Glutathione · Reduced Glutathione (liposomal)
Direct antioxidant supplement; only liposomal really raises blood levels.
Short answer
Glutathione (Reduced Glutathione (liposomal)) is a antioxidant with evidence grade C, meaning it is backed by mixed or small human trials. We track 4 produkter containing Glutathione. Typical doses range from 130.0 to 500 mg per portion. The top-ranked product scores 6.4 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $67.50 per månad.
Top Glutathione produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Ultimate Omega + Curcumin | 150.0 mg | $51.95 | Yes | 6.4 | |
| Unlimit Liposomal Glutathione | 500 mg | $39.99 | No | 5.6 | |
| Liposomal Glutathione | 375.0 mg | $67.50 | No | 5.6 | |
| Glutathione (Liposomal) | 130.0 mg | $51.95 | Yes | 5.1 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Your body's main antioxidant. Cells make it from cysteine, glycine, and glutamate. Direct oral supplementation has been controversial due to poor absorption.
Why people take it
Senaste liposomal forms and Setria® show meaningful blood-level increases. NAC + glycine remains cheaper and works upstream.
Our verdict
Take NAC + glycine (GlyNAC) unless you specifically want the direct form for a targeted use.
Structure & class
γ-Glutamyl-cysteinyl-glycine tripeptide.
Mechanism & clinical data
Richie 2015 showed 250 mg Setria® raised GSH stores. Liposomal forms improve on standard oral.
Pharmacokinetics
Rapid.
Dose & forms
What to watch out for
Non-liposomal oral GSH is largely broken down in digestion.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Glutathione, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Oral glutathione reliably raises body glutathione stores in humans, but the trial evidence for skin whitening and other marketed benefits is small and mixed.
Verified 2026-07-04. We update this section as new peer-reviewed trials land.
Best-supported claim
Oral glutathione raises measurable glutathione levels in blood, erythrocytes, plasma, and buccal cells. Richie et al.'s 2014 randomized, double-blinded, placebokontrollerad trial in 54 healthy non-smoking adults found 6 months of 1,000 mg/day increased erythrocyte and plasma glutathione by 30-35% and buccal cell glutathione by 260%, with levels returning to baseline after a 1-month washout (https://pubmed.ncbi.nlm.nih.gov/24791752/). In elderly type 2 diabetics, Kalamkar et al.'s 2022 trial in 250 diabetic patients found 500 mg/day for 6 months reduced oxidative DNA damage (8-OHdG) and, in the over-55 subgroup, significantly lowered HbA1c (https://pmc.ncbi.nlm.nih.gov/articles/PMC9137531/).
Not supported by the evidence base
Glutathione is marketed heavily as an oral or IV skin-whitening agent and a general anti-aging antioxidant, but the skin-lightening evidence is thin and inconsistent. A review of three RCTs found one trial showed significant melanin reduction only in sun-exposed areas, one found glutathione performed no better than placebo, and a third found benefits limited to subjects over 40 in specific skin areas, with color improvements disappearing within 6 months of stopping (https://pmc.ncbi.nlm.nih.gov/articles/PMC7196133/). Marketers also imply oral glutathione directly patches cellular antioxidant defenses body-wide, but raising blood glutathione does not equal proven clinical benefit for aging, energy, or immunity outside the diabetic HbA1c signal seen in one trial (https://pubmed.ncbi.nlm.nih.gov/24791752/).
Typical dose
250-1000 mg/day oral reduced glutathione, most study doses landing at 500 mg/day
Säkerhet
Oral glutathione at doses up to 1,000 mg/day for 6 months has shown no significant adverse events versus placebo in trials (https://pubmed.ncbi.nlm.nih.gov/24791752/). Intravenous and injectable glutathione, common in skin-whitening clinics, is not well studied for long-term safety and is not the form used in most oral-supplementation RCTs. Personer with asthma have reported bronchospasm after inhaled or nebulized glutathione, a different route not relevant to oral capsules. Pregnant or breastfeeding people and those with sulfa allergies should check with a physician before use, since glutathione synthesis depends on sulfur amino acid metabolism (https://pmc.ncbi.nlm.nih.gov/articles/PMC7196133/).
Interactions worth flagging
- maj theoretically alter chemotherapy drug efficacy by countering oxidative mechanisms some cancer therapies rely on
- No well-established prescription drug interactions documented in oral RCTs to date
Three recent studies to know
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Effects of GSH on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized Double-Blind Placebo-Controlled Crossover Clinical Trial
A 50 mg glutathione dose significantly lowered serum acetaldehyde levels versus placebo after alcohol consumption, but produced no significant improvement on subjective hangover symptom scores.
Läs studie → -
A Targeted Metabolomic Assessment of Oral Glutathione Supplementation
Targeted metabolomics found oral glutathione supplementation shifts sulfur amino acid and related metabolite pathways in supplemented adults.
Läs studie → -
Exploring the Säkerhet and Efficacy of Glutathione as a Skin-Lightening and Antioxidant Agent
Review of human trials concludes glutathione's skin-whitening effects are inconsistent, limited to some body areas or age groups, and not long-lasting after discontinuation.
Läs studie →
Landmark studies
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Richie et al. 2015
250 mg Setria®/dag raised body GSH stores over 6 months.
Läs studie →
Found in these produkter (4)
Alla produkter in our catalog that contain Glutathione, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Antioxidant →Molekyler in the same class, plus the actives most often formulated alongside Glutathione in our catalogue.
Frequently asked questions
What is Glutathione?
Your body's main antioxidant. Cells make it from cysteine, glycine, and glutamate. Direct oral supplementation has been controversial due to poor absorption.
What dose of Glutathione should I take?
The trial dose in published human studies is 500 mg per dag, with a range of 250 to 1000 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Glutathione safe?
Non-liposomal oral GSH is largely broken down in digestion.
What is the best Glutathione supplement?
We track 4 produkter containing Glutathione. The top-ranked product scores 6.4 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Glutathione?
Glutathione has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.