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Senolytic Activator

Autophagy · Capsule · 12 portioner#17 / 22 in Autophagy
5.5
Overall score · out of 10
5.5
Overall score · out of 10
Dose vs. studies4.3
Transparency8.0
Value6.3
Community6.0
Formulation5.0
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
Redaktionellt score, paid $0 No affiliate link Tested by independent lab No public analysintyg Sample received: No
How we scored this product Show the full breakdown
Composite How this 5.5 is built. 0.55 × 4.3 + 0.20 × 8.0 + 0.10 × 6.3 + 0.10 × 6.0 + 0.05 × 5.0 = 5.5 out of 10. Säkerhet caps applied after. 5.5
5.5 composite
Dose vs. studies55%4.3
Transparency20%8.0
Value10%6.3
Community10%6.0
Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Highly-hyped senolytic; the strong evidence is in mice, not people.

3 landmark RCTs · US: Dietary supplement · EU: Food supplement

A lecithin-bound quercetin form built to fix quercetin's biggest problem: almost none of a standard dose reaches the blood.

1 landmark RCT · US: Dietary supplement · EU: Food supplement

A plant flavonoid that may slow the age-related NAD+ drain by inhibiting the CD38 enzyme.

2 landmark RCTs · US: Dietary supplement, no NDI restriction · EU: Food supplement, permitted (novel food status product-specific)
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
62% av studiedosen
Below the full trial dose
Cost at trial dose
$2.66/day at trial dose
What one effective daily dose actually costs
Transparency
8.0/10 · No public analysintyg
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Säkerhet signals
Drug interaction risk — fisetin
maj potentiate warfarin via competition for glucuronidation; theoretical mild antiplatelet activity warrants caution with anticoagulants and chemotherapy agents.
Läs mer
No public analysintyg
Certificate of Analysis not published
Without a public analysintyg, batch purity and potency cannot be independently verified.
Redaktionellt verdict

Quick verdict

5.5 / 10
Best for
Basic coverage
Avoid if
Only 62% av studiedosen, No public analysintyg
Full-dose status
62% av studiedosen
Pris/month
$50
COA status
Not public
Biggest caveat
Dose is 62% of the trial dose.
Nearest alternatives

The numbers

Pris
$20
per bottle · 12 portioner
Dose vs. research
Below trial dose 62%
of published effective dose
$ / day at studied dose
$2.66
what one effective daily dose costs
$ / g active
$4.28
per gram of active substance
Independently checked

Data verification

Pris
$20
Verified n/a
Dose
62% av studiedosen
Verified n/a
COA status
Not public
Verified n/a
Bevisning grade
CBD
Per-ingredient breakdown
CFisetin
BQuercetin Phytosome
DApigenin
Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Bevisning
312.0 mg 62% av studiedosen
500 mg
Quercetin Phytosome
A lecithin-bound quercetin form built to fix quercetin's biggest problem: almost none of a standard dose reaches the blood.
25.0 mg 10% av studiedosen
250 mg
Apigenin
A plant flavonoid that may slow the age-related NAD+ drain by inhibiting the CD38 enzyme.
50.0 mg 100% av studiedosen
50 mg
3.9 /5
Medium confidence
Rated on 2 platforms (2 sources, no structured review counts)
Source diversity: 46%
TrustpilotiHerb
Praisehigh-quality bioavailable formula (fisetin, quercetin)convenient weekly dosing
Last checked: 2026-08-07

Consumer signals

Consumer signals gathered from 2 platforms.

Medium confidence

5.0/5 · positive sentiment

Praisehigh-quality bioavailable formula (fisetin, quercetin)convenient weekly dosingaffordable and long-lasting
ThemesiHerb reviewers rate the Senolytic Activator highly, citing bioavailable ingredients, convenient weekly dosing, and increased energy/revitalization.

Compiled from a iHerb product reviews listing located during research; verified at build time.

positive sentiment

Praisehigh quality and purity, free of unnecessary fillersreasonable prices with sales
ThemesLife Extension's broader Trustpilot reviews highlight purity, absence of unnecessary fillers, and value during sales, applicable across its senolytic product line.

Compiled from a Trustpilot listing located during research; verified at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Important to know
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.
Quercetin PhytosomeThe 20-fold bioavailability data is specific to the branded phytosome form studied by Riva et al.; it should not be assumed for other enhanced quercetin blends without their own pharmacokinetic data. No head-to-head trial yet compares clinical outcomes (not just blood levels) between phytosome and standard quercetin.
ApigeninBioavailability is low without a fat carrier or phytosome form; grapefruit-derived apigenin retains CYP3A4 interaction risk.

Redaktionellt notes

LEF's dedicated senolytic stack, fisetin (56mg actual, via a 'Bio-Fisetin' bioavailability-enhanced blend) plus theaflavins, quercetin phytosome, and apigenin, dosed weekly rather than daily; the weekly-not-daily dosing echoes the intermittent 'hit' protocol used in senolytic research (e.g., fisetin/dasatinib trials), but the actual fisetin dose here (56mg/week) is far below the ~20mg/kg human-equivalent doses tested in senolytic fisetin trials.

In plain language

Why this scored this way

This Life Extension Senolytic Activator scores 5.5, making it below the site average. It contains 25.0mg of Quercetin Phytosome, which is only 10% of the 250mg trial dose with grade B evidence (promising human data, not yet comprehensive). At $2.66/day it's among the more expensive options in Autophagy.

What drives the score up

  • Tested by independent lab (transparency 8.0).

What drags it down

  • Dose-evidence score of 4.3 is below average for the site.
  • Quercetin Phytosome (25.0mg is 10% of the 250mg trial dose) is significantly under-dosed.
  • No public analysintyg available for independent verification.
  • Limited consumer feedback (community score: 6.0).
  • At $2.66/day it's on the expensive side.

Why you'd choose it

  • You want Quercetin Phytosome from a Life Extension product.
  • You want a tested by independent lab product.

Why you might skip it

  • You want a product with a publicly available CoA.
  • You need a full trial dose of quercetin phytosome (this product under-doses it).
  • You want a cheaper option (this is $2.66/day).
Go deeper

Where this sits

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Senolytic Activator and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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