Quercetin Phytosome · Quercetin complexed with sunflower phospholipids (lecithin delivery system)
A lecithin-bound quercetin form built to fix quercetin's biggest problem: almost none of a standard dose reaches the blood.
Short answer
Quercetin Phytosome (Quercetin complexed with sunflower phospholipids (lecithin delivery system)) is a polyphenol / senolytic-adjacent with evidence grade B, meaning it is supported by human RCTs. We track 1 produkter containing Quercetin Phytosome. Typical doses range from 25.0 to 25.0 mg per portion. The top-ranked product scores 5.5 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $19.89 per månad.
Top Quercetin Phytosome produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Senolytic Activator | 25.0 mg | $19.89 | Yes | 5.5 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Regular quercetin dissolves poorly and most of a dose never gets absorbed. This version wraps quercetin in a phospholipid shell, the same kind of fat molecule that makes up cell membranes, so more of it survives digestion and enters circulation.
Why people take it
A human crossover trial found the phytosome form reached plasma levels up to 20 times higher than the same dose of plain quercetin, with no notable side effects. Quercetin itself is one of the two compounds in the original Mayo Clinic senolytic combination (with dasatinib), so a better-absorbed form matters for anyone using it for that purpose.
Our verdict
If you are taking quercetin specifically for absorption-dependent effects, the phytosome form has real human pharmacokinetic data behind it. Regular quercetin is fine for general polyphenol intake at a lower cost.
Structure & class
Quercetin aglycone complexed 1:1 by weight with food-grade sunflower lecithin (phosphatidylcholine), commercialised as Quercetin Phytosome / Quercefit (Indena). Standardised to roughly 40% quercetin by weight.
Mechanism & clinical data
Riva et al. 2018 (crossover PK study, n=12) measured a Cmax about 20-fold and an AUC about 18-fold higher for Quercetin Phytosome versus unformulated quercetin at matched doses. The mechanism is improved GI solubility and enterocyte membrane permeability from the phospholipid carrier, not a change to quercetin itself.
Pharmacokinetics
Not separately characterised from quercetin; absorption profile studied over 24 hours in the pharmacokinetic trial.
Dose & forms
What to watch out for
The 20-fold bioavailability data is specific to the branded phytosome form studied by Riva et al.; it should not be assumed for other enhanced quercetin blends without their own pharmacokinetic data. No head-to-head trial yet compares clinical outcomes (not just blood levels) between phytosome and standard quercetin.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Quercetin Phytosome, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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Riva et al. 2018Quercetin Phytosome reached plasma quercetin levels up to 20-fold higher than unformulated quercetin at matched doses in a human crossover trial.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Riva et al. 2018
Quercetin Phytosome reached plasma quercetin levels up to 20-fold higher than unformulated quercetin at matched doses in a human crossover trial.
Läs studie →
Found in these produkter (1)
Alla produkter in our catalog that contain Quercetin Phytosome, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Polyphenol / Senolytic-adjacent →Molekyler in the same class, plus the actives most often formulated alongside Quercetin Phytosome in our catalogue.
Frequently asked questions
What is Quercetin Phytosome?
Regular quercetin dissolves poorly and most of a dose never gets absorbed. This version wraps quercetin in a phospholipid shell, the same kind of fat molecule that makes up cell membranes, so more of it survives digestion and enters circulation.
What dose of Quercetin Phytosome should I take?
The trial dose in published human studies is 250 mg per dag, with a range of 250 to 500 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Quercetin Phytosome safe?
The 20-fold bioavailability data is specific to the branded phytosome form studied by Riva et al.; it should not be assumed for other enhanced quercetin blends without their own pharmacokinetic data. No head-to-head trial yet compares clinical outcomes (not just blood levels) between phytosome and standard quercetin.
What is the best Quercetin Phytosome supplement?
We track 1 produkter containing Quercetin Phytosome. The top-ranked product scores 5.5 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Quercetin Phytosome?
Quercetin Phytosome has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.