Folate (5-MTHF) · L-methylfolate
The active form of folate; better for those with MTHFR variants.
Short answer
Folate (5-MTHF) (L-methylfolate) is a foundational with evidence grade B, meaning it is supported by human RCTs. We track 4 produkter containing Folate (5-MTHF). Typical doses range from 0.4 to 1.333 mg per portion. The top-ranked product scores 7.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $40.00 per månad.
Top Folate (5-MTHF) produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Matter | 1.333 mg | $40.00 | Yes | 7.3 | |
| Jarrow Formulas Methyl Folate, 400 mcg | 0.4 mg | $11.99 | No | 7.2 | |
| Vital Proteins Beauty Boost Capsules | 0.4 mg | $30.00 | No | 5.8 | |
| Seed AM-02 Energy + Focus | 0.4 mg | $34.99 | Yes | 5.4 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
A B-vitamin essential for DNA synthesis and methylation. Different from cheap 'folic acid', L-methylfolate is the biologically active form.
Why people take it
Corrects deficiency, essential in pregnancy. High folic acid in supplements can build up in blood as unmetabolized folic acid; methylfolate doesn't.
Our verdict
Pay a bit extra for L-methylfolate over folic acid, especially over 40 or if you don't tolerate folic acid.
Structure & class
(6S)-5-methyltetrahydrofolate.
Mechanism & clinical data
Bypasses MTHFR polymorphism. Immediately usable in the methylation cycle.
Pharmacokinetics
Days.
Dose & forms
What to watch out for
Folic acid (the synthetic form) can mask B12 deficiency. Choose methylfolate.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Folate (5-MTHF), most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
Found in these produkter (4)
Alla produkter in our catalog that contain Folate (5-MTHF), ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Foundational →Molekyler in the same class, plus the actives most often formulated alongside Folate (5-MTHF) in our catalogue.
Frequently asked questions
What is Folate (5-MTHF)?
A B-vitamin essential for DNA synthesis and methylation. Different from cheap 'folic acid', L-methylfolate is the biologically active form.
What dose of Folate (5-MTHF) should I take?
The trial dose in published human studies is 0.4 mg per dag, with a range of 0.2 to 1 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Folate (5-MTHF) safe?
Folic acid (the synthetic form) can mask B12 deficiency. Choose methylfolate.
What is the best Folate (5-MTHF) supplement?
We track 4 produkter containing Folate (5-MTHF). The top-ranked product scores 7.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Folate (5-MTHF)?
Folate (5-MTHF) has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.