Vitamin B12 · Methylcobalamin
Deficiency common over 50 and in vegetarians; correcting it is essential.
Short answer
Vitamin B12 (Methylcobalamin) is a foundational with evidence grade A, meaning it is well-supported by replicated human trials. We track 2 produkter containing Vitamin B12. Typical doses range from 0.0024 to 0.5 mg per portion. The top-ranked product scores 7.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $40.00 per månad.
Top Vitamin B12 produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Matter | 0.5 mg | $40.00 | Yes | 7.3 | |
| Seed AM-02 Energy + Focus | 0.0024 mg | $34.99 | Yes | 5.4 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
A B-vitamin your body needs for red blood cells and nerve function. Naturally in meat, fish, eggs, dairy. After ~50, stomach acid drops and absorption falls even with adequate intake.
Why people take it
Deficiency causes anemia, neuropathy, and cognitive decline. Correcting deficiency is one of the highest-return interventions in older adults.
Our verdict
Test blood B12 (or MMA if borderline). If low, sublingual methylcobalamin 1000 μg/day. Don't buy expensive 'active' B12 sprays unless deficient.
Structure & class
Cobalamin, methylated form. Cofactor for methionine synthase.
Mechanism & clinical data
IF-B12 pathway declines with age. Sublingual/high-dose oral bypasses IF requirement.
Pharmacokinetics
Days to months (liver storage).
Dose & forms
What to watch out for
Metformin depletes B12; check yearly if on it.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Vitamin B12, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
Found in these produkter (2)
Alla produkter in our catalog that contain Vitamin B12, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Foundational →Molekyler in the same class, plus the actives most often formulated alongside Vitamin B12 in our catalogue.
Frequently asked questions
What is Vitamin B12?
A B-vitamin your body needs for red blood cells and nerve function. Naturally in meat, fish, eggs, dairy. After ~50, stomach acid drops and absorption falls even with adequate intake.
What dose of Vitamin B12 should I take?
The trial dose in published human studies is 1 mg per dag, with a range of 0.5 to 5 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Vitamin B12 safe?
Metformin depletes B12; check yearly if on it.
What is the best Vitamin B12 supplement?
We track 2 produkter containing Vitamin B12. The top-ranked product scores 7.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Vitamin B12?
Vitamin B12 has evidence grade A, meaning it is well-supported by replicated human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.