Luteolin · Luteolin
Flavonoid with strong anti-inflammatory and neuroprotective lab data. Human trials are essentially absent.
Short answer
Luteolin (Luteolin) is a polyphenol with evidence grade D, meaning it is primarily supported by animal studies. We track 1 produkter containing Luteolin. Typical doses range from 20 to 20 mg per portion. The top-ranked product scores 3.8 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $16.50 per månad.
Top Luteolin produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Bio-Luteolin | 20 mg | $16.50 | Yes | 3.8 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
A plant compound in celery, parsley, and chamomile. Popular in 'brain health' and mast-cell formulas.
Why people take it
In the lab, luteolin calms inflammatory signaling in brain immune cells (microglia) and inhibits mast-cell activation — hence its use in autism and 'histamine' protocols. But controlled human trials for these uses barely exist. What you are buying is a plausible mechanism.
Our verdict
Mechanistically interesting, clinically unproven. Any specific human claim goes beyond the data.
Structure & class
3',4',5,7-tetrahydroxyflavone. Microglial activation inhibitor and mast-cell stabilizer in vitro; low oral bioavailability (~10%).
Mechanism & clinical data
Reviews (2020) summarize neuroprotective, anti-inflammatory and anti-allergic effects across cell and animal models, with proposed benefits in neuroinflammation-driven conditions. Human evidence consists of small open-label series in autism spectrum contexts and one luteolin-containing formulation trial; no adequately powered RCT exists for any indication.
Pharmacokinetics
Short; conjugated rapidly in the gut and liver.
Dose & forms
What to watch out for
Bioavailability is the weak point — liposomal or complexed forms claim better uptake without published human comparisons. Enthusiastic autism-spectrum claims outrun the evidence.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Luteolin, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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Luteolin neuroprotection review 2020Review: luteolin shows consistent neuroprotective and anti-inflammatory effects in preclinical models; authors note the near-total absence of controlled human trials.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Luteolin neuroprotection review 2020
Review: luteolin shows consistent neuroprotective and anti-inflammatory effects in preclinical models; authors note the near-total absence of controlled human trials.
Läs studie →
Found in these produkter (1)
Alla produkter in our catalog that contain Luteolin, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Polyphenol →Molekyler in the same class, plus the actives most often formulated alongside Luteolin in our catalogue.
Frequently asked questions
What is Luteolin?
A plant compound in celery, parsley, and chamomile. Popular in 'brain health' and mast-cell formulas.
What dose of Luteolin should I take?
The trial dose in published human studies is 100 mg per dag, with a range of 50 to 200 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Luteolin safe?
Bioavailability is the weak point — liposomal or complexed forms claim better uptake without published human comparisons. Enthusiastic autism-spectrum claims outrun the evidence.
What is the best Luteolin supplement?
We track 1 produkter containing Luteolin. The top-ranked product scores 3.8 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Luteolin?
Luteolin has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.