Hydroxytyrosol · 3,4-Dihydroxyphenylethanol (Hydroxytyrosol)
A potent olive polyphenol with strong in vitro antioxidant activity; human outcome data still limited.
Short answer
Hydroxytyrosol (3,4-Dihydroxyphenylethanol (Hydroxytyrosol)) is a longevity antioxidant with evidence grade C, meaning it is backed by mixed or small human trials. We track 2 produkter containing Hydroxytyrosol. Typical doses range from 20 to 30 mg per portion. The top-ranked product scores 5.9 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $189.00 per månad.
Top Hydroxytyrosol produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Youngr NMN | 20 mg | $88.00 | Yes | 5.9 | |
| Release | 30 mg | $189.00 | Yes | 4.9 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Hydroxytyrosol is the main antioxidant in olive oil. It is one of the most powerful free-radical scavengers known by ORAC value. European Food Säkerhet Authority approved a health claim for olive polyphenols protecting LDL cholesterol from oxidative damage at 5 mg/day.
Why people take it
In vitro and animal studies show anti-inflammatory, cardioprotective, and neuroprotective effects. Small human trials show improved lipid profiles and reduced oxidative stress markers. No large outcome trials on longevity endpoints yet.
Our verdict
Mechanistically credible and backed by EFSA for LDL protection. Dosing is uncertain; most supplements provide 5 to 30 mg/day, which is above the EFSA claim threshold.
Structure & class
3,4-Dihydroxyphenylethanol, a phenylethanoid. Derived from oleuropein hydrolysis in olive (Olea europaea) fruit and leaves. Direct radical scavenging via two catechol hydroxyl groups.
Mechanism & clinical data
EFSA Panel on Dietetic Produkter (2011) approved a health claim for olive polyphenols and LDL protection at 5 mg hydroxytyrosol/day. Multiple small RCTs (n=10 to 50) show reduced oxidized LDL, improved endothelial function, and lower inflammatory markers.
Pharmacokinetics
Rapid; plasma half-life under 1 hour. Metabolites detectable for several hours.
Dose & forms
What to watch out for
Many olive leaf supplements contain mostly oleuropein, not hydroxytyrosol itself. Check the label for hydroxytyrosol content specifically.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Hydroxytyrosol, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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Lopez-Huertas 2017 (Nutrition)RCT (n=30): hydroxytyrosol-enriched olive oil reduced oxidized LDL by 10 to 15% in healthy adults over 3 weeks.
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EFSA 2011EFSA approved health claim: olive polyphenols contribute to protection of blood lipids from oxidative stress at 5 mg hydroxytyrosol/day.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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EFSA 2011
EFSA approved health claim: olive polyphenols contribute to protection of blood lipids from oxidative stress at 5 mg hydroxytyrosol/day.
Läs studie → -
Lopez-Huertas 2017 (Nutrition)
RCT (n=30): hydroxytyrosol-enriched olive oil reduced oxidized LDL by 10 to 15% in healthy adults over 3 weeks.
Läs studie →
Found in these produkter (2)
Alla produkter in our catalog that contain Hydroxytyrosol, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Longevity antioxidant →Molekyler in the same class, plus the actives most often formulated alongside Hydroxytyrosol in our catalogue.
Frequently asked questions
What is Hydroxytyrosol?
Hydroxytyrosol is the main antioxidant in olive oil. It is one of the most powerful free-radical scavengers known by ORAC value. European Food Säkerhet Authority approved a health claim for olive polyphenols protecting LDL cholesterol from oxidative damage at 5 mg/day.
What dose of Hydroxytyrosol should I take?
The trial dose in published human studies is 10 mg per dag, with a range of 5 to 50 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Hydroxytyrosol safe?
Many olive leaf supplements contain mostly oleuropein, not hydroxytyrosol itself. Check the label for hydroxytyrosol content specifically.
What is the best Hydroxytyrosol supplement?
We track 2 produkter containing Hydroxytyrosol. The top-ranked product scores 5.9 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Hydroxytyrosol?
Hydroxytyrosol has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.