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Betaine Anhydrous (TMG) Powder

Methyl donor · Powder (240-capsule variant also sold) · 66 portioner#5 / 5 in Methyl donor
5.6
Overall score · out of 10
5.6
Overall score · out of 10
Dose vs. studies4.7
Transparency6.0
Value9.3
Community6.0
Formulation5.0
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
Redaktionellt score, paid $0 No affiliate link No third-party test No public analysintyg Sample received: No
How we scored this product Show the full breakdown
Composite How this 5.6 is built. 0.55 × 4.7 + 0.20 × 6.0 + 0.10 × 9.3 + 0.10 × 6.0 + 0.05 × 5.0 = 5.6 out of 10. Säkerhet caps applied after. 5.6
5.6 composite
Dose vs. studies55%4.7
Transparency20%6.0
Value10%9.3
Community10%6.0
Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
50% av studiedosen
Below the full trial dose
Cost at trial dose
$0.61/day at trial dose
What one effective daily dose actually costs
Transparency
6.0/10 · No public analysintyg
No third-party testing disclosed
Consumer signals
694 reviews across platforms · 2.0/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No public analysintyg
Certificate of Analysis not published
Without a public analysintyg, batch purity and potency cannot be independently verified.
No third-party testing
Independent lab verification not disclosed
The brand does not publish evidence of independent batch testing.
Buyer complaints
Trustpilot: customer service complaints; Trustpilot: shipping issues
Recurring themes from consumer review platforms.
Redaktionellt verdict

Quick verdict

5.6 / 10
Best for
Budget-friendly
Avoid if
Only 50% av studiedosen, No public analysintyg
Full-dose status
50% av studiedosen
Pris/month
$9
COA status
Not public
Biggest caveat
Dose is 50% of the trial dose.
Nearest alternatives

The numbers

Pris
$20
per bottle · 66 portioner
Dose vs. research
Below trial dose 50%
of published effective dose
$ / day at studied dose
$0.61
what one effective daily dose costs
$ / g active
$0.20
per gram of active substance
Independently checked

Data verification

Pris
$20
Verified n/a
Dose
50% av studiedosen
Verified n/a
COA status
Not public
Verified n/a
Bevisning grade
C
Per-ingredient breakdown
CBetaine (TMG)
Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Bevisning
Betaine (TMG)
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
1500.0 mg 50% av studiedosen
3000 mg
2.0 /5
High confidence Pris exceeds satisfaction
694 reviews across 4 platforms (4 sources)
Source diversity: 92%
AmazonRedditTrustpilotiHerb
Praisegood product selectioncompetitive pricing
Complaintscustomer service complaintsshipping issues
Last checked: 2026-08-07

Consumer signals

2.0 out of 5 across 694 verified reviews on 4 platforms.

Medium confidence

Consumer sentiment compiled from 4 public sources.

694 reviews · 2.0/5 · mixed sentiment

Praisegood product selectioncompetitive pricing
Complaintscustomer service complaintsshipping issues
ThemesBulkSupplements' overall Trustpilot rating is 'Poor' at around 2/5 from hundreds of reviews, driven mainly by customer service and shipping complaints rather than product quality.

Compiled from Trustpilot listing located during research; verified at build time.

positive sentiment

Praisegood value for moneyhelps with energy/methylation support
Complaintsmixability concerns for some
ThemesAmazon customers like the TMG powder's value and effectiveness for methylation support, with some noting mixability issues in liquids.

Compiled from Amazon listing located during research; verified at build time.

positive sentiment

Praisepure ingredient listaffordable bulk pricing
Complaintslimited direct BulkSupplements product reviews on iHerb
ThemesiHerb's TMG category page shows favorable sentiment for trimethylglycine supplements generally, though BulkSupplements-specific reviews are sparse there.

Compiled from iHerb listing located during research; verified at build time.

3 threads discussed · positive sentiment

Praisewell-regarded for MTHFR/methylation support
Complaintsdosing confusion between anhydrous and HCl forms
ThemesReddit's r/Supplements community views betaine anhydrous (TMG) favorably for methylation support, though there's recurring confusion versus betaine HCl.

Compiled from Reddit listing located during research; verified at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Bevisning

Research behind this product

No landmark studies linked yet. See the ingredient pages for the full evidence breakdown.

Important to know
Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination produkter) are well below the gram-level doses used in the supporting human trials.

Redaktionellt notes

A straightforward 1500mg TMG powder at a good price-per-gram; marketed mostly for exercise performance rather than as a dedicated methyl-donor for NAD+ stack users, though the dose is in the useful range for that purpose.

In plain language

Why this scored this way

This BulkSupplements Betaine Anhydrous (TMG) Powder scores 5.6, making it below the site average. It delivers 1500.0mg of Betaine (TMG) (50% of the 3000mg trial dose) with grade C evidence (mostly preclinical, limited human data). The quality transparency (6.0) is limited by the lack of third-party testing.

What drives the score up

  • Overall score of 5.6 with no single dominant strength.

What drags it down

  • Dose-evidence score of 4.7 is below average for the site.
  • No third-party testing, which caps the quality transparency.
  • Quality transparency of 6.0 is below the site average.
  • Limited consumer feedback (community score: 6.0).

Why you'd choose it

  • You want good value at $0.61/day.

Why you might skip it

  • You want third-party verified purity.
  • You want a product with a publicly available CoA.
  • You want a higher-scoring product (this scores 5.6).
Go deeper

Where this sits

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Betaine Anhydrous (TMG) Powder and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

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