Melaleuca · Melaleuca alternifolia (tea tree)
A botanical flagged by EU regulators for potential CMR properties in supplements.
Short answer
Melaleuca (Melaleuca alternifolia (tea tree)) is a botanical with evidence grade E, meaning it is only mechanistic evidence so far. We track 0 produkter containing Melaleuca. The top-ranked product scores 0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $0.00 per månad.
What it is
Melaleuca (tea tree) is primarily known for its essential oil used topically. It is sometimes included in supplements.
Why people take it
Ingestion of tea tree oil is toxic. EU regulators flagged Melaleuca for possible carcinogenic, mutagenic, or reprotoxic properties at supplement doses.
Our verdict
Not a longevity ingredient. Toxic when ingested. EU regulators have prioritized it for restriction.
Structure & class
Melaleuca alternifolia. Contains terpinen-4-ol. Essential oil is toxic if ingested.
Mechanism & clinical data
Oral toxicity documented. CMR concerns raised by HoA working group.
Pharmacokinetics
Not applicable for oral use.
Dose & forms
What to watch out for
Toxic if ingested. Topical use only.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Melaleuca, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU heads of food safety agencies prioritize Melaleuca for restrictionThe HoA Working Group on Food Supplements identified Melaleuca among 12 substances prioritized for Article 8 restriction. Flagged for possible carcinogenic, mutagenic, or reprotoxic properties. Tea tree oil is toxic if ingested.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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HoA 2024 (BVL/NVWA, EU)26-country EU working group prioritized Melaleuca for Article 8 restriction. Flagged for possible carcinogenic, mutagenic, or reprotoxic properties.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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HoA 2024 (BVL/NVWA, EU)
26-country EU working group prioritized Melaleuca for Article 8 restriction. Flagged for possible carcinogenic, mutagenic, or reprotoxic properties.
Läs studie →
Found in these produkter
Alla produkter in our catalog that contain Melaleuca, ranked by our overall score. Ranking is editorial, never paid.
No produkter in our catalog contain this yet.
Buying guides and comparisons
Related ingredients
Se alla in Botanical →Molekyler in the same class, plus the actives most often formulated alongside Melaleuca in our catalogue.
Frequently asked questions
What is Melaleuca?
Melaleuca (tea tree) is primarily known for its essential oil used topically. It is sometimes included in supplements.
What dose of Melaleuca should I take?
The trial dose in published human studies is 0 mg per dag, with a range of 0 to 0 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Melaleuca safe?
Toxic if ingested. Topical use only.
What is the best Melaleuca supplement?
We track 0 produkter containing Melaleuca. The top-ranked product scores 0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Melaleuca?
Melaleuca has evidence grade E, meaning it is only mechanistic evidence so far. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.