most often formulated alongside C15:0 in our catalogue.
Frequently asked questions
What is C15:0?
A saturated fat found in trace amounts in butter and whole milk. Higher blood levels track with lower diabetes and heart disease risk in population studies. Now sold as a purified supplement.
What dose of C15:0 should I take?
The trial dose in published human studies is 100 mg per dag, with a range of 100 to 200 mg per dag. Always consult a qualified clinician before starting any supplement.
Is C15:0 safe?
The healthiest cohorts get C15:0 from dairy fat — the supplement story assumes the molecule, not the milk matrix, is the active agent. That assumption is untested in human trials.
What is the best C15:0 supplement?
We track 2 produkter containing C15:0. The top-ranked product scores 5.2 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for C15:0?
C15:0 has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.