Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.
This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.
The science behind each active ingredient, independent of which brand sells it.
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
The specific product: dose, price, transparency, and what buyers report.
Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.
All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.
Consumer signals gathered from 1 platform.
Low confidence, small sampleConsumer sentiment compiled from 1 public source (Reddit). Small sample size, treat as directional only.
1 threads discussed · positive sentiment
Compiled from a Reddit r/longevity listing located during manual research; not independently re-verified against the live page at build time.
These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.
We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.
These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.
Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.
Detailed ingredient walk-through. Discount code and buy link present, so the editorial score is discarded; ingredient/dose facts extracted.
Mood indicator only. We never use aggregate stars as evidence of efficacy.
Aggregate score ≈ 4.3-4.5 / 5. Mood indicator only.
Additional public mentions we located, kept separate from the deep independent reviews above.
Frequently paired with NMN/NR to offset methyl-donor depletion. DoNotAge is a common community pick.
Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.
No landmark studies linked yet. See the ingredient pages for the full evidence breakdown.
Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.
Rules change often. We record when we last verified each row. See the full regulatory timeline →
We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.
Companion to NAD+ boosters to offset methyl depletion.
This DoNotAge Pure TMG scores 6.5, making it a mid-tier product with both strengths and weaknesses. It delivers 2000mg of Betaine (TMG) (67% of the 3000mg trial dose) with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.5), with third-party testing and a public analysintyg. At $1.50/day it's among the more expensive options in Methyl donor.
If you are the manufacturer or brand owner of Pure TMG and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.
We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.
Request a correction →The next highest-scoring produkter in Methyl donor, same scoring method, same rules.