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Alpha Lipoic Acid 400 mg

Antioxidant · Capsule · 120 portioner#5 / 25 in Antioxidant
7.0
Overall score · out of 10
7.0
Overall score · out of 10
Dose vs. studies7.9
Transparency5.0
Value8.4
Community6.0
Formulation5.0
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
Redaktionellt score, paid $0 No affiliate link No third-party test No public analysintyg Sample received: No
How we scored this product Show the full breakdown
Composite How this 7.0 is built. 0.55 × 7.9 + 0.20 × 5.0 + 0.10 × 8.4 + 0.10 × 6.0 + 0.05 × 5.0 = 7.0 out of 10. Säkerhet caps applied after. 7.0
7.0 composite
Dose vs. studies55%7.9
Transparency20%5.0
Value10%8.4
Community10%6.0
Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Mitochondrial cofactor with genuine efficacy in diabetic neuropathy.

4 landmark RCTs · US: Dietary supplement · EU: Restricted in Italy/EU (safety review); food supplement elsewhere
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
67% av studiedosen
Below the full trial dose
Cost at trial dose
$1.21/day at trial dose
What one effective daily dose actually costs
Transparency
5.0/10 · No public analysintyg
No third-party testing disclosed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No public analysintyg
Certificate of Analysis not published
Without a public analysintyg, batch purity and potency cannot be independently verified.
No third-party testing
Independent lab verification not disclosed
The brand does not publish evidence of independent batch testing.
Buyer complaints
Trustpilot: brand-level score is low, not product-specific; Amazon: yellow or strong-smelling urine
Recurring themes from consumer review platforms.
Redaktionellt verdict

Quick verdict

7.0 / 10
Best for
Budget-friendly
Avoid if
Only 67% av studiedosen, No public analysintyg
Full-dose status
67% av studiedosen
Pris/month
$24
COA status
Not public
Biggest caveat
Dose is 67% of the trial dose.
Nearest alternatives

The numbers

Pris
$97
per bottle · 120 portioner
Dose vs. research
Below trial dose 67%
of published effective dose
$ / day at studied dose
$1.21
what one effective daily dose costs
$ / g active
$2.02
per gram of active substance
Independently checked

Data verification

Pris
$97
Verified n/a
Dose
67% av studiedosen
Verified n/a
COA status
Not public
Verified n/a
Bevisning grade
A
Per-ingredient breakdown
AAlpha-Lipoic Acid
Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Bevisning
400.0 mg 67% av studiedosen
600 mg
2.7 /5
Medium confidence
8 reviews across 4 platforms (4 sources)
Source diversity: 92%
AmazonRedditTrustpilotiHerb
Praisetrusted supplement brandboosted energy and mental clarity
Complaintsbrand-level score is low, not product-specificyellow or strong-smelling urine
Last checked: 2026-08-07

Consumer signals

Consumer signals gathered from 5 platforms.

Low confidence, small sample

Consumer sentiment compiled from 4 public sources; most Trustpilot data reflects brand-level rather than product-specific feedback.

8 reviews · 2.4/5 · mixed sentiment

Praisetrusted supplement brand
Complaintsbrand-level score is low, not product-specific
ThemesTrustpilot score reflects the brand overall, not this specific product; scores skew low despite product-level praise elsewhere.

Compiled from Trustpilot listing located during research; verified at build time.

positive sentiment

Praiseboosted energy and mental claritystrong antioxidant support
Complaintsyellow or strong-smelling urine
ThemesBuyers report better energy and clarity, with mild urine odor as the main complaint.

Compiled from Amazon listing located during research; verified at build time.

positive sentiment

Praiserelief from nerve/neuropathy paineasy to swallow
ThemesiHerb reviewers highlight relief from nerve pain and fast, reliable delivery.

Compiled from iHerb listing located during research; verified at build time.

2 threads discussed · mixed sentiment

Praisereported relief from neuropathy symptoms
Complaintseffectiveness debated for some users
ThemesReddit threads on ALA for neuropathy show some users reporting relief, though effectiveness is debated generally for the ingredient.

Compiled from Reddit listing located during research; verified at build time.

1 threads discussed · positive sentiment

Themesused specifically for nerve-pain symptom relief rather than general antioxidant supportanecdotal improvement reported over a period of weeks, not immediate

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site
SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

NIH DSLD registered label
DSLD ID 219092, UPC 7 66298 00473 0
Portionstorlek1-2 Capsule(s)
Portioner per container120
Supplement Facts panel, verbatim
Alpha Lipoic Acid400 mg
Ascorbyl Palmitate16 mg

What others say (unverified)

No external reviews aggregated yet for this product.

Vår sammanfattning

Pure Encapsulations' Alpha Lipoic Acid 400 mg is a high-purity, single-ingredient synthetic ALA capsule with a wide self-directed dosing range (400-1,600 mg/day) but no third-party testing or public COA for this SKU. The strongest positive clinical evidence for ALA in diabetic neuropathy (the ALADIN trial) used intravenous dosing that does not directly transfer to this oral product, while the more applicable oral-ALA meta-analyses support doses of 600-1,800 mg/day, meaning a buyer taking just one capsule daily is likely under-dosed relative to the studied range. This is a reasonable ingredient choice for people already advised to try ALA, but the label's broad dosing latitude puts the burden on the buyer to land in the actually-studied range.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 4Ingredient RCT (different dose)
2 studies mapped
Tier 0No source
The Effect of Intravenous Alpha-Lipoic Acid on Peripheral Nerve Function in Diabetic Patients (ALADIN Studie)
Ziegler D, Hanefeld M, Ruhnau KJ, et al. · 1995 · Diabetologia · IV alpha-lipoic acid 600 mg/day · 3 weeks
ingredient-levelpeer-reviewed
Reduced diabetic neuropathy symptom score by 63.5% versus 38.4% with placebo (p<0.001).
This is the landmark positive ALA neuropathy trial frequently cited by supplement marketing, but the route of administration is intravenous, not oral. Pure Encapsulations' product is an oral capsule; oral ALA has substantially lower and more variable bioavailability than IV dosing, so this trial's result cannot be assumed to transfer directly to an oral 400 mg capsule.
Conflicts: Not disclosed in the available citation; industry funding for ALADIN-series trials (originally studied a branded IV ALA drug in Germany) is plausible but not confirmed here
Tier 4Ingredient RCT (different dose)
Efficacy and safety of oral alpha-lipoic acid for diabetic peripheral neuropathy: a systematisk översikt and metaanalys
Multiple (metaanalys of oral ALA RCTs) · 2025 · Peer-reviewed diabetes/endocrinology journal (2024/2025 metaanalys) · n=1345 · 600-1,800 mg/day oral · Varies by included trial, generally weeks to months
ingredient-levelpeer-reviewed
Reported significant improvements in HbA1c, neuropathy impairment score, total symptom score, neuropathy disability score, and vibration perception threshold across the pooled oral trials.
This metaanalys of ORAL (not IV) ALA trials used doses of 600-1,800 mg/day, which requires 2-4+ capsules/day of this 400 mg product; a single capsule (400 mg) is below this studied range. An earlier, smaller systematisk översikt of 8 oral RCTs (1,500 patients) found only 3 of 8 trials showed significant improvement, so the oral evidence base, while more applicable to this product's route of administration, is more mixed than the IV literature.
Conflicts: Not identified in available summary
Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support
“Supports healthy glucose metabolism and antioxidant status”
Oral ALA meta-analyses do show glucose-related improvements (HbA1c, neuropathy markers) at 600-1,800 mg/day (https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/), a range this product reaches only at 2+ capsules/day, not the single-capsule dose. The landmark ALADIN trial often invoked for ALA's neuropathy benefits used intravenous dosing (https://pubmed.ncbi.nlm.nih.gov/8786016/), which is not comparable to this oral capsule's expected bioavailability, a route-of-administration gap the vendor page does not address.

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • No public Certificate of Analysis or independent third-party lab test was found for this specific SKU.
  • No RCT was located using this exact oral 400 mg capsule as the study material.
  • The vendor's suggested-use range (1-4 capsules/day) spans a fourfold dose difference, and the label does not specify which dose within that range is supported by which cited outcome.
  • The strongest positive neuropathy trial (ALADIN) used intravenous administration; oral bioavailability of ALA is known to be lower and more variable, so this trial should not be read as direct evidence for this oral product.
Important to know
Alpha-Lipoic AcidCheap 'ALA' produkter sell the racemic form (50% inactive). Look for 'R-ALA' or 'R-alpha-lipoic acid'. Take on empty stomach.

Redaktionellt notes

A single-ingredient 400mg ALA capsule at the pricier end (~$0.81-1.62/day) versus the brand's own 100/200/600mg tiers, mid-range dose within ALA's typical 100-1200mg/day research range for glucose/nerve support.

In plain language

Why this scored this way

This Pure Encapsulations Alpha Lipoic Acid 400 mg scores 7.0, making it a mid-tier product with both strengths and weaknesses. It delivers 400.0mg of Alpha-Lipoic Acid (67% of the 600mg trial dose) with grade A evidence (strong human trial data). The quality transparency (5.0) is limited by the lack of third-party testing.

What drives the score up

  • Dose-evidence score of 7.9 shows decent alignment with trial doses.
  • Alpha-Lipoic Acid has grade A evidence and is dosed at 67% of the trial dose.

What drags it down

  • No third-party testing, which caps the quality transparency.
  • Quality transparency of 5.0 is below the site average.
  • Limited consumer feedback (community score: 6.0).

Why you'd choose it

  • You want a reasonably priced antioxidant product.
  • You want Alpha-Lipoic Acid from a Pure Encapsulations product.
  • You want doses that align with published research.

Why you might skip it

  • You want third-party verified purity.
  • You want a product with a publicly available CoA.
  • You want better value (this is $1.21/day with a value score of 8.4).
Go deeper

Where this sits

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Alpha Lipoic Acid 400 mg and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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