Ubiquinol · Ubiquinol (reduced CoQ10)
The active, reduced form of CoQ10 with better absorption. Same trials, same evidence — at a higher price.
Short answer
Ubiquinol (Ubiquinol (reduced CoQ10)) is a mitochondrial with evidence grade B, meaning it is supported by human RCTs. We track 0 produkter containing Ubiquinol. The top-ranked product scores 0 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $0.00 per månad.
What it is
CoQ10 exists in two forms: ubiquinone (oxidized) and ubiquinol (reduced, active). Your body converts one to the other. Ubiquinol supplements skip the conversion step.
Why people take it
Pharmacokinetic studies show ubiquinol raises blood CoQ10 levels more per milligram than standard ubiquinone — roughly 1.5 to 2x. Whether that matters clinically is less clear, because the big CoQ10 outcome trials (heart failure, statin muscle symptoms) used plain ubiquinone.
Our verdict
Better absorbed, same underlying evidence as CoQ10. Worth the premium mainly for older adults or people with absorption issues.
Structure & class
Reduced CoQ10, electron carrier in mitochondrial complex I-III and lipid-phase antioxidant.
Mechanism & clinical data
Bioavailability studies show ubiquinol produces higher and more sustained plasma CoQ10 than ubiquinone at equal doses. Outcome evidence inherits from the CoQ10 literature: Q-SYMBIO trial (Mortensen 2014) found 300 mg/day CoQ10 reduced major cardiac events in chronic heart failure (n=420, 2 years). Age-related decline in endogenous synthesis supports supplementation rationale in older adults.
Pharmacokinetics
Plasma half-life ~33 hours; takes 2+ weeks to reach steady state.
Dose & forms
What to watch out for
Costs roughly 2x ubiquinone. Both forms are fat-soluble — take with a meal containing fat or absorption drops sharply. Can reduce the effect of warfarin.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Ubiquinol, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
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Langsjoen et al. (advanced heart failure)Open-label study in advanced heart failure patients: ubiquinol improved ejection fraction and functional class when standard ubiquinone had plateaued.
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CoQ10 bioavailability study (PMC)Comparative pharmacokinetics: ubiquinol formulation delivered significantly higher plasma CoQ10 exposure than standard ubiquinone at equal dose.
Landmark studies
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Langsjoen et al. (advanced heart failure)
Open-label study in advanced heart failure patients: ubiquinol improved ejection fraction and functional class when standard ubiquinone had plateaued.
Läs studie → -
CoQ10 bioavailability study (PMC)
Comparative pharmacokinetics: ubiquinol formulation delivered significantly higher plasma CoQ10 exposure than standard ubiquinone at equal dose.
Läs studie →
Found in these produkter
Alla produkter in our catalog that contain Ubiquinol, ranked by our overall score. Ranking is editorial, never paid.
No produkter in our catalog contain this yet.
Buying guides and comparisons
Related ingredients
Se alla in Mitochondrial →Molekyler in the same class, plus the actives most often formulated alongside Ubiquinol in our catalogue.
Frequently asked questions
What is Ubiquinol?
CoQ10 exists in two forms: ubiquinone (oxidized) and ubiquinol (reduced, active). Your body converts one to the other. Ubiquinol supplements skip the conversion step.
What dose of Ubiquinol should I take?
The trial dose in published human studies is 200 mg per dag, with a range of 100 to 300 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Ubiquinol safe?
Costs roughly 2x ubiquinone. Both forms are fat-soluble — take with a meal containing fat or absorption drops sharply. Can reduce the effect of warfarin.
What is the best Ubiquinol supplement?
We track 0 produkter containing Ubiquinol. The top-ranked product scores 0 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Ubiquinol?
Ubiquinol has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.