NMN Pro 1000

Yi et al. 2023 (GeroScience)Okabe et al. 2022 (Frontiers in Nutrition)Uthever RCT 2022

NMN Pro 1000

Name: NMN Pro 1000
Brand: ProHealth Longevity
SKU: prohealth-nmn-pro
Price: 79.0 USD
Availability: InStock
Rating: 4.7 (800 reviews)

NAD+ booster · Capsule · 30 portioner#12 / 46 in NAD+ booster

7.1

Overall score · out of 10

7.1

Overall score · out of 10

Dose vs. studies6.1

Transparency9.0

Value8.3

Community9.0

Formulation5.0

Tier 4

Ingredient RCT (different dose)

The ingredient was tested in an RCT but at a different dose, or only in animals.

Redaktionellt score, paid $0 No affiliate link Tested by independent lab Public analysintyg Sample received: No

How we scored this product Show the full breakdown

Dose vs. studies (55%) 6.1

Transparency (20%) 9.0

Value (10%) 8.3

Community sentiment (10%) 9.0

Formulation (5%) 5.0

Composite 7.1

7.1 composite

Dose vs. studies55%6.1

Transparency20%9.0

Value10%8.3

Community10%9.0

Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

NMN Grade B

A NAD+ building block that has become the most-hyped longevity molecule.

5 landmark RCTs · US: FDA NDI status volatile (juli 2026) · EU: Unauthorised Novel Food (EFSA positive maj 2026, no Commission listing yet)

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

200% av studiedosen

Meets or exceeds the published effective dose

Cost at trial dose

$1.32/day at trial dose

What one effective daily dose actually costs

Transparency

9.0/10 · Public analysintyg (quality: not assessed)

Independent batch testing confirmed

Consumer signals

800 reviews across platforms · 4.7/5 · high confidence

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No major red flags

Public analysintyg, tested by independent lab, dose within range

No safety, transparency, or dose concerns detected at this time.

Best for

Full trial dose, Public analysintyg

Avoid if

No major red flags

Full-dose status

Meets trial dose

Pris/month

$79

COA status

Public

Biggest caveat

No significant caveats at this time.

Nearest alternatives

NMN Pure Powder (Sublingual) Renue By Science · Poäng 8.4
Pure NMN Capsules Partiqlar · Poäng 7.8
NOVOS Boost NOVOS Labs · Poäng 7.4

The numbers

Pris

$79

per bottle · 30 portioner

Dose vs. research

Above trial dose 200%

of published effective dose

$ / day at studied dose

$1.32

what one effective daily dose costs

$ / g active

$2.63

per gram of active substance

Independently checked

Data verification

Pris

$79

Verified n/a

Dose

200% av studiedosen

Verified n/a

COA status

Public

Verified n/a

Bevisning grade

Per-ingredient breakdown

BNMN

Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Bevisning

NMN

A NAD+ building block that has become the most-hyped longevity molecule.

1000 mg 200% av studiedosen

500 mg

4.7 /5

Medium confidence Strong value signal

800 reviews across 2 platforms (2 sources)

Source diversity: 46%

RedditTrustpilot

PraiseUthever® partnership + published CoAs give it high trust in the community.4.7/5 across ~800 reviews. Highest-rated NMN on Trustpilot.

Last checked: 2026-08-07

Consumer signals

4.7 out of 5 across 800 verified reviews on 2 platforms.

High confidence

Consumer sentiment compiled from 2 public sources (Reddit, Trustpilot).

1 threads discussed · positive sentiment

PraiseUthever® partnership + published CoAs give it high trust in the community.

Compiled from a Reddit r/longevity listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

800 reviews · 4.7/5 · positive sentiment

Praise4.7/5 across ~800 reviews. Highest-rated NMN on Trustpilot.

Compiled from a Trustpilot listing located during manual research; not independently re-verified against the live page at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Healthline

No affiliate relationship Not a paid placement

Healthline's 2026 buyer's guide omits ProHealth Longevity entirely from its recommended list.

Finding: ProHealth Longevity does not appear among Healthline's current top picks (best overall: California Gold Nutrition; best quality/transparency: Double Wood; best value: Nutricost).

How we use it: Used as a neutral, non-affiliate data point noting the product's absence from a reputable comparison guide; not itself a negative or positive review of ProHealth specifically.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Innerbody

Has affiliate relationship Not a paid placement

Innerbody includes ProHealth in its comparison set but ranks a competing combination product higher overall; treats ProHealth as a credible, higher-priced single-ingredient option.

Finding: Lists ProHealth NMN Pro 1000mg at $115 ($3.83/g); does not select ProHealth as its top overall pick (a different 700mg NMN+NR+BioPerine combination product is named 'best overall').

How we use it: Used as a secondary, disclosed-affiliate comparison point on pricing and category positioning; not used as an endorsement, since Innerbody does not name ProHealth as a top pick and carries an active affiliate discount code (INNERBODY10) for it.

Independent NMN purity testing (22 consumer produkter, okt 2021)

No affiliate relationship Not a paid placement

An independent lab test found ProHealth's product accurately labeled, in contrast to most competitors tested.

Finding: ProHealth Longevity NMN Pro 300 tested at 301mg vs. a 300mg label claim (100.3%); one of only three of 21-22 brands tested that contained their labeled NMN amount, while 14 brands reportedly contained less than 1% of the claimed amount.

How we use it: Used as supporting evidence for label accuracy, but flagged with a lower tier because this specific summary of the underlying report is republished on ProHealth's own site rather than sourced directly from the original testing organization's report, whose exact identity/sponsor was not fully confirmed.

Trustpilot (www.prohealth.com)

No affiliate relationship Not a paid placement

A small-sample, below-average rating on the company's main Trustpilot page; a separate ca.trustpilot.com listing for the same domain shows a larger but still modest sample (~62-71 reviews) with a more positive sentiment summary (customers describing 'high-quality, effective' produkter and 'scientific backing and third-party testing') alongside recurring complaints about customer-service responsiveness and delivery delays.

Finding: 2.5/5 average rating, N=25 reviews on the primär prohealth.com Trustpilot listing.

How we use it: Reported as the primär Trustpilot data point given it is the main company domain, with the sample size (N=25, well below the N>500 threshold for a reliable independent sample) explicitly flagged as a caveat; the ProHealth-hosted on-site review widget (8,345 reviews, 88% 5-star) is not used as independent evidence since it is vendor-controlled.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Reddit r/longevity

positive

Uthever® partnership + published CoAs give it high trust in the community.

Read source → Unverified · we received no payment for this listing

Trustpilot · 4.7

positive

4.7/5 across ~800 reviews. Highest-rated NMN on Trustpilot.

Read source → Unverified · we received no payment for this listing

Vår sammanfattning

ProHealth Longevity's NMN Pro 1000 delivers 1000 mg of Uthever-brand NMN per portion, four times the 250 mg dose used in the most-cited academic human trials (Yoshino et al. 2021, Igarashi et al. 2022, Morifuji et al. 2024), and roughly matches the top of the Effepharm-sponsored dose-ranging range (up to 900 mg) but has not itself been tested in a peer-reviewed trial at exactly 1000 mg or as this finished capsule. The strongest ingredient-level evidence comes from Effepharm's own Uthever trials (Huang et al. 2022; Yi et al. 2022), which show real NAD+ and quality-of-life improvements at lower doses but carry a manufacturer conflict of interest, placing this product at Tier 4 (ingredient RCT, different dose). A prior independent purity test found ProHealth's labeled NMN content accurate, a genuine positive signal in a category where many competing produkter have failed similar tests, but buyers should treat the vendor's 'decreased biological age by 12 years' and '100x absorption' marketing claims with real skepticism, as neither is fully supported by the cited science once examined closely.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 4Ingredient RCT (different dose)

6 studies mapped

Tier 4Ingredient RCT (different dose)

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino M, Yoshino J, Kayser BD, et al. · 2021 · Science · n=25 · 250 mg/day · 10 weeks

ingredient-levelpeer-reviewed

Muscle insulin sensitivity improved (~25% increase in insulin-stimulated glucose disposal); no improvement in hepatic insulin sensitivity, body composition, or blood lipids.

Flagship human NMN RCT, but at 250 mg/day — one quarter of ProHealth's 1000 mg dose — and in a narrow population (prediabetic postmenopausal women) not representative of the general longevity-supplement buyer. A published critique (Science.org, DOI 10.1126/science.abj1696) flags a baseline hepatic-lipid imbalance between groups as a randomization concern. Ingredient RCT at a different dose than the ProHealth product — Tier 4.

Conflicts: None identified; NIH-funded academic trial (Washington University)

Tier 4Ingredient RCT (different dose)

Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. · 2022 · npj Aging · n=42 · 250 mg/day · 6 or 12 weeks

ingredient-levelpeer-reviewed

Significant increases in blood NAD+ and related metabolites; nominally significant improvements in gait speed and left-hand grip strength; no significant change in body composition.

Senior author Toshimasa Yamauchi (University of Tokyo) — this is the likely source of the task brief's 'Yamauchi' reference, though it predates and differs from the 2024 Morifuji sleep/gait trial. Dose (250 mg) is a quarter of ProHealth's 1000 mg claim, and the trial had meaningful attrition. Ingredient RCT at a different dose — Tier 4.

Conflicts: None identified; academic trial (University of Tokyo)

Tier 4Ingredient RCT (different dose)

Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a dubbelblind randomized, placebokontrollerad study

Morifuji M, et al. · 2024 · GeroScience · n=60 · 250 mg/day · 12 weeks

ingredient-levelpeer-reviewed

NMN group showed significantly shorter 4-meter walking time vs. placebo at 12 weeks and improved sleep-quality sub-scores (PSQI daytime dysfunction and global score) vs. placebo.

This is the study most likely intended by the task brief's 'Yamauchi 2024 sleep/gait trial' reference, though the lead author is Morifuji, not Yamauchi; sponsored/announced by Meiji Holdings (https://www.meiji.com/global/news/2024/pdf/240621_01.pdf). Dose (250 mg) is a quarter of ProHealth's 1000 mg product. Ingredient RCT at a different dose — Tier 4.

Conflicts: Sponsored/announced by Meiji Holdings (a NMN/NAD ingredient and consumer-goods company)

Tier 4Ingredient RCT (different dose)

Säkerhet and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and NAD biosynthesis in healthy, middle-aged Japanese men

Yamaguchi S, Irie J, et al. · 2024 · Endocrine Tidskrift · n=11 · 125 mg twice daily (250 mg/day total) · 8 weeks

ingredient-levelpeer-reviewed

Increased NAD+ in peripheral blood mononuclear cells; modest attenuation of postprandial hyperinsulinemia in the subset who were insulin-oversecretors (n=3); no significant change in sleep quality reported (contrasts with the Morifuji 2024 finding).

Single-arm, open-label design (not placebokontrollerad), very small sample (n=11). Included for completeness as a second 2024 Japanese NMN trial that could be confused with the task brief's 'Yamauchi 2024' reference. Dose again a quarter of ProHealth's claim. Ingredient RCT at a different dose, weak design — Tier 4.

Conflicts: None identified

Tier 4Ingredient RCT (different dose)

Uthever (NMN Supplement): Evaluation of its Säkerhet and Efficacy in an in vivo Model and Human Clinical Trial

Huang H, et al. (Effepharm-affiliated author) · 2022 · Frontiers in Aging · n=66 · 300 mg/day (2 x 150 mg) · 60 days

ingredient-levelpeer-reviewed

NAD+/NADH ratio increased 11.3% by day 30 and 38% by day 60 vs. a 14.3% placebo change; SF-36 quality-of-life score improved 6.5% vs. 3.4% for placebo; HOMA-IR (insulin resistance) remained stable in the NMN group vs. a 30.6% rise in placebo.

This is the single most relevant trial: it is run on the same Uthever raw ingredient ProHealth uses (same manufacturer, Effepharm), but at 300 mg/day — less than one-third of ProHealth's 1000 mg finished-product dose — and not on ProHealth's own capsule. The corresponding author is Effepharm-affiliated, a direct conflict of interest, and this specific 'decreased biological age by 12 years' figure that ProHealth's own marketing attributes to this paper could NOT be independently confirmed in the retrieved abstract/summary of this trial — see claim_check. Ingredient RCT, dose mismatch, company-authored — Tier 4.

Conflicts: Corresponding author affiliated with Effepharm, the manufacturer of the Uthever NMN ingredient tested

Tier 4Ingredient RCT (different dose)

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, dubbelblind, placebokontrollerad, parallellgrupp, dose-dependent clinical trial

Yi L, Maier AB, Tao R, et al. · 2022 · GeroScience · n=80 · 300, 600, or 900 mg/day (dose-ranging vs. placebo) · 60 days

ingredient-levelpeer-reviewed

NAD+ levels and physical performance (6-minute walk test) improved dose-dependently, with effects appearing to plateau around 600 mg/day; no safety signal at doses up to 900 mg/day.

This is the closest dose-matched evidence available for ProHealth's 1000 mg product — the 900 mg arm approaches but does not reach the labeled 1000 mg dose, and the trial is again Effepharm-sponsored (same manufacturer as Uthever). No arm tested exactly 1000 mg. Ingredient RCT, close-but-not-matching dose, sponsor conflict — Tier 4.

Conflicts: Effepharm-sponsored dose-ranging trial of its own Uthever NMN ingredient

NMN Yi et al. 2023 (GeroScience)

Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

NMN Okabe et al. 2022 (Frontiers in Nutrition)

NMN Uthever RCT 2022

NMN NMN metaanalys 2024 (12 RCTs)

NMN Zhang et al. 2026 metaanalys (Nutrients)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support

“"NMN Pro 1000 capsules provide maximum absorption by focusing delivery into the small intestine's Slc12a8 NMN transporter sites, where NMN absorption is increased over 100 times."”

The underlying science is real but the claim stretches it: Grozio et al. 2019 (Nature Metabolism, https://doi.org/10.1038/s42255-018-0009-4) found the Slc12a8 gene is expressed roughly 100-fold higher in mouse small intestine than in other tissues — a tissue-expression comparison in mice, not a demonstration that ProHealth's specific capsule formulation increases a person's NMN absorption 100x relative to a competitor's product. A 2025 Science Advances paper (Kobayashi et al., https://www.science.org/doi/10.1126/sciadv.adr1538) further found that only a small portion of orally administered NMN or NR is directly absorbed intact from the small intestine, with most first converted to nicotinamide — suggesting the absorption mechanism ProHealth's marketing leans on is still scientifically contested.

Vendor source

Partial support

“"In a published peer reviewed, double blind, placebo controlled clinical trial, 60 days of ProHealth Longevity Uthever NMN: Decreased Biological Age by 12 years; Boosted NAD+ by 38%; Improved quality-of-life measurements by 6.5%."”

The 38% NAD+ increase and 6.5% quality-of-life improvement figures are corroborated by the cited trial (Huang et al. 2022, Frontiers in Aging, https://doi.org/10.3389/fragi.2022.851698). However, that trial used a 300 mg/day dose — less than one-third of the 1000 mg ProHealth actually sells in this product — was run in Pune, India (not on US consumers), and its corresponding author is affiliated with Effepharm, the ingredient manufacturer, a clear conflict of interest. The specific 'decreased biological age by 12 years' figure could not be confirmed in the retrieved summary of this paper; it may be conflated with a different Effepharm-sponsored trial on a separate NMNH product line, which reports a distinct biological-age claim. Buyers should not read this as proof that the exact 1000 mg capsule they are buying was clinically shown to reverse 12 years of aging.

Vendor source

Partial support

“"Every batch of ProHealth Uthever® NMN sold is tested by independent lab in an independent U.S. lab... Certificates of Analysis available on our website."”

A genuine third-party CoA from Micro Quality Labs Inc. (A2LA-accredited) was located for a Uthever NMN batch showing 99.70% purity and heavy metals well within limits. This supports third-party testing occurring at the ingredient level. However, this research pass could not locate a CoA specifically tied to the finished 1000 mg NMN Pro capsule SKU (batch-specific, dated, and matched to the exact product a buyer receives), so full batch-to-bottle traceability for this specific product could not be independently confirmed.

Vendor source

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

No CoA specific to the finished 1000 mg NMN Pro capsule SKU (as opposed to the raw Uthever ingredient generally, or other ProHealth pack sizes) was located in this research pass.
The specific 'decreased biological age by 12 years' marketing claim, attributed to the Huang et al. 2022 Frontiers in Aging trial, could not be confirmed in the retrieved paper abstract/summary and may be misattributed from a different Effepharm-sponsored trial on a separate product line.
Current CEO of ProHealth Longevity could not be reconfirmed; a 2021 trade-press article names Nancy Dayton as CEO, while founder Rich Carson's LinkedIn suggests a Founder/Chairman role since late 2017 rather than day-to-day CEO.
ConsumerLab's dedicated ProHealth page (https://www.consumerlab.com/prohealth/) could not be fetched in this pass (timeout); it is unconfirmed whether ConsumerLab has independently tested this specific product.
Trustpilot data is inconsistent across regional/domain listings (2.5/5 with N=25 on the main .com domain vs. more positive but similarly small samples on other regional Trustpilot pages) and none reach the N>500 threshold the source-hierarchy guidance treats as a reliable independent sample size.
EU sale/novel-food status for NMN, and whether ProHealth ships this product to EU customers under current rules, was not independently confirmed.

Important to know

NMNAbsorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.

Redaktionellt notes

Uthever® branded NMN with published CoAs.

In plain language

Why this scored this way

This ProHealth Longevity NMN Pro 1000 scores 7.1, making it a mid-tier product with both strengths and weaknesses. It delivers the full 1000mg trial dose of NMN with grade B evidence (promising human data, not yet comprehensive). Transparency is a clear strength (score: 9.0), with third-party testing and a public analysintyg.

What drives the score up

Dose-evidence score of 6.1 shows decent alignment with trial doses.
Quality transparency of 9.0: tested by independent lab with a public analysintyg.
Community score of 9.0 with positive consumer feedback.
NMN is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

NMN (1000mg is 200% of the 500mg trial dose) is well above the trial dose. More is not always better.

Why you'd choose it

You want a reasonably priced nad+ booster product.
You want NMN from a ProHealth Longevity product.
You prioritise tested by independent lab produkter with public lab certificates.

Why you might skip it

You want a standard dose of nmn (this product is well above it).
You want better value (this is $1.32/day with a value score of 8.3).

Go deeper

Where this sits

Actives inside

NMN

Kategori

Se alla in NAD+ booster →

Varumärke

ProHealth Longevity profile →

Jämför this product → Visit brand site →

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of NMN Pro 1000 and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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