Glycine Powder

Kumar et al. 2021 (Clin Transl Med)

Glycine Powder

Name: Glycine Powder
Brand: BulkSupplements
SKU: bulk-glycine
Price: 20.0 USD
Availability: InStock

Amino acid · Powder · 100 portioner#1 / 11 in Amino acid

8.3

Overall score · out of 10

8.3

Overall score · out of 10

Dose vs. studies8.0

Transparency9.0

Value9.9

Community9.0

Formulation5.0

Tier 3

Ingredient RCT (matching dose)

The ingredient was tested in an RCT at the same dose this product sells.

Redaktionellt score, paid $0 No affiliate link Tested by independent lab Public analysintyg Sample received: No

How we scored this product Show the full breakdown

Dose vs. studies (55%) 8.0

Transparency (20%) 9.0

Value (10%) 9.9

Community sentiment (10%) 9.0

Formulation (5%) 5.0

Composite 8.3

8.3 composite

Dose vs. studies55%8.0

Transparency20%9.0

Value10%9.9

Community10%9.0

Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Glycine Grade B

Cheap amino acid with better sleep and glutathione-precursor benefits.

1 landmark RCT · US: Dietary supplement / GRAS · EU: Food supplement

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

100% av studiedosen

Meets or exceeds the published effective dose

Cost at trial dose

$0.20/day at trial dose

What one effective daily dose actually costs

Transparency

9.0/10 · Public analysintyg (quality: not assessed)

Independent batch testing confirmed

Consumer signals

No consumer signals collected yet

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Säkerhet signals

Drug interaction risk — glycine

maj reduce the efficacy of clozapine.

Läs mer

No major red flags

Public analysintyg, tested by independent lab, dose within range

No safety, transparency, or dose concerns detected at this time.

Best for

Full trial dose, Public analysintyg, Budget-friendly

Avoid if

No major red flags

Full-dose status

Meets trial dose

Pris/month

COA status

Public

Biggest caveat

No significant caveats at this time.

Nearest alternatives

Longevity Mix - Blood Orange Blueprint · Poäng 6.5
AGZ: Nightly Sleep Support AG1 (Athletic Greens) · Poäng 6.5
Glycine Supplement Double Wood Supplements · Poäng 6.4

The numbers

Pris

$20

per bottle · 100 portioner

Dose vs. research

Överensstämmer med studier 100%

of published effective dose

$ / day at studied dose

$0.20

what one effective daily dose costs

$ / g active

$0.07

per gram of active substance

Independently checked

Data verification

Pris

$20

Verified n/a

Dose

100% av studiedosen

Verified n/a

COA status

Public

Verified n/a

Bevisning grade

Per-ingredient breakdown

BGlycine

Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Bevisning

Glycine

Cheap amino acid with better sleep and glutathione-precursor benefits.

3000 mg 100% av studiedosen

3000 mg

Consumer signals

Consumer signals gathered from 1 platform.

Low confidence, small sample

Consumer sentiment compiled from 1 public source (Examine.com). Small sample size, treat as directional only.

Examine.com

positive sentiment

PraiseGlycine well-tolerated at 3 g/day. GlyNAC protocol popular with older adults.

Compiled from a Examine.com listing located during manual research; not independently re-verified against the live page at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

ConsumerLab.com, Glycine Supplements Review

No affiliate relationship Not a paid placement

ConsumerLab's independent testing found no potency or contamination red flags for BulkSupplements' glycine powder specifically, while noting more broadly that price does not track quality for glycine since all tested produkter contain the same free-form molecule.

Finding: BulkSupplements.com Glycine Powder was one of 10 glycine produkter lab-tested (HPLC-UV-VIS potency, ICP-MS heavy metals) in ConsumerLab's april 2025 review; all 10 tested produkter, including this one, contained their labeled amount of glycine within an acceptable margin, with heavy metals not concerning/mostly non-detectable, and the review separately found this product priced among the cheapest per 3 g dose of the cohort (competing produkter ranged 9 cents to over $1.00 per 3 g dose).

How we use it: Primär Tier A source for third-party purity/potency verification of this exact product. This is the strongest independent quality evidence available for this SKU and outweighs the brand's self-reported, request-only COA policy.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

verifiedsupplementdata.com, Best Glycine Supplement (2026): Same Molekyl, 12x Pris Gap

Has affiliate relationship Not a paid placement

Treats BulkSupplements as the rational buy on a cost-per-dose basis given that all tested glycine produkter are chemically identical free-form glycine.

Finding: Names BulkSupplements Glycine Powder (1 kg) as 'best overall value,' citing 999 g of glycine for $32.97 (~$0.033/gram, ~$0.10 per 3 g dose), referencing ConsumerLab's 2025 test as the quality basis.

How we use it: Corroborating Tier B source for price-per-dose figures; site's affiliate/commercial model is not disclosed on-page, so we use it only to cross-check pricing math already independently verifiable from retailer listings, not for any quality claim beyond what ConsumerLab established.

Trustpilot, BulkSupplements.com (US storefront)

No affiliate relationship Not a paid placement

Mixed-to-moderately-positive sentiment on product quality and value; the most common complaints are logistics/fulfillment issues rather than ingredient efficacy or safety, though a meaningful minority of reviews are strongly negative.

Finding: 694 total reviews on the US Trustpilot listing; an AI-generated summary of a 415-review sample describes reviewers as 'somewhat happy' overall, praising purity/effectiveness and pricing, while flagging inconsistent product texture, shipping/delivery problems, and occasional order errors.

How we use it: Used as brand-level (not product-specific) community sentiment; N is large enough to be meaningful per the brief's Tier B threshold (N>500 across the review base), but Trustpilot ratings vary sharply by storefront/region (see below), so we treat this as directionally mixed rather than strongly positive or negative.

Trustpilot, BulkSupplements.com (UK storefront)

No affiliate relationship Not a paid placement

The UK storefront's Trustpilot record is substantially worse than the US storefront's, suggesting international fulfillment/support is a bigger pain point than US domestic service.

Finding: UK Trustpilot listing shows an overall rating of 2.0/5 ('Poor') across 284 reviews, with the company replying to only about 8% of negative reviews.

How we use it: Included to give a full, unfiltered picture, the brief specifically calls for the same Trustpilot treatment as the taurine dossier, and BulkSupplements' Trustpilot scores vary widely by region/domain (German storefront shows 3.6/5 on ~633 reviews), so a single global 'Trustpilot score' would be misleading. We report all three regional figures rather than cherry-picking the most favorable one.

Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Reddit r/Supplements, 'Lets talk about glycine'

No affiliate relationship Not a paid placement

Anecdotal community experience aligns directionally with the published sleep-quality RCT literature on dose (3 g, pre-bed).

Finding: No quantitative rating; qualitative consensus in the thread is that glycine helps sleep at doses of at least 3 g taken before bed on an empty stomach, consistent with the Bannai/Inagawa/Yamadera RCT dose.

How we use it: Used only as a directional, low-weight signal that community self-reported experience matches the RCT-established dose; not used as independent quality/safety evidence per Tier C limitations.

Reddit r/nutrition, 'L-Glycine: real deal or waste of $$?'

No affiliate relationship Not a paid placement

Mixed individual anecdotes, most threads found are positive on sleep, but negative/paradoxical responses are also reported by a minority of users.

Finding: No quantitative rating; at least one commenter reports glycine caused sleep disturbances rather than improving sleep, illustrating individual variability.

How we use it: Used to balance the otherwise uniformly positive anecdotal sleep reports; included specifically to avoid survivorship bias toward positive-only testimonials.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Examine.com

positive

Glycine well-tolerated at 3 g/day. GlyNAC protocol popular with older adults.

Read source → Unverified · we received no payment for this listing

Vår sammanfattning

BulkSupplements.com Glycine Powder is a single-ingredient, 3,000 mg-per-serving free-form glycine powder sold in several pack sizes at one of the lowest per-gram prices in the category, and it is one of the few glycine produkter with direct independent lab verification via ConsumerLab's 2025 testing. Its evidence tier rests on Tier 3 human RCT support for its exact 3 g dose in the context of sleep quality (Bannai et al. 2012 and earlier related trials), while the mouse-lifespan finding (Miller et al. 2019) and the GlyNAC aging-biomarker trial (Kumar et al. 2023) provide genuine but indirect longevity-adjacent support, the former from animal data at a very different dosing paradigm, the latter for glycine only as one half of a combination with NAC at a considerably higher, bodyweight-scaled dose than this product's fixed 3 g serving. The single most important thing a buyer needs to know: this is a well-verified commodity ingredient at an excellent price for its established sleep-quality use case, but buyers hoping to replicate the GlyNAC longevity protocol specifically will need roughly double to triple this product's portionstorlek of glycine (and a separate NAC product) to match the dose actually tested in older adults.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 3Ingredient RCT (matching dose)

3 studies mapped

Tier 3Ingredient RCT (matching dose)

The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers

Bannai M, Kawai N, Ono K, Nakahara K, Murakami N · 2012 · Frontiers in Neurology · n=20 · 3,000 mg (3 g) glycine, ingested 30 minutes before bedtime · Randomized single-blinded crossover, 3 consecutive nights per condition

ingredient-levelpeer-reviewed

3 g glycine before bed significantly reduced next-day fatigue and sleepiness (visual analog scale) versus placebo and significantly improved psychomotor vigilance test performance, without altering plasma melatonin.

Dose matches BulkSupplements' exact 3,000 mg portionstorlek. This is the strongest direct human RCT evidence for the product's labeled dose and is consistent with earlier Bannai/Inagawa/Yamadera trials at the same 3 g dose (J Pharmacol Sci 2012, PMID 22293292; Sleep Biol Rhythms 2007).

Conflicts: Författare are employed by Ajinomoto Co., Inc. (a commercial amino-acid manufacturer with a financial interest in glycine sales), a real conflict of interest to disclose, though the trial design and independent replications (Inagawa 2006, Yamadera 2007) support the core finding.

Source →

Tier 3Ingredient RCT (matching dose)

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV · 2023 · The Journals of Gerontology: Series A (J Gerontol A Biol Sci Med Sci) · n=36 · 100 mg/kg/day glycine + 100 mg/kg/day N-acetylcysteine (combined 'GlyNAC'; placebo arm received 200 mg/kg/day alanine) · 16 weeks (older adults); 2 weeks (young-adult comparator arm)

ingredient-levelpeer-reviewed

GlyNAC (not placebo) supplementation in older adults restored red-blood-cell glutathione by 164% at 16 weeks to youth-comparable levels, and significantly improved oxidative stress markers, mitochondrial fatty-acid oxidation, inflammatory markers (IL-6, TNF-alpha, hsCRP), insulin resistance, endothelial function, gait speed, muscle strength, 6-minute walk distance, waist circumference, and systolic blood pressure versus placebo.

This is the GlyNAC trial the brief specifically flags as a strong reference. It is real, peer-reviewed, and clinically meaningful, but it tests glycine strictly as one half of a fixed-ratio combination with NAC, at a bodyweight-scaled dose (100 mg/kg/day glycine is roughly 7-8.5 g/day for a 70-85 kg adult, notably higher than BulkSupplements' 3 g serving), and there is no isolated-glycine arm to attribute effects to glycine alone. It is Tier 3 evidence for the GlyNAC combination protocol, not Tier 3 evidence for BulkSupplements' single-ingredient glycine powder at its labeled 3 g dose; we list it here because it is the single most substantive 'aging biomarker' human trial involving glycine and because BulkSupplements sells glycine powder that consumers commonly self-stack with NAC to replicate this exact protocol.

Conflicts: Funded by NIH/NIA (R01AG059948) and USDA/ARS; no supplement-industry sponsor identified.

Source →

Tier 5Mechanistic / animal / marketing

Glycine Supplementation Extends Lifespan of Male and Female Mice

Miller RA, Harrison DE, Astle CM, et al. · 2019 · Aging Cell · 8% glycine-supplemented diet (substituted isocalorically for other amino acids) · Lifelong dietary intervention from mid-adulthood

ingredient-levelpeer-reviewed

8% dietary glycine produced a small but statistically significant 4-6% increase in median lifespan and an increase in maximum lifespan in both sexes, replicated across all three ITP test sites.

This is the primär mouse-longevity evidence the brief asks about. It used a very high dietary percentage (8% of total diet) rather than a fixed gram dose, so it does not translate directly to a human daily-mg equivalent, and mice are not humans, this is Tier 5 (animal/mechanistic) support for a longevity narrative, not proof that 3 g/day in a human extends lifespan.

Conflicts: Funded by NIA Interventioner Testing Program (US government); no commercial supplement sponsor identified.

Source →

Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Glycine Kumar et al. 2021 (Clin Transl Med)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Supported

“Sleep Support: Glycine is commonly used to help promote restful sleep and relaxation. It may support healthy sleep patterns as part of an evening wellness routine.”

This is well-supported by a consistent line of small human RCTs at exactly the product's 3,000 mg portionstorlek, including Bannai et al. 2012 (Frontiers in Neurology, PMID 22529837) and earlier Inagawa 2006 / Yamadera 2007 trials, all showing improved subjective sleep quality and/or reduced next-day fatigue at 3 g pre-bed. Effect sizes are modest and studies are small (n=11-20), so 'may support' is appropriately hedged language, but the core claim holds up.

Unverifiable

“Versatile Amino Acid Support: As a non-essential amino acid, Glycine supports multiple systems in the body.”

This is a vague structure/function statement, not a specific, testable health claim. Glycine is indeed a conditionally essential amino acid used in collagen, glutathione, and creatine synthesis, but the claim as written makes no falsifiable assertion we can verify or refute against a specific endpoint.

Not supported

“Pre-Workout Beverages: Blending glycine into your pre-workout drink helps to not only boost your energy but also protects muscle mass during exercise.”

We found no human RCT evidence that isolated glycine supplementation at typical consumer doses boosts pre-workout energy or protects muscle mass during exercise. Glycine is a collagen/creatine precursor and this claim likely leans on that indirect biochemical role, but no direct exercise-performance or muscle-preservation trial for supplemental glycine was located.

Partial support

“Glycine is a simple and effective addition to daily wellness routines that supports multiple systems in the body.”

True for sleep specifically (see above), but 'multiple systems' is marketing generality that overstates the scope of directly tested human benefits, which are concentrated in sleep quality/fatigue and, in combination with NAC (GlyNAC), glutathione and metabolic aging markers, not glycine alone across 'multiple systems.'

BulkSupplements profile →

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

No published Certificate of Analysis is posted on the product page itself; a batch-specific COA must be requested via https://www.bulksupplements.com/coa-request or by emailing [email protected], so buyers cannot see the exact lab results for the batch they receive without an extra step.
The exact third-party laboratory name used for outside verification is not publicly disclosed by BulkSupplements; the company describes its testing methods (ICP-MS, FTIR, UV-Vis, microbiology) but not the specific accredited lab performing them.
We could not confirm from the vendor page alone whether BulkSupplements' glycine is manufactured via traditional fermentation/synthesis versus a specific proprietary process; the 'Other Ingredienser: None' label claim was cross-confirmed via retailer mirrors (Target, Amazon) rather than a live vendor-page fetch, since the live page timed out during this research pass.
It is not confirmed whether the specific batch(es) sold today are among the exact units ConsumerLab purchased and tested in its april 2025 review, ConsumerLab results reflect specific lots purchased at that time, not an ongoing per-batch guarantee.
BulkSupplements' own on-site customer review count/rating (frequently cited by the brand as ~4.6 stars from thousands of reviews) could not be independently verified for authenticity or moderation practices, in contrast with the much lower, verifiably-collected Trustpilot scores discussed below.
No information was found on whether this specific SKU is vegan-sourced or animal-derived at the raw-material level; free-form glycine can be produced synthetically or via fermentation, and BulkSupplements does not specify the production method on its label copy we could access.
Trustpilot aggregator

3.3/5715 reviews

This is a brand-level customer-service profile for bulk-supplements; it does not isolate Glycine Powder.

verified 2026-08-07Open source →
Reddit r/Supplements community forum

mixed sentiment

Community discussion exists around glycine powder, with users mainly describing possible sleep benefits while noting dose-related drowsiness or morning grogginess. No single Reddit thread is treated as a representative product review.

no direct URLchecked 2026-08-07
BulkSupplements on-site reviews own platform

4.6/55076 reviews

BulkSupplements displays a first-party, brand-level review total on its public page; it does not isolate glycine.

verified 2026-08-07Open source →

Important to know

GlycineNone major. Very sweet in powder form, mix in water or coffee.

Redaktionellt notes

GlyNAC protocol ingredient (with NAC).

In plain language

Why this scored this way

This BulkSupplements Glycine Powder scores 8.3, making it a strong scorer. It delivers the full 3000mg trial dose of Glycine with grade B evidence (promising human data, not yet comprehensive). Transparency is a clear strength (score: 9.0), with third-party testing and a public analysintyg. At $0.20/day it's priced well for what you get.

What drives the score up

Dose-evidence score of 8.0 reflects good alignment with trial doses.
Quality transparency of 9.0: tested by independent lab with a public analysintyg.
Value score of 9.9 at $0.20/day.
Community score of 9.0 with positive consumer feedback.
Glycine is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

No significant weaknesses identified in the current scoring framework.

Why you'd choose it

You want good value at $0.20/day.
You want Glycine from a BulkSupplements product.
You prioritise tested by independent lab produkter with public lab certificates.

Why you might skip it

You want a product in a different category.
You want a cheaper amino acid option.
You prefer produkter with more consumer feedback.

Go deeper

Where this sits

Actives inside

Glycine

Kategori

Se alla in Amino acid →

Varumärke

Jämför this product → Visit brand site →

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Glycine Powder and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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