Vitamin K2 · Vitamin K2 (MK-7)
Vitamin D3's essential partner, directs calcium to bones instead of arteries.
Short answer
Vitamin K2 (Vitamin K2 (MK-7)) is a foundational with evidence grade B, meaning it is supported by human RCTs. We track 6 produkter containing Vitamin K2. Typical doses range from 0.09 to 43.0 mg per portion. The top-ranked product scores 8.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $59.00 per månad.
Top Vitamin K2 produkter
| Product | Varumärke | Dose | Pris/mo | 3rd-party tested | Poäng |
|---|---|---|---|---|---|
| Vitamin D3+K2 | 0.09 mg | $19.95 | Yes | 8.3 | |
| Basic Nutrients 2/Day | 0.4 mg | $32.00 | Yes | 7.4 | |
| AG Vitamin D3+K2 | 0.1 mg | $29.00 | Yes | 7.0 | |
| Seed DM-02 Daily Multivitamin | 43.0 mg | $39.99 | Yes | 6.5 | |
| Vital Proteins Bioactive Collagen Complex Bone & Joint Support | 0.12 mg | $59.00 | Yes | 6.5 |
Scores are editorial judgments, not a scientific standard. Se how we score.
What it is
A form of vitamin K found in fermented foods (natto, aged cheese). It activates proteins that direct calcium into bones and teeth and keep it out of arteries and soft tissues.
Why people take it
The 3-year Knapen trial (2013) showed 180 μg MK-7/day slowed arterial stiffening and improved bone density in postmenopausal women. K2 status is critical when supplementing D3.
Our verdict
Buy this as a D3+K2 combo unless you specifically need one alone. MK-7 form has 3× longer half-life than MK-4.
Structure & class
Menaquinone-7 (all-trans). Activates osteocalcin (bone) and matrix Gla protein (arterial calcium inhibitor).
Mechanism & clinical data
Knapen 2013 showed 3 years of 180 μg MK-7/day improved bone-mineral density and reduced arterial stiffening (aortic pulse-wave velocity). MK-4 requires 45 mg/day (Japan) whereas MK-7 works at 180 μg.
Pharmacokinetics
~72 hours (MK-7); ~1 hour (MK-4).
Dose & forms
What to watch out for
Interacts with blood thinners (warfarin), consult your doctor. All-trans MK-7 is the active form; cis-MK-7 is inactive filler.
Säkerhet limits and interactions
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
Source: https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/
Where this dose comes from
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regelverk status
Timeline
Regelverk events, evidence grade changes, and key research milestones for Vitamin K2, most recent first. Every entry links to its primär source.
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EU Court sharpens the bar for botanical health claimsA Court of Justice of the European Union ruling in april 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
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EU report identifies 117 supplement substances as potential health risksThe HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
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Knapen et al. 2013 (Thromb Haemost)180 μg MK-7 daily for 3 years slowed arterial stiffening in postmenopausal women.
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EU Health Claims Regulation adoptedRegulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
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EU introduces the Novel Food RegulationRegulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 maj 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
Vitamin K2 (MK-7) activates proteins that direct calcium into bone and away from arteries, slowing vascular calcification in trials.
Verified 2026-08-04. We update this section as new peer-reviewed trials land.
Best-supported claim
Vitamin K2's best-supported effect is slowing vascular and valvular calcification through activation of matrix Gla protein (MGP), a calcification inhibitor. The AVC Trial, the largest K2-specific RCT to date, found MK-7 plus vitamin D3 slowed aortic valve calcification progression over 24 months in 365 elderly men (https://pmc.ncbi.nlm.nih.gov/articles/PMC12785717/table/ijms-27-00298-t003/). Smaller trials reinforce this mechanism: a 6-month RCT in 68 people with type 2 diabetes and cardiovascular disease found MK-7 (360 mcg/day) improved arterial stiffness and reduced uncarboxylated MGP, and a 3-year trial in 244 healthy postmenopausal women found MK-7 (180 mcg/day) improved arterial elasticity. A 2023 systematisk översikt of 14 RCTs found consistent reductions in the uncarboxylated (inactive) MGP biomarker across studies, though outcome data on hard clinical endpoints like heart attacks remains limited.
Not supported by the evidence base
Marketers frequently claim vitamin K2 prevents heart attacks and strokes directly, but no trial has yet shown this. The evidence base consists of surrogate markers (arterial stiffness, calcification scores, MGP biomarkers) and small-to-moderate trials, not hard cardiovascular event reduction in a large outcomes trial. A 2024 metaanalys of vitamin K supplementation and cardiovascular risk factors examined markers like blood glucose, lipids, and blood pressure and found effects, but these are risk-factor changes, not confirmed reductions in heart attacks or strokes (https://pubmed.ncbi.nlm.nih.gov/38282652/). For bone health, the evidence is genuinely mixed rather than uniformly positive: a 2019 updated metaanalys of 36 studies found vitamin K reduced clinical fracture odds in postmenopausal or osteoporotic patients (OR 0.72), but this differs by vitamin K form and population, and general healthy-adult bone density claims are not as strongly supported as the osteoporosis-specific fracture data (https://link.springer.com/article/10.1007/s00198-019-04949-0).
Typical dose
90-360 mcg/day of MK-7 (menaquinone-7), the long-acting form; some cardiovascular trials use up to 720 mcg/day
Säkerhet
Vitamin K2 has a strong safety record in trials up to 24 months, including in dialysis patients, with no significant excess adverse events reported versus placebo. The RenaKvit study in 190 hemodialysis patients found MK-7 was safe and well tolerated over 24 months (https://pmc.ncbi.nlm.nih.gov/articles/PMC12785717/table/ijms-27-00298-t003/). The main clinical caution is for people on warfarin or other vitamin K antagonist blood thinners, where vitamin K intake directly counteracts the drug's mechanism and must be kept consistent and medically supervised.
Interactions worth flagging
- warfarin and other vitamin K antagonist blood thinners
Three recent studies to know
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Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blind Clinical TrialLäs studie →
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Effects of vitamin K supplementation on bone mineral density and osteocalcin carboxylation: a metaanalys and systematisk översikt of randomized controlled trialsLäs studie →
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Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematisk översikt and metaanalys of randomized controlled trialsLäs studie →
Landmark studies
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Knapen et al. 2013 (Thromb Haemost)
180 μg MK-7 daily for 3 years slowed arterial stiffening in postmenopausal women.
Läs studie →
Found in these produkter (6)
Alla produkter in our catalog that contain Vitamin K2, ranked by our overall score. Ranking is editorial, never paid.
Buying guides and comparisons
Related ingredients
Se alla in Foundational →Molekyler in the same class, plus the actives most often formulated alongside Vitamin K2 in our catalogue.
Frequently asked questions
What is Vitamin K2?
A form of vitamin K found in fermented foods (natto, aged cheese). It activates proteins that direct calcium into bones and teeth and keep it out of arteries and soft tissues.
What dose of Vitamin K2 should I take?
The trial dose in published human studies is 0.18 mg per dag, with a range of 0.09 to 0.36 mg per dag. Always consult a qualified clinician before starting any supplement.
Is Vitamin K2 safe?
Interacts with blood thinners (warfarin), consult your doctor. All-trans MK-7 is the active form; cis-MK-7 is inactive filler.
What is the best Vitamin K2 supplement?
We track 6 produkter containing Vitamin K2. The top-ranked product scores 8.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
What is the evidence grade for Vitamin K2?
Vitamin K2 has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Data verification
Bevisning grades are reviewed when new human RCTs are published. Product counts update automatically as new produkter are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.