Vitamin B6 (P-5-P) · Pyridoxal-5-Phosphate
Active form of B6; toxicity concerns at high doses of pyridoxine.
Short answer
Vitamin B6 (P-5-P) (Pyridoxal-5-Phosphate) is a foundational with evidence grade A, meaning it is well-supported by replicated human trials. We track 3 produkter containing Vitamin B6 (P-5-P). Typical doses range from 3.3 to 20.0 mg per portion. The top-ranked product scores 7.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $99.00 per månad.
Top Vitamin B6 (P-5-P) produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Matter | 20.0 mg | $40.00 | Yes | 7.3 | |
| AGZ: Nightly Sleep Support | 5 mg | $99.00 | Yes | 6.5 | |
| Vital Proteins Beauty Boost Capsules | 3.3 mg | $30.00 | No | 5.8 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
Essential B-vitamin. Active form (P-5-P) safer than plain pyridoxine hydrochloride at doses above 25 mg/day.
Why people take it
Deficiency causes neuropathy, as does excess (>50 mg pyridoxine/day chronically).
Our verdict
Use P-5-P at low doses (10 to 25 mg). Ignore high-dose 'PMS relief' claims.
Structure & class
Pyridoxal-5-phosphate; cofactor for transamination.
Mechanism & clinical data
Vrolijk 2017 documented pyridoxine neuropathy at chronic >50 mg.
Pharmacokinetics
Days.
Dose & forms
What to watch out for
Don't chronically exceed 50 mg/day of pyridoxine.
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Vitamin B6 (P-5-P), most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Landmark studies
Found in these produkter (3)
Alla produkter in our catalog that contain Vitamin B6 (P-5-P), ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Foundational →Molekyler in the same class, plus the actives most often formulated alongside Vitamin B6 (P-5-P) in our catalogue.
Frequently asked questions
What is Vitamin B6 (P-5-P)?
Essential B-vitamin. Active form (P-5-P) safer than plain pyridoxine hydrochloride at doses above 25 mg/day.
What dose of Vitamin B6 (P-5-P) should I take?
The trial dose in published human studies is 20 mg per dag, with a range of 10 to 25 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Vitamin B6 (P-5-P) safe?
Don't chronically exceed 50 mg/day of pyridoxine.
What is the best Vitamin B6 (P-5-P) supplement?
We track 3 produkter containing Vitamin B6 (P-5-P). The top-ranked product scores 7.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Vitamin B6 (P-5-P)?
Vitamin B6 (P-5-P) has evidence grade A, meaning it is well-supported by replicated human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.