Phosphatidylserine · Phosphatidylserine (PS)
Brain-cell membrane fat with qualified FDA health claim for cognitive decline. Modest but real human data.
Short answer
Phosphatidylserine (Phosphatidylserine (PS)) is a cognitive with evidence grade C, meaning it is backed by mixed or small human trials. We track 0 produkter containing Phosphatidylserine. The top-ranked product scores 0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $0.00 per månad.
What it is
A fat molecule that sits in the membranes of your brain cells and helps neurons signal. Levels decline with age.
Why people take it
Trials in older adults with memory complaints show modest improvements on memory tests at 100-300 mg/day. The evidence was strong enough that the US FDA allows a qualified health claim — with the caveat that the science is 'limited and preliminary'.
Our verdict
Modest, replicated effects on age-related memory complaints. Not a smart drug — a small nudge.
Structure & class
Phospholipid concentrated in neuronal membranes; supports receptor function and glucose metabolism in brain.
Mechanism & clinical data
Vakhapova et al. trials with PS plus omega-3 showed memory improvement in elderly with memory complaints. Kato-Kataoka et al. 2010 found soybean-derived PS improved memory scores in elderly Japanese subjects with mild cognitive impairment (RCT, 6 months). Modern supplements use soy or sunflower PS; the older, stronger trials used bovine-cortex PS, discontinued over BSE risk.
Pharmacokinetics
Incorporated into membranes over days; steady daily dosing used in trials.
Dose & forms
What to watch out for
Modern plant-derived PS is not chemically identical to the bovine PS from the strongest old trials. Many produkter dose at 100 mg — the low end.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Phosphatidylserine, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
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PS memory/attention RCTRandomized trial: phosphatidylserine supplementation improved memory and attention measures in older adults vs placebo.
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PS + omega-3 in elderly (Vakhapova)RCT in elderly with memory complaints: PS-DHA combination improved immediate recall vs placebo over 15 weeks.
Landmark studies
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PS memory/attention RCT
Randomized trial: phosphatidylserine supplementation improved memory and attention measures in older adults vs placebo.
Läs studie → -
PS + omega-3 in elderly (Vakhapova)
RCT in elderly with memory complaints: PS-DHA combination improved immediate recall vs placebo over 15 weeks.
Läs studie →
Found in these produkter
Alla produkter in our catalog that contain Phosphatidylserine, ranked by our overall score. Ranking is editorial, never paid.
No produkter in our catalog contain this yet.
Buying guides and comparisons
Related ingredients
Se alla in Cognitive →Molekyler in the same class, plus the actives most often formulated alongside Phosphatidylserine in our catalogue.
Frequently asked questions
What is Phosphatidylserine?
A fat molecule that sits in the membranes of your brain cells and helps neurons signal. Levels decline with age.
What dose of Phosphatidylserine should I take?
The trial dose in published human studies is 300 mg per dag, with a range of 100 to 300 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Phosphatidylserine safe?
Modern plant-derived PS is not chemically identical to the bovine PS from the strongest old trials. Many produkter dose at 100 mg — the low end.
What is the best Phosphatidylserine supplement?
We track 0 produkter containing Phosphatidylserine. The top-ranked product scores 0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Phosphatidylserine?
Phosphatidylserine has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.