Piperine · Piperine (alkaloid från Piper nigrum, black pepper)
The pungent alkaloid i black pepper, famous for dramatically increasing the bioavailability of curcumin och other poorly absorbed compounds när co-administered.
Kort svar
Piperine (Piperine (alkaloid från Piper nigrum, black pepper)) is a bioavailability enhancer med evidensnivå B, vilket betyder att det stöds av humana RCT. Vi spårar 1 produkter som innehåller Piperine. Typiska doser sträcker sig från 5 till 5 mg per portion. Den topprankade produktenen får 4.8 av 10 på vår sammansatta skala (dos, evidens, pris, testning, transparens). Priser sträcker sig upp till $54.87 per månad.
Top Piperine produkter
| Produkt | Varumärke | Dos | Pris/mo | 3rd-party testad | Poäng |
|---|---|---|---|---|---|
| Berberin 500mg with Ceylon Cinnamon | 5 mg | $54.87 | Yes | 4.8 |
Betygen är redaktionella bedömningar, inte en vetenskaplig standard. Se how we poäng.
What it is
Piperine is the compound responsible for black pepper's characteristic pungency, commercially extracted och standardized (often as Bioperine®) till be added till other tillskott — most famously turmeric/curcumin produkter.
Why personer take it
Piperine itself has minimal direct longevity relevance, but it matters enormously for the practical usefulness of other longevity tillskott (like curcumin och resveratrol), which are otherwise very poorly absorbed när taken alone.
Our verdict
The landmark human prövning showing a 2000% increase i curcumin bioavailability with piperine co-administration is one of the most robust och widely cited findings i the supplement world. Piperine's own direct health benefits are far less studied, but as a bioavailability enhancer it is well-established.
Structure & class
Piperine inhibits hepatic och intestinal glucuronidation och other Phase II metabolism enzymes, och may also inhibit P-glycoprotein efflux transporters, slowing the clearance of co-administered compounds.
Mekanism & clinical data
The foundational human prövning (Shoba et al. 1998, Planta Medica) gave volunteers 20 mg piperine alongside 2 g curcumin as a single dos, finding a 2000% increase i curcumin bioavailability i humans (compared till 154% i rats), attributed till piperine's inhibition of curcumin glucuronidation. A review of piperine farmakokinetik notes the compound itself has poor water solubility och low bioavailability, which is part of why it is typically co-formulated i enhanced-delivery matrices. Djurdata (not yet replicated i humans) also suggests piperine can enhance resveratrol bioavailability by a similar mekanism.
Farmakokinetik
Piperine itself has a relatively short plasma half-life (~1-2 hours) och low intrinsic oral bioavailability; its bioavailability-enhancing effect on co-administered compounds is the primär studied action rather than piperine's own systemic exposure.
Dos & forms
What till watch out for
By design, increases absorption/blood levels of many co-administered drugs och tillskott, which can raise the risk of interaktioner or unexpectedly elevated drug levels (e.g., with certain prescription medications); can cause GI irritation at higher doser i sensitive individuals.
Where this dos kommer från
The trial dos above is our redaktionellt val från the publicerade humana studier för denna ingrediens. We choose the dos that the best-available studier used on the endpoint most relevant till longevity. The range shows the lowest och highest doser testad i published trials. The landmark studier below are the papers we read till set it. You can click through och check our work.
When new trials publish, our automated sweeps flag them. If a new studie materially changes the dos, we update it genom redaktionell granskning och registrerar den gamla dos, new dos, och the triggering studie i varje affected produkt's rekommendation history. The dos is never changed automatiskt.
Regelverk status
Timeline
Regelverk events, evidensnivå changes, och key research milestones for Piperine, most recent first. Varje entry links till its primär source.
-
EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling i april 2025 further tightened the requirements for how botanical ingredienser (herbs, plant extracts) can be marketed with health claims i the EU, effectively removing much of the flexibility of the on-hold list.
-
EU heads of food säkerhet agencies prioritize piperine for restrictionThe HoA Working Group on Food Tillskott identified piperine among 12 substances prioritized for Artikel 8 restriction. Piperine was flagged for possible carcinogenic, mutagenic, or reprotoxic properties och was among 8 substances that triggered RASFF alerts between 2017 och mid-2022.
-
EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Tillskott (26 European countries) published its first report evaluating 117 substances used i food tillskott. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, och 12 were prioritized for Artikel 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, och L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 och mid-2022.
-
HoA 2024 (BVL/NVWA, EU)26-country EU working group prioritized piperine for Artikel 8 restriction. Flagged for possible carcinogenic, mutagenic, or reprotoxic properties. Also identified i 8 substances that triggered RASFF alerts between 2017-2022.
-
EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition och health claims made on foods, including tillskott. Only claims listed i the EU Register of authorised claims can be used. Rejected botanical claims are held i a separate on-hold list.
-
Shoba G, et al. (1998). Influence of piperine on the farmakokinetik of curcumin i animals och human volunteers. Planta Med. PMID 9619120.Shoba G, et al. (1998). Influence of piperine on the farmakokinetik of curcumin i animals och human volunteers. Planta Med. PMID 9619120.
-
EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingrediens without a history of consumption i the EU before 15 maj 1997 till be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingrediens, urolithin A, och many other longevity actives.
Landmark studier
-
HoA 2024 (BVL/NVWA, EU)
26-country EU working group prioritized piperine for Artikel 8 restriction. Flagged for possible carcinogenic, mutagenic, or reprotoxic properties. Also identified i 8 substances that triggered RASFF alerts between 2017-2022.
Läs studie → -
Shoba G, et al. (1998). Influence of piperine on the farmakokinetik of curcumin i animals och human volunteers. Planta Med. PMID 9619120.
Shoba G, et al. (1998). Influence of piperine on the farmakokinetik of curcumin i animals och human volunteers. Planta Med. PMID 9619120.
Läs studie →
Found i these produkter (1)
Alla produkter i vår katalog that contain Piperine, rankade efter vårt helhetsbetyg. Rankningen är redaktionell, aldrig betald.
Buying guides och comparisons
Related ingredienser
Se alla i Bioavailability enhancer →Molekyler i the same class, plus the actives most often formulated alongside Piperine i our catalogue.
Frequently asked questions
What is Piperine?
Piperine is the compound responsible for black pepper's characteristic pungency, commercially extracted och standardized (often as Bioperine®) till be added till other tillskott — most famously turmeric/curcumin produkter.
What dos of Piperine should I take?
The trial dos i published human studier is 20 mg per dag, with a range of 5 till 20 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Piperine safe?
By design, increases absorption/blood levels of many co-administered drugs och tillskott, which can raise the risk of interaktioner or unexpectedly elevated drug levels (e.g., with certain prescription medications); can cause GI irritation at higher doser i sensitive individuals.
What is the best Piperine supplement?
Vi spårar 1 produkter som innehåller Piperine. Den topprankade produktenen får 4.8 av 10 på vår sammansatta skala, which evaluates dos, evidens, pris, tredjepartstestning, och transparens. See jämförelsetabellen ovan. Betygen är redaktionella bedömningar, inte en vetenskaplig standard.
What is the evidensnivå for Piperine?
Piperine has evidensnivå B, vilket betyder att det stöds av humana RCT. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarkörresultat. Grade C means mixed or small human trials. See our evidens grading metodik.
Data verification
Evidens grades are reviewed när new human RCTs are published. Produkt counts update automatiskt as new produkter are added. Dos ranges reflect published trial data, not varumärke recommendations. Read how we verify.