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Foundational

Riboflavin (B2) · Riboflavin

Cheap B-vitamin; migraine prevention at 400 mg/day.

B
Bevisning grade
Human RCTs, biomarker outcomes

Short answer

Riboflavin (B2) (Riboflavin) is a foundational with evidence grade B, meaning it is supported by human RCTs. We track 3 produkter containing Riboflavin (B2). Typical doses range from 1.3 to 3.0 mg per portion. The top-ranked product scores 5.8 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $34.99 per månad.

Bevisning grade: B Produkter in database: 3 Kategori: Foundational

Top Riboflavin (B2) produkter

ProductVarumärkeDosePris/mo3rd-party testedPoäng
Vital Proteins Beauty Boost Capsules3.0 mg$30.00No5.8
Seed AM-02 Energy + Focus1.3 mg$34.99Yes5.4
Seed PM-02 Sleep + Restore1.3 mg$34.99Yes5.4

Scores are editorial judgments, not a scientific standard. Se how we score.

What it is

A B-vitamin your mitochondria need. High-dose (400 mg/day) has been shown to prevent migraines.

Why people take it

Schoenen 1998 showed migraine prevention. Otherwise obscure.

Our verdict

Cheap and specific, worth trying for chronic migraine sufferers.

Structure & class

Riboflavin; cofactor for FAD/FMN.

Mechanism & clinical data

Schoenen 1998 established migraine prevention at 400 mg/day.

Pharmacokinetics

~1 hour.

Dose & forms

Trial dose
400 mg
/ day
Range in trials
100 to 400 mg
/ day
Common forms
Capsule/tablet

What to watch out for

Turns urine bright yellow (harmless).

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regelverk status

EUFood supplement
USDietary supplement
UKFood supplement
CANHP

Timeline

Regelverk events, evidence grade changes, and key research milestones for Riboflavin (B2), most recent first. Every entry links to its primär source.

  • 2025-04 Regelverk single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regelverk confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
  • 2006-12 Regelverk confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
  • 1998 Research milestone
    Schoenen 1998
    400 mg/day riboflavin reduced migraine frequency.
  • 1997 Regelverk confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.

Landmark studies

  • Schoenen 1998

    400 mg/day riboflavin reduced migraine frequency.

    Läs studie →

Found in these produkter (3)

Alla produkter in our catalog that contain Riboflavin (B2), ranked by our overall score. Ranking is editorial, never paid.

Redaktionellt guides

Buying guides and comparisons

Neighbouring molecules

Related ingredients

Se alla in Foundational →

Molekyler in the same class, plus the actives most often formulated alongside Riboflavin (B2) in our catalogue.

Omega-3 (EPA/DHA)Asame categoryVitamin D3Asame categoryVitamin K2Bsame categoryMagnesiumAsame categoryVitamin B12Asame categoryFolate (5-MTHF)Bsame categoryZincAsame categorySeleniumAsame category

Frequently asked questions

What is Riboflavin (B2)?

A B-vitamin your mitochondria need. High-dose (400 mg/day) has been shown to prevent migraines.

What dose of Riboflavin (B2) should I take?

The trial dose in published human studies is 400 mg per dag, with a range of 100 to 400 mg per dag. Always consult a qualified clinician before starting any supplement.

Is Riboflavin (B2) safe?

Turns urine bright yellow (harmless).

What is the best Riboflavin (B2) supplement?

We track 3 produkter containing Riboflavin (B2). The top-ranked product scores 5.8 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Riboflavin (B2)?

Riboflavin (B2) has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Bevisning grade
B
Human RCTs, biomarker outcomes
Research dose
400 mg
Verified n/a
Produkter tracked
3
Uppdaterad continuously
Säkerhet signal
Turns urine bright yellow (harmless).
Verified n/a

Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.