Betaine (TMG) · Betaine Anhydrous (Trimethylglycine)
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
Short answer
Betaine (TMG) (Betaine Anhydrous (Trimethylglycine)) is a methylation support with evidence grade C, meaning it is backed by mixed or small human trials. We track 15 produkter containing Betaine (TMG). Typical doses range from 25 to 2000 mg per portion. The top-ranked product scores 7.0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $203.00 per månad.
Top Betaine (TMG) produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| NiaCel 400 | 25 mg | $65.00 | Yes | 7.0 | |
| Nicotinamide Riboside Pro 300 + 100mg TMG | 100.0 mg | $24.95 | Yes | 6.9 | |
| ResveraCel | 150 mg | $105.00 | Yes | 6.6 | |
| Pure TMG | 2000 mg | $30.00 | Yes | 6.5 | |
| DoNotAge® routine (15-in-1 Daily Sachet) | 1000.0 mg | $203.00 | Yes | 6.4 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Betaine (also called trimethylglycine, or TMG) is a small molecule found naturally in beets and other foods. It donates a methyl group to help convert homocysteine back into methionine.
Why people take it
At gram-level doses (1.5-6 g/day) betaine has decent human evidence for lowering homocysteine and some liver-fat markers. The 25-150 mg doses typically added to NAD+ combination produkter are far below those studied amounts and mainly function as a formulation cofactor rather than a dosed active ingredient.
Our verdict
Real ingredient with real evidence, but only at doses much higher than what's typically included in NAD+ combination capsules. Treat small doses in blends as a minor add-on, not a therapeutic dose.
Structure & class
Trimethylglycine (TMG); methyl donor in the betaine-homocysteine methyltransferase (BHMT) pathway.
Mechanism & clinical data
Clinical trials on homocysteine reduction and non-alcoholic fatty liver disease use 1.5-6 g/day; doses under 200 mg/day have little independent human outcome data.
Pharmacokinetics
Hours; renally cleared.
Dose & forms
What to watch out for
Doses under roughly 500 mg/day (as seen in most NAD+ combination produkter) are well below the gram-level doses used in the supporting human trials.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Betaine (TMG), most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
Found in these produkter (15)
Alla produkter in our catalog that contain Betaine (TMG), ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Methylation support →Molekyler in the same class, plus the actives most often formulated alongside Betaine (TMG) in our catalogue.
Frequently asked questions
What is Betaine (TMG)?
Betaine (also called trimethylglycine, or TMG) is a small molecule found naturally in beets and other foods. It donates a methyl group to help convert homocysteine back into methionine.
What dose of Betaine (TMG) should I take?
The trial dose in published human studies is 3000 mg per dag, with a range of 1500 to 6000 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Betaine (TMG) safe?
Doses under roughly 500 mg/day (as seen in most NAD+ combination produkter) are well below the gram-level doses used in the supporting human trials.
What is the best Betaine (TMG) supplement?
We track 15 produkter containing Betaine (TMG). The top-ranked product scores 7.0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Betaine (TMG)?
Betaine (TMG) has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.