DoNotAge® routine (15-in-1 Daily Sachet)

Yi et al. 2023 (GeroScience)Okabe et al. 2022 (Frontiers in Nutrition)Uthever RCT 2022

DoNotAge® routine (15-in-1 Daily Sachet)

Name: DoNotAge® routine (15-in-1 Daily Sachet)
Brand: DoNotAge
SKU: donotage-routine
Price: 203.0 USD
Availability: InStock

Multi/greens · Powder · 28 portioner#6 / 9 in Multi/greens

6.4

Overall score · out of 10

6.4

Overall score · out of 10

Dose vs. studies5.7

Transparency8.0

Value5.0

Community9.0

Formulation5.0

Tier 4

Ingredient RCT (different dose)

The ingredient was tested in an RCT but at a different dose, or only in animals.

Redaktionellt score, paid $0 No affiliate link Tested by independent lab No public analysintyg Sample received: No

How we scored this product Show the full breakdown

Dose vs. studies (55%) 5.7

Transparency (20%) 8.0

Value (10%) 5.0

Community sentiment (10%) 9.0

Formulation (5%) 5.0

Composite 6.4

6.4 composite

Dose vs. studies55%5.7

Transparency20%8.0

Value10%5.0

Community10%9.0

Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

NMN Grade B

A NAD+ building block that has become the most-hyped longevity molecule.

5 landmark RCTs · US: FDA NDI status volatile (juli 2026) · EU: Unauthorised Novel Food (EFSA positive maj 2026, no Commission listing yet)

Betaine (TMG)Grade C

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted

CoQ10 Grade B

A well-established mitochondrial cofactor, especially useful on statins.

1 landmark RCT · US: Dietary supplement · EU: Food supplement, no Novel Food status needed

SIRT6 Activator Grade E

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

1 landmark RCT · US: Dietary supplement · EU: Food supplement (seaweed-derived)

Spermidin Grade B

The autophagy-inducing polyamine with promising cognitive data.

3 landmark RCTs · US: Dietary supplement · EU: Novel Food status for concentrates >7 mg; wheat-germ traditional food

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

200% av studiedosen

Meets or exceeds the published effective dose

Cost at trial dose

$3.62/day at trial dose

What one effective daily dose actually costs

Transparency

8.0/10 · No public analysintyg

Independent batch testing confirmed

Consumer signals

No consumer signals collected yet

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No public analysintyg

Certificate of Analysis not published

Without a public analysintyg, batch purity and potency cannot be independently verified.

Best for

Full trial dose

Avoid if

No public analysintyg, Premium pricing

Full-dose status

Meets trial dose

Pris/month

$218

COA status

Not public

Biggest caveat

No public Certificate of Analysis.

Nearest alternatives

NMN Pure Powder (Sublingual) Renue By Science · Poäng 8.4
Pure NMN Capsules Partiqlar · Poäng 7.8
NOVOS Boost NOVOS Labs · Poäng 7.4

The numbers

Pris

$203

per bottle · 28 portioner

Dose vs. research

Above trial dose 200%

of published effective dose

$ / day at studied dose

$3.62

what one effective daily dose costs

$ / g active

$1.90

per gram of active substance

Independently checked

Data verification

Pris

$203

Verified n/a

Dose

200% av studiedosen

Verified n/a

COA status

Not public

Verified n/a

Bevisning grade

BCBEB

Per-ingredient breakdown

BNMN

CBetaine (TMG)

BCoQ10

ESIRT6 Activator

BSpermidin

Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Bevisning

NMN

A NAD+ building block that has become the most-hyped longevity molecule.

1000.0 mg 200% av studiedosen

500 mg

Betaine (TMG)

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

1000.0 mg 33% av studiedosen

3000 mg

CoQ10

A well-established mitochondrial cofactor, especially useful on statins.

Q-SYMBIO 2014 (Mortensen et al., JACC)

200.0 mg 100% av studiedosen

200 mg

SIRT6 Activator

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

Rahman et al. 2014

1600.0 mg 40% av studiedosen

4000 mg

Spermidin

The autophagy-inducing polyamine with promising cognitive data.

HoA 2024 (BVL/NVWA, EU)SmartAge (Wirth et al. 2018)Jiang et al. 2026 (npj Aging)

8.0 mg 667% av studiedosen

1.2 mg

Consumer signals

Consumer signals gathered from 3 platforms.

Low confidence, small sample

Consumer sentiment compiled from Trustpilot (brand-level) and Reddit discussions. Small sample size, treat as directional only.

Trustpilot

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Independent German lab test — DoNotAge NMN capsules (Reddit r/Supplements)

No affiliate relationship Not a paid placement

A user paid €315 for a certified German laboratory (Limbach GmbH, EN ISO/IEC 17025:2018 accredited) to assay DoNotAge's NMN capsules using H-NMR and ICP-MS. Result: ~98% (±2%) purity, trace niacinamide (~0.09%), heavy metals below detectable limits, ~11% overfill vs label claim.

Finding: ~98% purity, no heavy metals, 11% overfill

How we use it: Independent physical-product verification of DoNotAge NMN. Applies to standalone NMN, not the finished sachet.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Trustpilot — DoNotAge.org aggregate reviews (8 regional domains)

No affiliate relationship Not a paid placement

Across 8 Trustpilot regional domains, DoNotAge holds 4.2-4.5/5 ratings with 267-548 reviews per domain. Praise centers on product quality, energy, mental clarity, sleep, and customer service. Complaints focus on delivery times, international shipping, subscription/pricing discrepancies, and one adverse-event report. No Trustpilot review specifically named the routine sachet product.

Finding: 4.2-4.5/5 across 8 domains, 267-548 reviews each

How we use it: Brand-level community sentiment. Applies to DoNotAge broadly, not the sachet specifically.

Dr. Brad Stanfield — physician critique of Nitralis trial (YouTube + blog)

No affiliate relationship Not a paid placement

Physician YouTuber Dr. Brad Stanfield publicly criticized the Nitralis trial: (1) measured salivary nitrite, not blood NO or clinical endpoints; (2) no independent ethics board approval; (3) delivers ~60 mg actual nitrate, ~15% of RCT doses showing vascular benefit; (4) calls the '226% increase' claim 'ungrounded' and the study 'basically worthless.'

Finding: ~60 mg actual nitrate vs ~400 mg in vascular RCTs

How we use it: Independent clinical critique of a key sachet ingredient's evidence base.

Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Reddit r/Supplements, r/NMN, r/Nootropics — brand trust discussion

No affiliate relationship Not a paid placement

Mixed brand-trust discussion across Reddit. Some threads from 2022 allege aggressive affiliate marketing and deleted critical Facebook posts. A DoNotAge Partner Manager acknowledged a problematic ad from a former marketing agency. Senaste threads (2024-2026) increasingly recommend DoNotAge alongside Renue By Science as reputable NMN brands. No dedicated Reddit thread specifically reviewing the routine sachet was found.

How we use it: Community sentiment context for the brand, not the sachet specifically.

YouTube — sachet-specific review videos (9+ videos found)

Has affiliate relationship Not a paid placement

9+ YouTube videos specifically review the routine sachet. Nearly all are affiliate-monetized (referral/discount codes in descriptions). Coverage ranges from unboxing to one-month follow-up. Independent, non-monetized critical reviews of the sachet specifically were not found.

How we use it: Video review landscape is overwhelmingly affiliate-linked. Sentiment should be treated with caution.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Clinical study

positive

60-day company-funded trial on 15-ingredient sachet showed 76-79% NAD+ increase and 19% reduction in perceived fatigue. Tested as finished product, not individual ingredients.

Unverified · we received no payment for this listing

Independent comparison

positive

Ranked #1 longevity supplement stack by independent comparison site for formulation depth and clinical evidence. Noted as highest price at ~$203/month.

Unverified · we received no payment for this listing

Independent reviewer

positive

Longevity content creator reviewed entire product line, gave 4.5/5. Described brand as having good reputation for quality and trustworthiness, citing tested by independent lab ingredients with low heavy metal content.

Unverified · we received no payment for this listing

Vår sammanfattning

DoNotAge routine is a 15-in-1 daily sachet that dissolves in water and delivers approximately 9.6 g of active ingredients per portion at $7.25/day. It combines NAD+ precursors (NMN 1,000 mg, TMG 1,000 mg), sirtuin activators (SIRT6 Activator 1,600 mg, resveratrol 500 mg), mitochondrial support (CoQ10 200 mg), senolytic compounds (quercetin 400 mg, spermidine 8 mg), metabolic support (Ca-AKG 800 mg, glycine 2,000 mg), and proprietary additions (Nitralis, SulforaBoost, hyaluronic acid, D3, K2). The company conducted a 60-day dubbelblind placebokontrollerad trial on the finished product (n=28), reporting improved well-being and reduced fatigue, but the trial used subjective endpoints, was company-funded and company-authored, and has no peer-reviewed publication. Independent lab verification exists only for the standalone NMN ingredient (98% purity, no heavy metals), not for the sachet itself. The product is the most expensive all-in-one longevity stack on the market ($203/month vs NOVOS Core at $109, Blueprint at $49, AgeMate at $69-79), but uniquely discloses individual per-ingredient doses rather than using blends without listed amounts. Key concerns include the contested Nitralis trial, affiliate-heavy review ecosystem, and unverified NAD+ marketing claims.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 4Ingredient RCT (different dose)

3 studies mapped

Tier 4Ingredient RCT (different dose)

DoNotAge routine sachet — 60-day well-being and fatigue trial

DoNotAge.org staff (company-funded) · 2026 · Self-published on routine.donotage.org/science · n=28 · 1 sachet/day (full 15-ingredient formula) · 60 days

on this exact productnot peer-reviewed

WHO-5 well-being scores more than doubled; FACIT-Fatigue dropped 19%; 93% felt better or much better. Both primär endpoints significant at p < 0.0001.

The only known RCT testing the finished sachet product itself (not just individual ingredients). Strengths: dubbelblind, placebokontrollerad, multi-endpoint. Weaknesses: small n, subjective endpoints only, no peer-reviewed publication, company-funded and company-authored.

Conflicts: All study authors are DoNotAge employees. Trial was funded by DoNotAge. No independent ethics board approval documented.

Source →

Tier 4Ingredient RCT (different dose)

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino M, Yoshino J, Kayser BD, et al. · 2021 · Science · n=25 · 250 mg/day · 10 weeks

ingredient-levelpeer-reviewed

Modestly improved insulin sensitivity and muscle insulin signalling. Did not detect a measurable rise in blood NAD+.

The sachet delivers 1,000 mg NMN, 4x the dose in this landmark trial.

Conflicts: None identified; academic study (Washington University) with NIH funding.

Source →

Tier 4Ingredient RCT (different dose)

Nitralis nitric oxide pilot trial

DoNotAge.org staff (company-funded) · 2024 · Biomedical Tidskrift of Scientific & Technical Research (self-published via biomedres.us) · n=85 · Nitralis blend without listed amounts · 30 days

ingredient-levelnot peer-reviewed

Claims +226% increase in salivary nitrite. No blood NO, blood pressure, or vascular endpoint measured.

Omtvistad pilot study. The '226% increase' figure is widely repeated in marketing but refers to salivary nitrite, not a validated clinical outcome.

Conflicts: All authors are DoNotAge employees. Funded by DoNotAge. No independent ethics board approval. Criticized by Dr. Brad Stanfield for measuring salivary nitrite (not blood NO or clinical endpoints) and for delivering only ~60 mg actual nitrate (~15% of RCT doses showing vascular benefit).

Source →

Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support

“One supplement. Every hallmark of ageing. 15 powerful longevity ingredients in one easy-to-take sachet.”

The sachet does contain 15 ingredients, several of which have human trial data supporting specific health outcomes. However, 'every hallmark of ageing' is a marketing framing, not a tested claim — the company's own trial measured subjective well-being and fatigue, not aging hallmarks or biomarkers.

Unverified

“76% increase in NAD+ over 60 days”

The '76% NAD+ increase' figure is widely repeated in affiliate marketing content and YouTube videos but does not appear on DoNotAge's own science page, which instead reports WHO-5 well-being and FACIT-Fatigue outcomes. This claim could not be matched to any primär trial data and should be treated as a marketing/affiliate talking point pending direct confirmation.

Affiliate and YouTube sources repeating the figure; not found verbatim on the official science page.

Misleading

“+226% increase in nitric oxide (Nitralis ingredient)”

The study measured salivary nitrite, not blood nitric oxide or any vascular/clinical endpoint. All study authors are DoNotAge employees and the trial was company-funded with no independent ethics board approval. Dr. Brad Stanfield estimates Nitralis delivers only ~60 mg of actual nitrate, about 15% of doses used in RCTs that showed genuine vascular benefit.

Unverifiable

“$203 vs $683 individual ingredient cost — 70% discount”

The 'compare at' reference price fluctuated between $683 and $762 across different page states observed during research. The comparison price is not independently auditable and appears to be a marketing construct rather than a verified market basket.

Claim Only

“100% money-back guarantee”

Advertised prominently. Specific terms, time limits, and conditions were not independently verified.

NMN Betaine (TMG)CoQ10 SIRT6 Activator Spermidin

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

Legal as supplement

NMN was reinstated as lawful for supplement sale by the FDA on september 29, 2025, following a Natural Produkter Association citizen petition. The sachet contains multiple ingredients generally recognized as dietary supplement components.

Senast verifierad 2026-08-07

Novel Food, not cleared

NMN has not received EU Novel Food authorisation. The sachet's NMN content may face the same regulatory uncertainty as standalone NMN produkter in the EU market.

Senast verifierad 2026-08-07

Legal as supplement

DoNotAge is UK-based and operates under UK supplement regulations post-Brexit.

Senast verifierad 2026-08-07

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

Exact per-ingredient mg doses were not confirmed from an official DoNotAge supplement-facts label. The routine.donotage.org page renders its label via JavaScript/image, not extractable plaintext. All specific mg figures come from third-party review sites that claim to cite the official label.
Vitamin D3 and magnesium exact doses within the sachet were not confirmed by any source in this research pass.
No independent (non-DoNotAge-funded) lab testing or CoA of the finished sachet product was found. All third-party lab verification pertains to the standalone Pure NMN product, not the 15-in-1 sachet.
The '76% NAD+ increase' marketing claim could not be verified against the primär trial data. The company's own science page reports well-being and fatigue outcomes, not NAD+ levels.
The '$683 individual ingredient comparison price' is not independently auditable and fluctuated between $683 and $762 across page states.
No peer-reviewed publication of the sachet's 60-day clinical trial was found. The company offers 'the full paper' as a downloadable resource but the direct paper URL was not surfaced.
Most available sachet-specific YouTube and blog reviews are affiliate-monetized, which may bias sentiment. Independent non-affiliate critical reviews are more common for individual DoNotAge ingredients than for the sachet as a whole.

Important to know

NMNAbsorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.

Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination produkter) are well below the gram-level doses used in the supporting human trials.

CoQ10Cheap CoQ10 powder in capsules has minimal absorption. Look for softgels with oil carrier or ubiquinol form.

SIRT6 ActivatorFucoidan is inexpensive as a seaweed extract. High-priced 'SIRT6 activator' branding doesn't mean higher potency, check fucoidan mg/capsule.

SpermidinProduct labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.

Redaktionellt notes

DoNotAge's flagship 2026 all-in-one sachet combining 15 ingredients (NMN 1,000 mg, TMG 1,000 mg, Ca-AKG 800 mg, CoQ10 200 mg, SIRT6 Activator 1,600 mg, spermidine 8 mg, resveratrol 500 mg, quercetin 400 mg, Nitralis, glycine 2,000 mg, SulforaBoost, hyaluronic acid 200 mg, D3, K2 120 mcg, magnesium) at $7.25/day. Company ran a 60-day dubbelblind placebokontrollerad trial on the finished product (n=28) showing improved well-being and reduced fatigue, but with subjective endpoints, no peer-reviewed publication, and all authors are company employees. Independent lab verification exists only for standalone NMN (98% purity, no heavy metals), not the sachet itself. Most expensive all-in-one longevity stack on the market ($203/month vs NOVOS Core $109, Blueprint $49). Omtvistad Nitralis trial and unverified '76% NAD+ increase' marketing claim. Full dossier with 15-ingredient dose analysis, clinical trial breakdown, third-party lab results, Trustpilot sentiment, competitor comparison, and data gaps available on this page.

In plain language

Why this scored this way

The most ambitious all-in-one longevity stack we've scored: 15 ingredients at $7.25/day with a company-run 60-day RCT on the finished product. The score lands at 6.8 because the formulation drags it down hard: several ingredients (SIRT6 Activator, Nitralis) sit at evidence grade E with no independent human data, and the company's own trial used subjective well-being endpoints rather than aging biomarkers. Value and community scores are high, but transparency is capped at 8.0 because there is no public analysintyg for the sachet itself.

What drives the score up

15 ingredients in one daily sachet is the broadest longevity formulation on the market, covering NAD+ precursors, sirtuin activators, senolytics, and mitochondrial support in a single serving.
NMN is dosed at 1,000 mg, double the 500 mg trial dose and matching the top of the human trial range.
Spermidin at 8 mg exceeds most commercial doses and is well above the 1.2 mg used in human autophagy studies.
The company ran a dubbelblind placebokontrollerad trial on the finished sachet (n=28), not just individual ingredients, something almost no competitor has done.
Trustpilot ratings of 4.2-4.5/5 across 8 regional domains with 267-548 reviews each give a strong community score.
At $3.63 per dag at studied dose, the value score is high because the sachet delivers multiple research-level doses in one product.

What drags it down

SIRT6 Activator (1,600 mg) has evidence grade E: no independent human RCT exists. All supporting data comes from DoNotAge-funded animal research (Gorbunova lab).
Nitralis is backed by a company-funded, company-authored pilot trial that measured salivary nitrite, not blood nitric oxide or any clinical endpoint. Dr. Brad Stanfield estimates it delivers only ~60 mg actual nitrate, about 15% of RCT doses showing vascular benefit.
The 60-day sachet trial used subjective endpoints (WHO-5 well-being, FACIT-Fatigue) rather than objective aging biomarkers. All study authors are DoNotAge employees. No peer-reviewed publication was found.
No public analysintyg for the finished sachet. Independent lab verification exists only for standalone NMN capsules (98% purity), not the 15-in-1 product.
At $203/month it is the most expensive all-in-one longevity stack on the market: NOVOS Core costs $109, Blueprint $49, AgeMate $69-79.
The widely repeated '76% NAD+ increase' marketing claim could not be verified against the company's own trial data.
Nearly all sachet-specific YouTube reviews are affiliate-monetized, which may bias the community sentiment.

Why you'd choose it

You want one product that covers the broadest range of longevity pathways and cannot be bothered managing 15 separate bottles.
You value convenience over cost and are comfortable paying $203/month for a daily sachet.
You want a product where the finished formula itself was tested in a clinical trial, even if the trial was company-funded.
You specifically want SIRT6 Activator or Nitralis, which are proprietary to DoNotAge.

Why you might skip it

You care about evidence quality: several ingredients have no independent human data and the company trial used subjective endpoints.
You want a public analysintyg or third-party certification (NSF, USP) for the finished product.
You want the best value per dollar: NOVOS Core at $109/month or Blueprint at $49/month cover similar ground at a fraction of the cost.
You are uncomfortable with a product whose marketing claims (76% NAD+ increase, 226% nitric oxide) could not be verified against primär trial data.
You want to control individual ingredient doses: a sachet locks you into the manufacturer's ratio whether or not it matches your needs.

Go deeper

Where this sits

Actives inside

Kategori

Se alla in Multi/greens →

Varumärke

DoNotAge profile →

Jämför this product → Visit brand site →

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of DoNotAge® routine (15-in-1 Daily Sachet) and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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