Piperine · Piperine (alkaloid from Piper nigrum, black pepper)
The pungent alkaloid in black pepper, famous for dramatically increasing the bioavailability of curcumin and other poorly absorbed compounds when co-administered.
Short answer
Piperine (Piperine (alkaloid from Piper nigrum, black pepper)) is a bioavailability enhancer with evidence grade B, meaning it is supported by human RCTs. We track 0 produkter containing Piperine. The top-ranked product scores 0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $0.00 per månad.
What it is
Piperine is the compound responsible for black pepper's characteristic pungency, commercially extracted and standardized (often as Bioperine®) to be added to other supplements — most famously turmeric/curcumin produkter.
Why people take it
Piperine itself has minimal direct longevity relevance, but it matters enormously for the practical usefulness of other longevity supplements (like curcumin and resveratrol), which are otherwise very poorly absorbed when taken alone.
Our verdict
The landmark human trial showing a 2000% increase in curcumin bioavailability with piperine co-administration is one of the most robust and widely cited findings in the supplement world. Piperine's own direct health benefits are far less studied, but as a bioavailability enhancer it is well-established.
Structure & class
Piperine inhibits hepatic and intestinal glucuronidation and other Phase II metabolism enzymes, and may also inhibit P-glycoprotein efflux transporters, slowing the clearance of co-administered compounds.
Mechanism & clinical data
The foundational human trial (Shoba et al. 1998, Planta Medica) gave volunteers 20 mg piperine alongside 2 g curcumin as a single dose, finding a 2000% increase in curcumin bioavailability in humans (compared to 154% in rats), attributed to piperine's inhibition of curcumin glucuronidation. A review of piperine pharmacokinetics notes the compound itself has poor water solubility and low bioavailability, which is part of why it is typically co-formulated in enhanced-delivery matrices. Animal data (not yet replicated in humans) also suggests piperine can enhance resveratrol bioavailability by a similar mechanism.
Pharmacokinetics
Piperine itself has a relatively short plasma half-life (~1-2 hours) and low intrinsic oral bioavailability; its bioavailability-enhancing effect on co-administered compounds is the primär studied action rather than piperine's own systemic exposure.
Dose & forms
What to watch out for
By design, increases absorption/blood levels of many co-administered drugs and supplements, which can raise the risk of interactions or unexpectedly elevated drug levels (e.g., with certain prescription medications); can cause GI irritation at higher doses in sensitive individuals.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Piperine, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU heads of food safety agencies prioritize piperine for restrictionThe HoA Working Group on Food Supplements identified piperine among 12 substances prioritized for Article 8 restriction. Piperine was flagged for possible carcinogenic, mutagenic, or reprotoxic properties and was among 8 substances that triggered RASFF alerts between 2017 and mid-2022.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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HoA 2024 (BVL/NVWA, EU)26-country EU working group prioritized piperine for Article 8 restriction. Flagged for possible carcinogenic, mutagenic, or reprotoxic properties. Also identified in 8 substances that triggered RASFF alerts between 2017-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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Shoba G, et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. PMID 9619120.Shoba G, et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. PMID 9619120.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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HoA 2024 (BVL/NVWA, EU)
26-country EU working group prioritized piperine for Article 8 restriction. Flagged for possible carcinogenic, mutagenic, or reprotoxic properties. Also identified in 8 substances that triggered RASFF alerts between 2017-2022.
Läs studie → -
Shoba G, et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. PMID 9619120.
Shoba G, et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. PMID 9619120.
Läs studie →
Found in these produkter
Alla produkter in our catalog that contain Piperine, ranked by our overall score. Ranking is editorial, never paid.
No produkter in our catalog contain this yet.
Buying guides and comparisons
Related ingredients
Se alla in Bioavailability enhancer →Molekyler in the same class, plus the actives most often formulated alongside Piperine in our catalogue.
Nothing else in the database sits close enough to this molecule to list.
Frequently asked questions
What is Piperine?
Piperine is the compound responsible for black pepper's characteristic pungency, commercially extracted and standardized (often as Bioperine®) to be added to other supplements — most famously turmeric/curcumin produkter.
What dose of Piperine should I take?
The trial dose in published human studies is 20 mg per dag, with a range of 5 to 20 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Piperine safe?
By design, increases absorption/blood levels of many co-administered drugs and supplements, which can raise the risk of interactions or unexpectedly elevated drug levels (e.g., with certain prescription medications); can cause GI irritation at higher doses in sensitive individuals.
What is the best Piperine supplement?
We track 0 produkter containing Piperine. The top-ranked product scores 0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Piperine?
Piperine has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.