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Foundational

Vitamin A · Vitamin A (retinyl palmitate)

Fat-soluble vitamin; toxicity concerns at high doses.

A
Bevisning grade
Replicated human RCTs with hard endpoints

Short answer

Vitamin A (Vitamin A (retinyl palmitate)) is a foundational with evidence grade A, meaning it is well-supported by replicated human trials. We track 3 produkter containing Vitamin A. Typical doses range from 0.0708 to 3.0 mg per portion. The top-ranked product scores 6.5 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $90.00 per månad.

Bevisning grade: A Produkter in database: 3 Kategori: Foundational

Top Vitamin A produkter

ProductVarumärkeDosePris/mo3rd-party testedPoäng
Seed DM-02 Daily Multivitamin0.9 mg$39.99Yes6.5
Extra Virgin Cod Liver Oil (Liquid)3.0 mg$47.99Yes6.4
Mosaic0.0708 mg$90.00No5.6

Scores are editorial judgments, not a scientific standard. Se how we score.

What it is

Essential for vision, immune function, skin. Overdose (>10,000 IU/day) causes toxicity, especially in pregnancy.

Why people take it

Correcting deficiency important in restricted diets. Casual megadosing dangerous.

Our verdict

Get from diet (liver, eggs, orange vegetables via beta-carotene). Only supplement if diagnosed deficient.

Structure & class

Retinol / retinyl esters.

Mechanism & clinical data

Teratogenicity above 10,000 IU/day in pregnancy.

Pharmacokinetics

Days.

Dose & forms

Trial dose
0.9 mg
/ day
Range in trials
0.7 to 3 mg
/ day
Common forms
Retinyl palmitate, Beta-carotene (safer)

What to watch out for

Do not exceed 10,000 IU/day. Pregnancy hazard.

Säkerhet limits and interactions

When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.

Tolerable upper intake level (UL)
3 mg/day
Known drug interactions
Retinoids may interact with oral contraceptives (reduced effectiveness), tetracyclines (increased intracranial pressure risk), and anticoagulants. Avoid high-dose preformed vitamin A during pregnancy.
Säkerhet note
UL is 3,000 μg RAE/day (3 mg/day) for adults from preformed vitamin A (retinol/retinyl esters). Chronic excess intake is associated with hip fracture, liver toxicity, and teratogenic effects. Beta-carotene is not subject to this UL.

Source: https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regelverk status

EUFood supplement (limit 800 μg RE)
USDietary supplement
UKFood supplement
CANHP

Timeline

Regelverk events, evidence grade changes, and key research milestones for Vitamin A, most recent first. Every entry links to its primär source.

  • 2025-04 Regelverk single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regelverk confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
  • 2006-12 Regelverk confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
  • 1997 Regelverk confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.

Landmark studies

    Found in these produkter (3)

    Alla produkter in our catalog that contain Vitamin A, ranked by our overall score. Ranking is editorial, never paid.

    Redaktionellt guides

    Buying guides and comparisons

    Neighbouring molecules

    Related ingredients

    Se alla in Foundational →

    Molekyler in the same class, plus the actives most often formulated alongside Vitamin A in our catalogue.

    Omega-3 (EPA/DHA)Asame categoryVitamin D3Asame categoryVitamin K2Bsame categoryMagnesiumAsame categoryVitamin B12Asame categoryFolate (5-MTHF)Bsame categoryZincAsame categorySeleniumAsame category

    Frequently asked questions

    What is Vitamin A?

    Essential for vision, immune function, skin. Overdose (>10,000 IU/day) causes toxicity, especially in pregnancy.

    What dose of Vitamin A should I take?

    The trial dose in published human studies is 0.9 mg per dag, with a range of 0.7 to 3 mg per dag. Always consult a qualified clinician before starting any supplement.

    Is Vitamin A safe?

    Do not exceed 10,000 IU/day. Pregnancy hazard.

    What is the best Vitamin A supplement?

    We track 3 produkter containing Vitamin A. The top-ranked product scores 6.5 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

    What is the evidence grade for Vitamin A?

    Vitamin A has evidence grade A, meaning it is well-supported by replicated human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

    Independently checked

    Data verification

    Bevisning grade
    A
    Replicated human RCTs with hard endpoints
    Research dose
    0.9 mg
    Verified n/a
    Produkter tracked
    3
    Uppdaterad continuously
    Säkerhet signal
    Do not exceed 10,000 IU/day. Pregnancy hazard.
    Verified n/a

    Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.