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Pure NR

NAD+ booster · Powder · 30 portioner#10 / 46 in NAD+ booster
7.3
Overall score · out of 10
7.3
Overall score · out of 10
Dose vs. studies6.1
Transparency9.5
Value8.6
Community9.0
Formulation5.0
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
Redaktionellt score, paid $0 No affiliate link Tested by independent lab Public analysintyg Sample received: No
How we scored this product Show the full breakdown
Composite How this 7.3 is built. 0.55 × 6.1 + 0.20 × 9.5 + 0.10 × 8.6 + 0.10 × 9.0 + 0.05 × 5.0 = 7.3 out of 10. Säkerhet caps applied after. 7.3
7.3 composite
Dose vs. studies55%6.1
Transparency20%9.5
Value10%8.6
Community10%9.0
Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

The NAD+ precursor with the strongest safety file and EU approval.

2 landmark RCTs · US: GRAS, NDI accepted · EU: Authorised Novel Food (Commission Reg 2020/16)
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
167% av studiedosen
Meets or exceeds the published effective dose
Cost at trial dose
$1.10/day at trial dose
What one effective daily dose actually costs
Transparency
9.5/10 · Public analysintyg (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No major red flags
Public analysintyg, tested by independent lab, dose within range
No safety, transparency, or dose concerns detected at this time.
Redaktionellt verdict

Quick verdict

7.3 / 10
Best for
Full trial dose, Public analysintyg
Avoid if
No major red flags
Full-dose status
Meets trial dose
Pris/month
$55
COA status
Public
Biggest caveat
No significant caveats at this time.
Nearest alternatives

The numbers

Pris
$55
per bottle · 30 portioner
Dose vs. research
Above trial dose 167%
of published effective dose
$ / day at studied dose
$1.10
what one effective daily dose costs
$ / g active
$3.67
per gram of active substance
Independently checked

Data verification

Pris
$55
Verified n/a
Dose
167% av studiedosen
Verified n/a
COA status
Public
Verified n/a
Bevisning grade
B
Per-ingredient breakdown
BNR
Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Bevisning
NR
The NAD+ precursor with the strongest safety file and EU approval.
500 mg 167% av studiedosen
300 mg

Consumer signals

Consumer signals gathered from 1 platform.

Low confidence, small sample

Consumer sentiment compiled from 1 public source (Reddit). Small sample size, treat as directional only.

1 threads discussed · positive sentiment

PraisePopular as a cheaper alternative to Tru Niagen, though it isn't licensed Niagen®.

Compiled from a Reddit r/longevity listing located during manual research; not independently re-verified against the live page at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site
SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes
NIH DSLD registered label
DSLD ID 315492, UPC n/a
Portionstorlek2 Capsule(s)
Portioner per container30
Supplement Facts panel, verbatim
Nicotinamide Riboside700 mg

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Physician YouTube analysis — DoNotAge Longevity Sachet
Has affiliate relationship Not a paid placement

Detailed ingredient walk-through. Discount code and buy link present, so the editorial score is discarded; ingredient/dose facts extracted.

How we use it: Ingredient/dose facts only. Redaktionellt rating rejected.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot — DoNotAge (aggregated sentiment)
No affiliate relationship Not a paid placement

Aggregate score ≈ 4.3-4.5 / 5. Mood indicator only.

Finding: 4.3-4.5 / 5.
How we use it: Sentiment only. Never used as evidence of efficacy.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Reddit r/longevity
positive

Popular as a cheaper alternative to Tru Niagen, though it isn't licensed Niagen®.

Read source → Unverified · we received no payment for this listing

Vår sammanfattning

Pure NR is a straightforward nicotinamide riboside chloride powder/capsule product offering 350 mg per unit, positioned as a cheaper alternative to patented Niagen-brand NR produkter like Tru Niagen. The ingredient itself has solid repeat-dose human evidence for raising NAD+ (Trammell 2016, Martens 2018) at doses matching DoNotAge's higher subscription tier, and one disease-specific trial (Brakedal 2022, Parkinson's) showing a modest clinical benefit — but healthy-population functional outcomes (energy, cognition) remain thin. NR also currently sits on firmer regulatory ground than NMN in both the US and EU. Buyers should note that the clinical evidence base is built on a different branded raw material than DoNotAge's own supply.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 3Ingredient RCT (matching dose)
3 studies mapped
Tier 3Ingredient RCT (matching dose)
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell SA, Schmidt MS, Weidemann BJ, et al. · 2016 · Nature Communications · n=12 · 100, 300, and 1000 mg single doses · Single-dose pharmacokinetic study
ingredient-levelpeer-reviewed
This first human pharmacokinetic study of NR established that oral NR is well absorbed and raises whole-blood NAD+ metabolites in a dose-dependent way, providing the foundational human safety and absorption data for NR supplementation generally.
Single-dose pharmacokinetics only — it measured absorption and blood metabolite changes after one dose, not repeated daily use or clinical outcomes. The 1000 mg dose tested is close to DoNotAge's higher subscription tier but well above its base 350-700 mg/day option.
Conflicts: Some co-authors were affiliated with ChromaDex (patent holder of Niagen-brand NR); this is a widely cited disclosure in NR literature.
Tier 4Ingredient RCT (different dose)
Nicotinamide riboside supplementation for chronic dosing in healthy middle-aged and older adults
Martens CR, Denman BA, Mazzo MR, et al. · 2018 · Nature Communications · n=24 · 1000 mg/day · 6 weeks
ingredient-levelpeer-reviewed
Six weeks of 1000 mg/day NR raised whole-blood NAD+ substantially and was well tolerated, but produced no significant improvements in blood pressure, arterial stiffness, or other cardiovascular/metabolic markers measured in the study.
This is a genuinely useful negative-outcome trial: it confirms NR reliably raises NAD+ at 1000 mg/day, but shows that boosting NAD+ alone did not translate into measurable cardiovascular benefit in this healthy older cohort over six weeks — a useful caution against assuming NAD+ elevation automatically improves health markers.
Conflicts: Academic (University of Colorado Boulder); funded by NIH grants.
Tier 4Ingredient RCT (different dose)
Nicotinamide riboside efficacy in Parkinson's disease
Brakedal B, Dölle C, Riemer F, et al. · 2022 · Cell Metabolism · n=30 · 1000 mg/day · 30 days
ingredient-levelpeer-reviewed
In this Parkinson's disease trial, NR raised brain and blood NAD+ levels and produced modest improvements on a clinical motor-symptom scale, offering one of the few examples where an NR-related clinical endpoint (rather than just a biomarker) moved in a positive direction.
Encouraging but disease-specific: it applies to Parkinson's patients, not the healthy-aging population DoNotAge markets to, and cannot be generalized to claims about general cognitive benefit in healthy consumers.
Conflicts: Academic (University of Bergen); no disclosed link to DoNotAge.
Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

No evidence
“Pure NR is 'backed by research showing support for brain function and focus'”
No specific citation is given for cognitive/focus benefits in healthy users; the closest relevant human data (Brakedal 2022) is in Parkinson's patients, not a healthy-population cognitive-focus outcome.
Supported
“Pure NR restores NAD+ levels and supports mitochondrial health”
Multiple independent human trials (Trammell 2016, Martens 2018, Brakedal 2022) consistently show oral NR raises blood and tissue NAD+ in a dose-dependent way, including at doses close to DoNotAge's higher subscription tier.
Not supported
“Our Pure NR is used by leading researchers in clinical trials, not just sold as a supplement”
We could not identify a specific registered clinical trial using DoNotAge-branded NR as the study material; the major NR trials cited in the scientific literature (Trammell, Martens, Brakedal) used Niagen-brand NR from ChromaDex, not DoNotAge's product.

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

US
Legal as supplement
Nicotinamide riboside chloride has an accepted New Dietary Ingredient history in the US (originally via ChromaDex's Niagen) and has not faced the same FDA drug-preclusion dispute that affected NMN.
Senast verifierad 2026-08-05
EU
Legal as supplement
NR (as nicotinamide riboside chloride) is an approved EU Novel Food ingredient, making it currently the more legally secure NAD+ precursor for EU sale compared with NMN.
Senast verifierad 2026-08-05
UK
Legal
Sold as a standard food supplement in the UK, consistent with its EU Novel Food approval carried over post-Brexit.
Senast verifierad 2026-08-05
CA
Restricted
NR-containing produkter require a Health Canada Natural Health Product licence and NPN; DoNotAge's product does not appear to hold Canadian NPN registration.
Senast verifierad 2026-08-05

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • Whether DoNotAge's Pure NR has ever been the specific material used in an independent academic clinical trial (as opposed to Niagen/ChromaDex-brand NR) could not be confirmed.
  • The exact identity of the third-party lab used for batch purity testing was not disclosed.
Important to know
NRAlmost all commercial NR uses licensed Niagen® from ChromaDex. If a product doesn't say Niagen, ask why.

Redaktionellt notes

Non-Niagen® NR at a fraction of Tru Niagen's price.

In plain language

Why this scored this way

This DoNotAge Pure NR scores 7.3, making it a mid-tier product with both strengths and weaknesses. It delivers the full 500mg trial dose of NR with grade B evidence (promising human data, not yet comprehensive). Transparency is a clear strength (score: 9.5), with third-party testing and a public analysintyg.

What drives the score up

  • Dose-evidence score of 6.1 shows decent alignment with trial doses.
  • Quality transparency of 9.5: tested by independent lab with a public analysintyg.
  • Community score of 9.0 with positive consumer feedback.
  • NR is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

  • NR (500mg is 167% of the 300mg trial dose) is well above the trial dose. More is not always better.

Why you'd choose it

  • You want a reasonably priced nad+ booster product.
  • You want NR from a DoNotAge product.
  • You prioritise tested by independent lab produkter with public lab certificates.

Why you might skip it

  • You want a standard dose of nr (this product is well above it).
  • You want better value (this is $1.10/day with a value score of 8.6).
Go deeper

Where this sits

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Pure NR and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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