D-Ribose · D-Ribose
Sugar that feeds ATP production. Chronic-fatigue community favorite with one uncontrolled pilot study behind it.
Short answer
D-Ribose (D-Ribose) is a mitochondrial with evidence grade D, meaning it is primarily supported by animal studies. We track 0 produkter containing D-Ribose. The top-ranked product scores 0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $0.00 per månad.
What it is
A five-carbon sugar your cells use to build ATP, the energy currency. The idea: more ribose, faster energy recovery in struggling cells.
Why people take it
One frequently cited 2006 pilot study reported that people with chronic fatigue syndrome and fibromyalgia felt much better on ribose. It had no placebo group and 41 participants. Cardiac imaging studies show faster ATP recovery in heart failure patients, which is mechanistically interesting but not an outcome.
Our verdict
A real mechanism with anecdote-grade clinical evidence. If you have CFS and try it, run your own n=1 honestly.
Structure & class
Pentose sugar, rate-limiting substrate for purine nucleotide synthesis via the pentose phosphate pathway.
Mechanism & clinical data
Teitelbaum et al. 2006 (J Altern Complement Med) uncontrolled pilot (n=41, CFS/fibromyalgia): 5 g three times daily, 66% of patients reported significant improvement in energy and well-being — no control arm. Cardiac studies show ribose accelerates myocardial ATP recovery post-ischemia. No placebokontrollerad trial has tested the CFS claims.
Pharmacokinetics
Rapidly absorbed and metabolized; dosed 2-3 times daily.
Dose & forms
What to watch out for
The famous pilot study is uncontrolled — placebo response in CFS trials runs 30-40%. Can lower blood sugar slightly; caution with diabetes medication.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for D-Ribose, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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Teitelbaum et al. 2006 (CFS/fibromyalgia pilot)Uncontrolled pilot (n=41): D-ribose 15 g/day associated with self-reported improvements in energy, sleep and well-being in 66% of CFS/FM patients. No placebo group — interpret with caution.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Teitelbaum et al. 2006 (CFS/fibromyalgia pilot)
Uncontrolled pilot (n=41): D-ribose 15 g/day associated with self-reported improvements in energy, sleep and well-being in 66% of CFS/FM patients. No placebo group — interpret with caution.
Läs studie →
Found in these produkter
Alla produkter in our catalog that contain D-Ribose, ranked by our overall score. Ranking is editorial, never paid.
No produkter in our catalog contain this yet.
Buying guides and comparisons
Related ingredients
Se alla in Mitochondrial →Molekyler in the same class, plus the actives most often formulated alongside D-Ribose in our catalogue.
Frequently asked questions
What is D-Ribose?
A five-carbon sugar your cells use to build ATP, the energy currency. The idea: more ribose, faster energy recovery in struggling cells.
What dose of D-Ribose should I take?
The trial dose in published human studies is 5000 mg per dag, with a range of 5000 to 15000 mg per dag. Always consult a qualified clinician before starting any supplement.
Is D-Ribose safe?
The famous pilot study is uncontrolled — placebo response in CFS trials runs 30-40%. Can lower blood sugar slightly; caution with diabetes medication.
What is the best D-Ribose supplement?
We track 0 produkter containing D-Ribose. The top-ranked product scores 0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for D-Ribose?
D-Ribose has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.