Calcium · Calcium (citrate/carbonate)
Bone mineral, but excess supplementation may harm arteries.
Short answer
Calcium (Calcium (citrate/carbonate)) is a foundational with evidence grade B, meaning it is supported by human RCTs. We track 4 produkter containing Calcium. Typical doses range from 125 to 400.0 mg per portion. The top-ranked product scores 7.2 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $72.00 per månad.
Top Calcium produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Ca-AKG (Calcium Alpha-Ketoglutarate) | 400.0 mg | $49.00 | Yes | 7.2 | |
| Vital Proteins Bioactive Collagen Complex Bone & Joint Support | 250.0 mg | $59.00 | Yes | 6.5 | |
| Advanced Nutrients | 125 mg | $72.00 | Yes | 6.3 | |
| Calcium AKG 1500 | 200 mg | $24.97 | Yes | 5.7 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Bone mineral. Best from diet (dairy, greens); supplements a fallback.
Why people take it
Correcting deficiency prevents osteoporosis; high-dose supplements linked to cardiovascular risk.
Our verdict
Get from diet. If supplementing, pair with K2 and stay <500 mg per dose.
Structure & class
Divalent cation; citrate more soluble than carbonate.
Mechanism & clinical data
Bolland 2010 metaanalys raised concerns about CV risk.
Pharmacokinetics
Slow bone turnover.
Dose & forms
What to watch out for
Pair with vitamin K2 and D3.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Calcium, most recent first. Every entry links to its primär source.
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Health Enthusiast Cohort 2026 (Aging Cell)In a cross-sectional cohort of 4,260 health enthusiasts, a delayed-release calcium-alpha-ketoglutarate plus vitamin supplement was associated with a 1.8-year lower biological age residual, an effect not seen with regular (non-delayed-release) AKG.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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ABLE Trial Protocol 2023 (GeroScience)This registered 120-person, dubbelblind, placebokontrollerad RCT protocol tests whether 6 months of 1g/day sustained-release Ca-AKG reduces DNA methylation age in adults with accelerated biological aging (NCT05706389).
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Rejuvant 2021 (Aging, 8-year bio age reduction)A retrospective analysis of 42 individuals taking a Ca-AKG-based formulation for an average of 7 months found an average 8-year reduction in DNA methylation age.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
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Ca-AKG PhenoAge RCT (NCT07114536)This ongoing randomized, dubbelblind, placebokontrollerad trial is evaluating whether 12 weeks of Ca-AKG supplementation changes PhenoAge biological age and other aging biomarkers in adults aged 40-75.
Landmark studies
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Rejuvant 2021 (Aging, 8-year bio age reduction)
A retrospective analysis of 42 individuals taking a Ca-AKG-based formulation for an average of 7 months found an average 8-year reduction in DNA methylation age.
Läs studie → -
ABLE Trial Protocol 2023 (GeroScience)
This registered 120-person, dubbelblind, placebokontrollerad RCT protocol tests whether 6 months of 1g/day sustained-release Ca-AKG reduces DNA methylation age in adults with accelerated biological aging (NCT05706389).
Läs studie → -
Health Enthusiast Cohort 2026 (Aging Cell)
In a cross-sectional cohort of 4,260 health enthusiasts, a delayed-release calcium-alpha-ketoglutarate plus vitamin supplement was associated with a 1.8-year lower biological age residual, an effect not seen with regular (non-delayed-release) AKG.
Läs studie → -
Ca-AKG PhenoAge RCT (NCT07114536)
This ongoing randomized, dubbelblind, placebokontrollerad trial is evaluating whether 12 weeks of Ca-AKG supplementation changes PhenoAge biological age and other aging biomarkers in adults aged 40-75.
Läs studie →
Found in these produkter (4)
Alla produkter in our catalog that contain Calcium, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Foundational →Molekyler in the same class, plus the actives most often formulated alongside Calcium in our catalogue.
Frequently asked questions
What is Calcium?
Bone mineral. Best from diet (dairy, greens); supplements a fallback.
What dose of Calcium should I take?
The trial dose in published human studies is 500 mg per dag, with a range of 500 to 1200 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Calcium safe?
Pair with vitamin K2 and D3.
What is the best Calcium supplement?
We track 4 produkter containing Calcium. The top-ranked product scores 7.2 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Calcium?
Calcium has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.