Urolitin A · Urolitin A
The only longevity ingredient with a replicated RCT showing muscle-strength gains.
Short answer
Urolitin A (Urolitin A) is a mitochondrial with evidence grade A, meaning it is well-supported by replicated human trials. We track 9 produkter containing Urolitin A. Typical doses range from 300 to 1000 mg per portion. The top-ranked product scores 8.6 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $130.00 per månad.
Top Urolitin A produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Mitopure® Powder | 1000 mg | $130.00 | Yes | 8.6 | |
| Urolithin-A Liposomal 1,000mg | 1000 mg | $59.00 | Yes | 8.5 | |
| Mitopure® Softgel | 500 mg | $65.00 | Yes | 7.5 | |
| Full Spectrum Urolitin A - 60 capsules | 500.0 mg | $55.97 | Yes | 7.5 | |
| Timeline Mitopure Gummies (Urolitin A, Strawberry) | 500.0 mg | $125.00 | Yes | 7.0 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
A molecule your gut bacteria make from pomegranate and berries, if you have the right bacteria. Only about 40% of people do. Urolitin A tells old, damaged mitochondria (the power plants inside cells) to recycle themselves, so cells work better.
Why people take it
The NCT03464500 trial in older adults showed 12% more muscle strength after 4 months on 1000 mg/day, and that finding was later replicated. That kind of hard endpoint result is very rare in the longevity space.
Our verdict
The strongest evidence in the field right now. Missing from most 'longevity stacks' because it's expensive and patented, Timeline Mitopure® is the only serious supplier of the licensed compound.
Structure & class
6H-dibenzo[b,d]pyran-6-one derivative produced by gut microbiota from ellagitannins in pomegranate/walnuts/berries.
Mechanism & clinical data
NCT03464500 (Andreux et al. 2019 Nature Metabolism; Singh et al. 2022 Cell Reports Medicine) demonstrated Urolitin A induces mitophagy in humans and improved muscular endurance/strength in older adults at 500 and 1000 mg. Replicated in NCT04160312.
Pharmacokinetics
8 to 17 hours (systemic exposure after single dose).
Dose & forms
What to watch out for
Cheap 'urolithin A precursor' produkter (pomegranate extract) don't work if you lack the right gut bacteria. Only direct Urolitin A supplements are reliable.
Säkerhet limits and interactions
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
Source: https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Urolithin_A_UPDATE_(supplement).pdf
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Urolitin A, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EFSA opinion clears urolithin A as a novel foodThe European Food Säkerhet Authority issued a positive scientific opinion on urolithin A (as sold by Amazentis / Timeline) as a novel food ingredient, subject to specified conditions of use. This is what allowed Mitopure to be sold in the EU.
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Singh et al. 2022 (Cell Reports Medicine)4 months at 1000 mg/day improved leg muscle strength ~12% in adults 40 to 65.
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EFSA opinion clears urolithin A as a novel foodEFSA published a positive safety opinion on urolithin A as a novel food, supporting its authorization for use in food supplements. The opinion assessed safety, bioavailability, and manufacturing specifications.
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Andreux et al. 2019 (Nature Metabolism)First-in-human study confirmed mitophagy induction and safety at 500 and 1000 mg.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Reported adverse events
Consumer reports submitted to an official government adverse-event database. These reports mention this ingredient but do not prove it caused the reaction. Report volume reflects market penetration as much as inherent risk.
Retrieved from the FDA Adverse Event Reporting System (CAERS) via the openFDA API. Verified 2026-08-06. Reports are voluntary consumer submissions and mandatory serious-event filings. They establish surveillance, not causality.
Urolitin A is a gut-bacteria metabolite of pomegranate ellagitannins that activates mitophagy and modestly boosts muscle strength.
Verified 2026-08-06. We update this section as new peer-reviewed trials land.
Best-supported claim
Anurag Singh, Davide D'Amico, and colleagues at Amazentis ran the ATLAS trial, a randomized, placebokontrollerad study in 88 overweight, low-endurance middle-aged adults given 500 mg or 1000 mg of urolithin A (Mitopure) daily for 4 months (https://pmc.ncbi.nlm.nih.gov/articles/PMC9133463/). Leg muscle strength rose about 10 to 12% at both doses versus placebo, plasma acylcarnitines and C-reactive protein fell, and skeletal muscle biopsies showed increased mitophagy-related protein expression. A 2024 systematisk översikt by researchers pooling five studies and 250 participants confirmed urolithin A consistently increases muscle strength and endurance and lowers inflammation, but found no effect on maximal ATP production, mitochondrial biogenesis, body composition, or physical function tests (https://pubmed.ncbi.nlm.nih.gov/39002645/).
Not supported by the evidence base
Urolitin A is marketed as a comprehensive anti-aging compound for brain, skin, muscle, and cellular energy. Human RCT evidence supports only a narrow slice of this: modest muscle strength and endurance gains, plus some anti-inflammatory markers. The 2024 systematisk översikt explicitly found no effect on mitochondrial ATP production, biogenesis, or overall physical function tests, despite marketing language about 'boosting mitochondrial health' (https://pubmed.ncbi.nlm.nih.gov/39002645/). A 2026 review states plainly that no completed human trial has evaluated cognitive or neurodegenerative disease outcomes, so brain-health claims rest on mouse data alone (https://pubmed.ncbi.nlm.nih.gov/42468665/). The JAMA Network Open trial in older adults also missed its primär endpoints, hand-grip ATP production and 6-minute walk distance, with only secondary endurance measures reaching significance (https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244).
Typical dose
500 mg to 1000 mg once daily (Mitopure formulation used in nearly all published trials)
Säkerhet
Urolitin A has been safe and well tolerated across every published trial to date, including 4-month dosing at 500-1000 mg/day in middle-aged and older adults. Preclinical toxicology found no genotoxic effects, with a no-observed-adverse-effect level of roughly 557-617 mg/kg bodyweight/day in human-equivalent terms. Long-term safety beyond several months has not been studied. Direct oral supplementation bypasses the variability of gut bacteria needed to convert dietary ellagitannins into urolithin A, so supplement-form doses reliably produce plasma levels about six times higher than pomegranate juice.
Three recent studies to know
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Targeting aging with urolithin A in humans: A systematisk översiktLäs studie →
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Assessment of Urolitin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, dubbelblind, placebokontrollerad studyLäs studie →
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Is Urolitin A (UA) a pharmacologically credible neuro-nutraceutical?Läs studie →
Landmark studies
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Andreux et al. 2019 (Nature Metabolism)
First-in-human study confirmed mitophagy induction and safety at 500 and 1000 mg.
Läs studie → -
Singh et al. 2022 (Cell Reports Medicine)
4 months at 1000 mg/day improved leg muscle strength ~12% in adults 40 to 65.
Läs studie →
Found in these produkter (9)
Alla produkter in our catalog that contain Urolitin A, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Mitochondrial →Molekyler in the same class, plus the actives most often formulated alongside Urolitin A in our catalogue.
Frequently asked questions
What is Urolitin A?
A molecule your gut bacteria make from pomegranate and berries, if you have the right bacteria. Only about 40% of people do. Urolitin A tells old, damaged mitochondria (the power plants inside cells) to recycle themselves, so cells work better.
What dose of Urolitin A should I take?
The trial dose in published human studies is 1000 mg per dag, with a range of 500 to 1000 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Urolitin A safe?
Cheap 'urolithin A precursor' produkter (pomegranate extract) don't work if you lack the right gut bacteria. Only direct Urolitin A supplements are reliable.
What is the best Urolitin A supplement?
We track 9 produkter containing Urolitin A. The top-ranked product scores 8.6 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Urolitin A?
Urolitin A has evidence grade A, meaning it is well-supported by replicated human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.