NIH DSLD registered label
Portionstorlek1-2 Capsule(s)
Portioner per container240
Supplement Facts panel, verbatim
N-Acetyl-L-Cysteine900 mg
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Redaktionellt score, paid $0
No affiliate link
No third-party test
No public analysintyg
Sample received: No
NAC (N-Acetyl-L-Cysteine) 900 mg
6.7
6.7
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
How we scored this product Show the full breakdown
Dose vs. studies (55%)
Why 7.0 of 10. Primär ingredient is NAC (evidence grade B). It delivers 150% of the trialled dose. At or above what the trial used. Read the rule →
7.0
Transparency (20%)
Why 5.0 of 10. Earned points for all doses disclosed. Lost points for no public certificate of analysis and no independent third-party testing. Read the rule →
5.0
Value (10%)
Why 9.7 of 10. Pris per effective day could not be calculated, so value defaults to the middle of the catalog. Read the rule →
9.7
Community sentiment (10%)
Why 6.0 of 10. No external reviews found, so community sentiment defaults to neutral. Community never counts as clinical evidence. Read the rule →
6.0
Formulation (5%)
Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule →
5.0
Composite
How this 6.7 is built. 0.55 × 7.0 + 0.20 × 5.0 + 0.10 × 9.7 + 0.10 × 6.0 + 0.05 × 5.0 = 6.7 out of 10. Säkerhet caps applied after.
6.7
6.7
composite
Dose vs. studies55%7.0
Transparency20%5.0
Value10%9.7
Community10%6.0
Formulation5%5.0
Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.
This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.
Question 1
Does the molecule work?
Question 1
Does the molecule work?
Question 2
Is this bottle good?
Question 2
Is this bottle good?
The specific product: dose, price, transparency, and what buyers report.
Dose vs research
150% av studiedosen
Meets or exceeds the published effective dose
Cost at trial dose
$0.28/day at trial dose
What one effective daily dose actually costs
Transparency
5.0/10 · No public analysintyg
No third-party testing disclosed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3
What's the catch?
Question 3
What's the catch?
Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.
No public analysintyg
Certificate of Analysis not published
Without a public analysintyg, batch purity and potency cannot be independently verified.
No third-party testing
Independent lab verification not disclosed
The brand does not publish evidence of independent batch testing.
Buyer complaints
Amazon: Capsule taste when opened; iHerb: Higher price than generic NAC
Recurring themes from consumer review platforms.
Redaktionellt verdict
Quick verdict
6.7
/ 10
Best for
Full trial dose, Budget-friendly
Avoid if
No public analysintyg
Full-dose status
Meets trial dose
Pris/month
$13
COA status
Not public
Biggest caveat
No public Certificate of Analysis.
The numbers
Pris
$101
per bottle · 240 portioner
Dose vs. research
Above trial dose 150%
of published effective dose
$ / day at studied dose
$0.28
what one effective daily dose costs
$ / g active
$0.47
per gram of active substance
Independently checked
Data verification
Pris
$101
Verified n/a
Dose
150% av studiedosen
Verified n/a
COA status
Not public
Verified n/a
Bevisning grade
B
Per-ingredient breakdown
BNAC
Verified n/a
All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.
What's inside
Ingredient
Dose in this product
Trial dose
Bevisning
NAC
Cysteine donor for glutathione synthesis; drug-strength efficacy for specific uses.
900.0 mg 150% av studiedosen
600 mg
Medium confidence
Source diversity: 69%
AmazonTrustpilotiHerb
PraiseGood for kids (mixed with food)Effective for lung support
ComplaintsCapsule taste when openedHigher price than generic NAC
Last checked: 2026-08-07
Consumer signals
Consumer signals gathered from 4 platforms.
Low confidence, small sampleConsumer sentiment compiled from 3 public sources.
5.0/5 · positive sentiment
PraiseGood for kids (mixed with food)Effective for lung support
ComplaintsCapsule taste when opened
ThemesAmazon reviewers, including parents giving it to children, report high satisfaction with efficacy and tolerability.
Compiled from Amazon listing located during research; verified at build time.
positive sentiment
PraiseNoticeable lung/respiratory supportDoctor recommended
ComplaintsHigher price than generic NAC
ThemesiHerb reviewers report strong outcomes for lung and respiratory health, including post-surgical recovery anecdotes.
Compiled from iHerb listing located during research; verified at build time.
4.8/5 · positive sentiment
PraiseHigh average rating for category
ComplaintsPremium pricing vs generic NAC
ThemesThird-party review aggregator healthquay notes Pure Encapsulations NAC 900mg carries an unusually high average rating for its category.
Compiled from Amazon (Trustpilot cross-reference via healthquay) listing located during research; verified at build time.
2 threads discussed · mixed sentiment
Themesgeneral brand-pricing skepticism (not specific to this SKU's potency)some commenters prefer NAC ethyl ester over standard NAC for bioavailability, a formulation debate rather than a complaint about this product
These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.
Independent external anchors
Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.
What others say, with a source hierarchy
We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.
These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.
Tier A
Independent deep reviews, lab tests, certificates of analysis
Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.
Innerbody, 'Best NAC Supplement' roundup
Has affiliate relationship
Not a paid placement
Innerbody's independently-tested NAC comparison favors other brands over Pure Encapsulations for its 'best overall' slot as of 2026.
Finding: Names Wholesome Story as best overall NAC supplement in its 2026 rankings; Pure Encapsulations' NAC 900 mg is not named as the top pick in this specific roundup.
How we use it: Used as a category-context data point; Innerbody discloses an affiliate model but applies disclosed testing methodology, so it clears the Tier A bar per this site's sourcing rules. Not used to make a claim about this specific SKU's dose or efficacy, only about competitive market positioning.
Vår sammanfattning
Pure Encapsulations' NAC 900 mg delivers a straightforward, single-ingredient dose of N-acetylcysteine with no blend without listed amounts or added actives, sold currently under FDA's enforcement-discretion policy for NAC rather than a settled legal supplement status. The strongest matching clinical evidence for NAC as an ingredient sits at 600 mg/day and above for fertility and metabolic markers, roughly two-thirds of this product's per-capsule dose, so buyers taking one capsule a day are close to but not squarely on the most-studied dose. The absence of third-party testing or a public COA for this specific SKU is the most consequential gap for a buyer trying to verify what's actually in the capsule.
Bevisning, what actually backs this product
Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.
Strongest evidence tier
Tier 3Ingredient RCT (matching dose)
4 studies mapped
Tier 3Ingredient RCT (matching dose)
Effect of N-acetylcysteine on semen parameters and oxidative/antioxidant status (male fertility RCTs, pooled)
ingredient-levelpeer-reviewed
Improved sperm quality parameters and reproductive hormone levels versus placebo across cited trials.
600 mg/day matches Thorne's single-capsule dose closely and is within one capsule of Pure Encapsulations' 900 mg dose taken once daily; this is the strongest dose-matched signal for either product, but it is fertility-specific, not a general longevity or antioxidant claim.
Conflicts: None identified (as reported in secondary review)
Tier 4Ingredient RCT (different dose)
N-acetylcysteine improves biochemical and clinical response in patients with mild to moderate metabolic dysfunction-associated steatotic liver disease (randomiserad kontrollerad studie)
ingredient-levelpeer-reviewed
No significant effect on liver enzymes or steatosis grade, but significantly increased total glutathione (552.1 to 641.9 mmol/L, p=0.003) and reduced fasting glucose, insulin, HOMA-IR, and CRP.
Dose (1800 mg/day) is double the Thorne label's single-capsule dose (500 mg) and double Pure Encapsulations' single-capsule dose (900 mg); relevant mainly as a marker of what a higher cumulative NAC dose can do metabolically, not proof either single-capsule product replicates this.
Conflicts: None identified
Tier 5Mechanistic / animal / marketing
N-Acetylcysteine: Impacts on Human Health
ingredient-levelpeer-reviewed
Summarizes multiple RCTs showing NAC reduces oxidative stress markers and has modest, condition-specific benefits (COPD mucolysis, male fertility, some psychiatric adjunct use); effects are dose- and population-dependent, not uniform.
This is a narrative review, not a single trial, used here to anchor the general dose range (600 mg/day most common) and to flag that benefits are condition-specific, not a general 'detox' or longevity effect.
Conflicts: None identified
Tier 5Mechanistic / animal / marketing
Effect of Combined Glycine and N-Acetylcysteine Supplementation on Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, and Physical Function in Older Adults (GlyNAC pilot RCT)
ingredient-levelpeer-reviewed
Did not meet its primär endpoint of raising total glutathione across the full cohort; a post-hoc subgroup with high baseline oxidative stress and low glutathione showed an increase at medium/high doses (p=0.016).
NAC is combined with glycine here (not standalone), at doses several-fold higher than either product's per-capsule NAC amount, and the primär endpoint was negative for the overall group, this is supportive of a biological rationale, not proof that a single 500-900 mg NAC capsule raises glutathione.
Conflicts: Academic-funded (Baylor College of Medicine); no vendor sponsorship identified
Bevisning
Research behind this product
The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.
Claim check, vendor claims vs. our reading of the evidence
Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.
Partial support
“NAC supplements are legal to sell in the US”
True in practice today, but only because FDA is exercising enforcement discretion (final guidance issued augusti 1, 2022) after having taken the position in 2020 that NAC is excluded from the legal definition of a dietary supplement. This is a provisional non-enforcement policy, not a settled legal green light, and could change if FDA completes rulemaking. Buyers should understand NAC's US legal status is administratively tolerated, not statutorily secure (https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-policy-regarding-n-acetyl-l-cysteine).
N/A, general market fact, not a specific vendor claim
Partial support
“Supports respiratory health and antioxidant/glutathione status (general ingredient positioning; page does not make disease claims)”
NAC is a legitimate glutathione precursor and is a licensed mucolytic drug in many countries at similar doses, so the mechanistic basis is real. But the vendor page does not cite a specific RCT, and the strongest human evidence (male fertility, MASLD glutathione increase) is at 600-1800 mg/day, not clearly matched to the exact 900 mg once- or twice-daily label dose. General 'antioxidant support' framing outruns the specificity of the underlying trials (https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/).
Regelverk status
Rules change often. We record when we last verified each row. See the full regulatory timeline →
What we could not verify
We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.
- No public Certificate of Analysis or independent third-party lab test found for this specific SKU, actual NAC content and purity cannot be independently confirmed.
- No peer-reviewed RCT was located using this exact product (Pure Encapsulations' 900 mg capsule) as the study material; all cited evidence is at the ingredient level using different doses.
- The product page does not disclose a specific clinical citation for its general 'antioxidant support' positioning.
- Long-term safety of chronic daily use above 1200 mg/day (i.e., 2+ capsules) has not been established by dedicated long-duration RCTs in this review.
Important to know
NACSmells like sulfur (rotten eggs). Enteric-coated forms reduce this. Don't combine with nitrates without medical supervision.
Redaktionellt notes
Straightforward single-ingredient 900mg NAC capsule at a market-typical dose for glutathione precursor support; priced at the higher end for practitioner-channel NAC (~$0.42-0.84/day depending on 1-2 capsule dosing).
In plain language
Why this scored this way
This Pure Encapsulations NAC (N-Acetyl-L-Cysteine) 900 mg scores 6.7, making it a mid-tier product with both strengths and weaknesses. It delivers the full 900.0mg trial dose of NAC with grade B evidence (promising human data, not yet comprehensive). The quality transparency (5.0) is limited by the lack of third-party testing. At $0.28/day it's priced well for what you get.
What drives the score up
- Dose-evidence score of 7.0 shows decent alignment with trial doses.
- Value score of 9.7 at $0.28/day.
- NAC is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).
What drags it down
- No third-party testing, which caps the quality transparency.
- Quality transparency of 5.0 is below the site average.
- Limited consumer feedback (community score: 6.0).
Why you'd choose it
- You want good value at $0.28/day.
- You want NAC from a Pure Encapsulations product.
- You want doses that align with published research.
Why you might skip it
- You want third-party verified purity.
- You want a product with a publicly available CoA.
- You want stronger transparency (this scores 5.0).
Go deeper
Where this sits
Varumärke owners
Spot an error?
If you are the manufacturer or brand owner of NAC (N-Acetyl-L-Cysteine) 900 mg and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.
We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.
Request a correction →Same shelf
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