SIRT6 Activator · Fucoidan (SIRT6-activating)
DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.
Short answer
SIRT6 Activator (Fucoidan (SIRT6-activating)) is a sirtuin / longevity with evidence grade E, meaning it is only mechanistic evidence so far. We track 2 produkter containing SIRT6 Activator. Typical doses range from 400.0 to 1600.0 mg per portion. The top-ranked product scores 6.4 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $203.00 per månad.
Top SIRT6 Activator produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| DoNotAge® routine (15-in-1 Daily Sachet) | 1600.0 mg | $203.00 | Yes | 6.4 | |
| SIRT6Activator® | 400.0 mg | $97.00 | Yes | 3.5 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
SIRT6 is a longevity gene. Mice overexpressing it live ~30% longer. A specific type of seaweed extract (fucoidan) activates SIRT6 in the lab. DoNotAge markets it as 'SIRT6 Activator'.
Why people take it
Mechanism looks real: fucoidan increases SIRT6 activity in cell studies. Human trials on longevity endpoints don't exist yet. Rodent lifespan data is preliminary.
Our verdict
Interesting mechanism, no meaningful human evidence yet. Priced like a proven longevity drug. Wait for actual data unless you're happy to fund early-stage research.
Structure & class
Sulfated polysaccharide from Fucus vesiculosus/Ecklonia cava. Reported allosteric SIRT6 activator.
Mechanism & clinical data
Rezaei-Sadabady et al. and DoNotAge's in-house data show SIRT6 activation and mouse healthspan signals. No human RCTs. Estimated human-equivalent dose from mouse studies is ~4 g/day, far above marketed doses.
Pharmacokinetics
Uncertain in humans.
Dose & forms
What to watch out for
Fucoidan is inexpensive as a seaweed extract. High-priced 'SIRT6 activator' branding doesn't mean higher potency, check fucoidan mg/capsule.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for SIRT6 Activator, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
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Rahman et al. 2014
Preclinical evidence for SIRT6-dependent metabolic effects of fucoidan.
Läs studie →
Found in these produkter (2)
Alla produkter in our catalog that contain SIRT6 Activator, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Sirtuin / Longevity →Molekyler in the same class, plus the actives most often formulated alongside SIRT6 Activator in our catalogue.
Frequently asked questions
What is SIRT6 Activator?
SIRT6 is a longevity gene. Mice overexpressing it live ~30% longer. A specific type of seaweed extract (fucoidan) activates SIRT6 in the lab. DoNotAge markets it as 'SIRT6 Activator'.
What dose of SIRT6 Activator should I take?
The trial dose in published human studies is 4000 mg per dag, with a range of 1000 to 4000 mg per dag. Always consult a qualified clinician before starting any supplement.
Is SIRT6 Activator safe?
Fucoidan is inexpensive as a seaweed extract. High-priced 'SIRT6 activator' branding doesn't mean higher potency, check fucoidan mg/capsule.
What is the best SIRT6 Activator supplement?
We track 2 produkter containing SIRT6 Activator. The top-ranked product scores 6.4 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for SIRT6 Activator?
SIRT6 Activator has evidence grade E, meaning it is only mechanistic evidence so far. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.