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TMG Supplement (Trimethylglycine)

Methyl donor · Capsule · 90 portioner#3 / 5 in Methyl donor
5.7
Overall score · out of 10
5.7
Overall score · out of 10
Dose vs. studies3.8
Transparency9.0
Value9.2
Community6.0
Formulation5.0
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
Redaktionellt score, paid $0 No affiliate link Tested by independent lab Public analysintyg Sample received: No
How we scored this product Show the full breakdown
Composite How this 5.7 is built. 0.55 × 3.8 + 0.20 × 9.0 + 0.10 × 9.2 + 0.10 × 6.0 + 0.05 × 5.0 = 5.7 out of 10. Säkerhet caps applied after. 5.7
5.7 composite
Dose vs. studies55%3.8
Transparency20%9.0
Value10%9.2
Community10%6.0
Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
33% av studiedosen
Well below the trial dose
Cost at trial dose
$0.66/day at trial dose
What one effective daily dose actually costs
Transparency
9.0/10 · Public analysintyg (quality: not assessed)
Independent batch testing confirmed
Consumer signals
169 reviews across platforms · 3.5/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Underdosed
Dose at 33% av studiedosen
Below 50% of the dose used in published clinical trials.
Buyer complaints
Trustpilot: Customer service and fulfillment complaints; Amazon: Some report no noticeable effect
Recurring themes from consumer review platforms.
Redaktionellt verdict

Quick verdict

5.7 / 10
Best for
Public analysintyg, Budget-friendly
Avoid if
Only 33% av studiedosen
Full-dose status
33% av studiedosen
Pris/month
$7
COA status
Public
Biggest caveat
Dose is 33% of the trial dose.
Nearest alternatives

The numbers

Pris
$20
per bottle · 90 portioner
Dose vs. research
Below trial dose 33%
of published effective dose
$ / day at studied dose
$0.66
what one effective daily dose costs
$ / g active
$0.22
per gram of active substance
Independently checked

Data verification

Pris
$20
Verified n/a
Dose
33% av studiedosen
Verified n/a
COA status
Public
Verified n/a
Bevisning grade
C
Per-ingredient breakdown
CBetaine (TMG)
Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Bevisning
Betaine (TMG)
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
1000.0 mg 33% av studiedosen
3000 mg
3.5 /5
High confidence
169 reviews across 4 platforms (4 sources)
Source diversity: 92%
AmazonRedditTrustpilotiHerb
PraiseEffective methylation support reported by someGood value for money
ComplaintsCustomer service and fulfillment complaintsSome report no noticeable effect
Last checked: 2026-08-07

Consumer signals

3.5 out of 5 across 169 verified reviews on 4 platforms.

Medium confidence

Consumer sentiment compiled from 4 public sources.

169 reviews · 3.5/5 · mixed sentiment

PraiseEffective methylation support reported by some
ComplaintsCustomer service and fulfillment complaints
ThemesDouble Wood's brand-wide Trustpilot rating remains average due to recurring service issues.

Compiled from Trustpilot listing located during research; verified at build time.

positive sentiment

PraiseGood value for moneyEffective for homocysteine/methylation support
ComplaintsSome report no noticeable effect
ThemesAmazon customers appreciate the value, quality, and effectiveness of this TMG supplement.

Compiled from Amazon listing located during research; verified at build time.

positive sentiment

PraiseWorks well alongside methylated multivitaminsReasonably dosed
ComplaintsNot confirmed as sold on iHerb
ThemesNot verified as available on iHerb; brand's related methylated multivitamin product gets positive customer feedback.

Compiled from iHerb listing located during research; verified at build time.

negative sentiment

PraiseSome find the produkter effective and well-priced
ComplaintsOrder/refund disputesTrust concerns about the brand generally
ThemesReddit sentiment toward Double Wood as a brand is notably negative due to service complaints, even though individual product reviews are often positive.

Compiled from Reddit listing located during research; verified at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Bevisning

Research behind this product

No landmark studies linked yet. See the ingredient pages for the full evidence breakdown.

Important to know
Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination produkter) are well below the gram-level doses used in the supporting human trials.

Redaktionellt notes

Frequently backordered/unavailable (was listed as backordered at time of check). Label serving (1000mg) is well below the 3000mg dose the vendor's own marketing cites for homocysteine reduction, would require 3x the recommended serving to hit the cited trial dose.

In plain language

Why this scored this way

This Double Wood Supplements TMG Supplement (Trimethylglycine) scores 5.7, making it below the site average. It contains 1000.0mg of Betaine (TMG), which is only 33% of the 3000mg trial dose with grade C evidence (mostly preclinical, limited human data). Transparency is a clear strength (score: 9.0), with third-party testing and a public analysintyg.

What drives the score up

  • Quality transparency of 9.0: tested by independent lab with a public analysintyg.

What drags it down

  • Dose-evidence score of 3.8 is below average for the site.
  • Overall dose is only 33% of the trial dose across ingredients.
  • Betaine (TMG) (1000.0mg is 33% of the 3000mg trial dose) is significantly under-dosed.
  • Limited consumer feedback (community score: 6.0).

Why you'd choose it

  • You want good value at $0.66/day.
  • You prioritise tested by independent lab produkter with public lab certificates.

Why you might skip it

  • You need a full trial dose of betaine (this product under-doses it).
  • You want a product that hits the full trial dose (this is at 33%).
  • You want a higher-scoring product (this scores 5.7).
Go deeper

Where this sits

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of TMG Supplement (Trimethylglycine) and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

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