NAD+ · Nicotinamide Adenine Dinucleotide
The central cellular energy molecule that declines with age. Direct supplementation aims to bypass precursor conversion.
Short answer
NAD+ (Nicotinamide Adenine Dinucleotide) is a nad+ booster with evidence grade C, meaning it is backed by mixed or small human trials. We track 1 produkter containing NAD+. Typical doses range from 500 to 500 mg per portion. The top-ranked product scores 5.5 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $49.99 per månad.
Top NAD+ produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Unlimit Liposomal NAD+ | 500 mg | $49.99 | No | 5.5 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
NAD+ is a molecule every cell needs for energy production and DNA repair. Levels drop as you age. Some supplements contain NAD+ directly rather than precursors like NMN or NR.
Why people take it
Direct NAD+ supplementation, especially liposomal forms, aims to deliver the active molecule without needing conversion. Whether oral NAD+ survives digestion and reaches cells is debated.
Our verdict
Liposomal delivery may improve absorption compared to plain oral NAD+. Human clinical evidence for direct NAD+ supplementation is limited compared to NMN and NR precursors.
Structure & class
Nicotinamide Adenine Dinucleotide (NAD+). Oxidized form of the redox pair NAD+/NADH. Substrate for sirtuins, PARPs, and CD38.
Mechanism & clinical data
Liposomal formulations claim to protect NAD+ through the digestive tract. Limited human pharmacokinetic data. Precursor supplementation (NMN, NR) has stronger evidence for raising blood NAD+ levels.
Pharmacokinetics
Short intracellular half-life; NAD+ is continuously recycled via salvage pathway.
Dose & forms
What to watch out for
Oral NAD+ is largely degraded in the gut. Liposomal forms may improve bioavailability but human head-to-head data vs. precursors is lacking.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for NAD+, most recent first. Every entry links to its primär source.
-
EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
-
EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
-
EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
-
EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
Found in these produkter (1)
Alla produkter in our catalog that contain NAD+, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in NAD+ booster →Molekyler in the same class, plus the actives most often formulated alongside NAD+ in our catalogue.
Nothing else in the database sits close enough to this molecule to list.
Frequently asked questions
What is NAD+?
NAD+ is a molecule every cell needs for energy production and DNA repair. Levels drop as you age. Some supplements contain NAD+ directly rather than precursors like NMN or NR.
What dose of NAD+ should I take?
The trial dose in published human studies is 500 mg per dag, with a range of 250 to 1000 mg per dag. Always consult a qualified clinician before starting any supplement.
Is NAD+ safe?
Oral NAD+ is largely degraded in the gut. Liposomal forms may improve bioavailability but human head-to-head data vs. precursors is lacking.
What is the best NAD+ supplement?
We track 1 produkter containing NAD+. The top-ranked product scores 5.5 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for NAD+?
NAD+ has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.