Salicin · Salicin (Willow Bark Extract)
A willow bark compound with mild mTOR-modulating and anti-inflammatory activity; sometimes called a natural rapamycin analog.
Short answer
Salicin (Salicin (Willow Bark Extract)) is a natural rapalog / anti-inflammatory with evidence grade D, meaning it is primarily supported by animal studies. We track 1 produkter containing Salicin. Typical doses range from 100 to 100 mg per portion. The top-ranked product scores 4.2 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $49.00 per månad.
Top Salicin produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Natural Rapalogs | 100 mg | $49.00 | No | 4.2 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Salicin is the active compound in willow bark, the natural precursor to aspirin. Some researchers classify it as a natural rapalog because it appears to modulate mTOR signaling, the same pathway targeted by rapamycin.
Why people take it
Willow bark has been used for anti-inflammatory purposes for centuries. The mTOR connection is primarily mechanistic and animal-based. No human trials on longevity endpoints exist.
Our verdict
Interesting as a mild natural mTOR modulator, but the evidence is far weaker than for rapamycin. Low risk at typical doses. Long-term safety data is limited.
Structure & class
2-(Hydroxymethyl)phenyl-beta-D-glucopyranoside. A phenolic glycoside from Salix species. Metabolized in vivo to salicylic acid. Also shows partial mTORC1 inhibition in cell studies.
Mechanism & clinical data
In vitro studies show salicin and its derivatives inhibit mTORC1 signaling, though weakly compared to rapamycin. Human data is limited to anti-inflammatory analgesic studies. No longevity outcome data.
Pharmacokinetics
Salicylic acid half-life 2 to 4 hours; parent compound metabolized rapidly.
Dose & forms
What to watch out for
Do not combine with NSAIDs or blood thinners. Some people are allergic to salicylates. Quality varies between willow bark extract suppliers.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Salicin, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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Vlachojannis 2009 (Phytotherapy Research)Systematic review: willow bark extract equivalent to 120 to 240 mg salicin showed modest analgesic efficacy in low-back pain RCTs.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Vlachojannis 2009 (Phytotherapy Research)
Systematic review: willow bark extract equivalent to 120 to 240 mg salicin showed modest analgesic efficacy in low-back pain RCTs.
Läs studie →
Found in these produkter (1)
Alla produkter in our catalog that contain Salicin, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Natural rapalog / Anti-inflammatory →Molekyler in the same class, plus the actives most often formulated alongside Salicin in our catalogue.
Frequently asked questions
What is Salicin?
Salicin is the active compound in willow bark, the natural precursor to aspirin. Some researchers classify it as a natural rapalog because it appears to modulate mTOR signaling, the same pathway targeted by rapamycin.
What dose of Salicin should I take?
The trial dose in published human studies is 100 mg per dag, with a range of 60 to 240 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Salicin safe?
Do not combine with NSAIDs or blood thinners. Some people are allergic to salicylates. Quality varies between willow bark extract suppliers.
What is the best Salicin supplement?
We track 1 produkter containing Salicin. The top-ranked product scores 4.2 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Salicin?
Salicin has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.