Grape seed extract · Grape seed extract (proanthocyanidins) — Vitis vinifera seed extract
A concentrated source of oligomeric proanthocyanidins (OPCs) from grape seeds that reduces postprandial oxidative stress and has shown benefits for menopausal symptoms and body composition.
Short answer
Grape seed extract (Grape seed extract (proanthocyanidins) — Vitis vinifera seed extract) is a antioxidant with evidence grade B, meaning it is supported by human RCTs. We track 0 produkter containing Grape seed extract. The top-ranked product scores 0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $0.00 per månad.
What it is
Grape seed extract is made from the seeds left over from winemaking, concentrated for their proanthocyanidin (a type of flavonoid) content — some of the most potent dietary antioxidants known.
Why people take it
Oxidative stress — damage from reactive molecules generated during normal metabolism — is one of several proposed contributors to cellular aging. Reducing oxidative load, particularly after meals when it spikes, is one plausible (though unproven) longevity-adjacent mechanism.
Our verdict
Solid short-term human data shows it reduces oxidative stress markers and, in one larger RCT, improved menopausal symptoms and body composition. However, there's no direct human longevity or hard-outcome data — the evidence supports biomarker changes, not lifespan or major disease reduction.
Structure & class
Standardized extracts are typically quantified by OPC content (percentage of oligomeric proanthocyanidins, often 90-95%).
Mechanism & clinical data
A controlled study (Sano et al., J Agric Food Chem 2002) gave 8 subjects a single 300 mg dose of GSE with a high-fat meal, showing significantly reduced postprandial oxidative stress markers compared to placebo. A larger RCT (Yang et al., Menopause 2014) randomized 96 menopausal women to 100 mg or 200 mg/day GSE for 8 weeks, finding improvements in menopausal symptom scores and body composition parameters versus placebo. A supporting review consolidates broader antioxidant and cardiovascular biomarker findings across GSE trials.
Pharmacokinetics
Proanthocyanidin oligomers have limited direct absorption; smaller monomeric/dimeric fractions and gut-microbiota metabolites (e.g., valerolactones) are the primär circulating bioactive forms, with effects typically assessed after weeks of continuous dosing.
Dose & forms
What to watch out for
High-dose supplementation may have mild anticoagulant-like effects; possible interaction with blood-thinning medications; quality/potency (OPC %) varies significantly across commercial produkter without third-party testing.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Grape seed extract, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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Sano A, et al. (2002). Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem. PMID 12475295.Sano A, et al. (2002). Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem. PMID 12475295.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Sano A, et al. (2002). Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem. PMID 12475295.
Sano A, et al. (2002). Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem. PMID 12475295.
Läs studie →
Found in these produkter
Alla produkter in our catalog that contain Grape seed extract, ranked by our overall score. Ranking is editorial, never paid.
No produkter in our catalog contain this yet.
Buying guides and comparisons
Related ingredients
Se alla in Antioxidant →Molekyler in the same class, plus the actives most often formulated alongside Grape seed extract in our catalogue.
Frequently asked questions
What is Grape seed extract?
Grape seed extract is made from the seeds left over from winemaking, concentrated for their proanthocyanidin (a type of flavonoid) content — some of the most potent dietary antioxidants known.
What dose of Grape seed extract should I take?
The trial dose in published human studies is 200 mg per dag, with a range of 100 to 300 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Grape seed extract safe?
High-dose supplementation may have mild anticoagulant-like effects; possible interaction with blood-thinning medications; quality/potency (OPC %) varies significantly across commercial produkter without third-party testing.
What is the best Grape seed extract supplement?
We track 0 produkter containing Grape seed extract. The top-ranked product scores 0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Grape seed extract?
Grape seed extract has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.