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Liposomal NMN

NAD+ booster · Liposomal capsule · 30 portioner#20 / 46 in NAD+ booster
6.8
Overall score · out of 10
6.8
Overall score · out of 10
Dose vs. studies6.6
Transparency8.5
Value3.0
Community7.5
Formulation8.0
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
Redaktionellt score, paid $0 No affiliate link Tested by independent lab Public analysintyg Sample received: No
How we scored this product Show the full breakdown
Composite How this 6.8 is built. 0.55 × 6.6 + 0.20 × 8.5 + 0.10 × 3.0 + 0.10 × 7.5 + 0.05 × 8.0 = 6.8 out of 10. Säkerhet caps applied after. 6.8
6.8 composite
Dose vs. studies55%6.6
Transparency20%8.5
Value10%3.0
Community10%7.5
Formulation5%8.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

A NAD+ building block that has become the most-hyped longevity molecule.

5 landmark RCTs · US: FDA NDI status volatile (juli 2026) · EU: Unauthorised Novel Food (EFSA positive maj 2026, no Commission listing yet)
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
50% av studiedosen
Below the full trial dose
Cost at trial dose
$5.27/day at trial dose
What one effective daily dose actually costs
Transparency
8.5/10 · Public analysintyg (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No major red flags
Public analysintyg, tested by independent lab, dose within range
No safety, transparency, or dose concerns detected at this time.
Redaktionellt verdict

Quick verdict

6.8 / 10
Best for
Public analysintyg
Avoid if
Only 50% av studiedosen
Full-dose status
50% av studiedosen
Pris/month
$79
COA status
Public
Biggest caveat
Dose is 50% of the trial dose.
Nearest alternatives

The numbers

Pris
$79
per bottle · 30 portioner
Dose vs. research
Below trial dose 50%
of published effective dose
$ / day at studied dose
$5.27
what one effective daily dose costs
$ / g active
$10.53
per gram of active substance
Independently checked

Data verification

Pris
$79
Verified n/a
Dose
50% av studiedosen
Verified n/a
COA status
Public
Verified n/a
Bevisning grade
B
Per-ingredient breakdown
BNMN
Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Bevisning
NMN
A NAD+ building block that has become the most-hyped longevity molecule.
250 mg 50% av studiedosen
500 mg

Consumer signals

Consumer signals gathered from 2 platforms.

Low confidence, small sample

Consumer sentiment compiled from 2 public sources (Reddit, YouTube). Small sample size, treat as directional only.

1 threads discussed · positive sentiment

PraiseInterview with Greg Macpherson; discusses liposomal delivery rationale (not head-to-head data).

Compiled from a YouTube, Modern Healthspan listing located during manual research; not independently re-verified against the live page at build time.

1 threads discussed · mixed sentiment

ThemesUsers like the delivery hypothesis but flag that human head-to-head data is thin.

Compiled from a Reddit r/longevity listing located during manual research; not independently re-verified against the live page at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site
SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, Yes

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Trustpilot (renuebyscience.com, US)
No affiliate relationship Not a paid placement

Reviewers overwhelmingly report a positive experience, citing perceived product quality/purity, noticeable energy and focus effects, and reliable shipping; a minority flag order-change and customer-service response-time issues, and Renue replies to 100% of negative reviews.

Finding: 4.4/5 ('Excellent') aggregate rating from 172 reviews on the US Trustpilot listing at time of check; a separate French-language Trustpilot listing shows 4.0/5 from 64 reviews.
How we use it: Used as company-wide reputation signal (N under 500, below the brief's Tier-A threshold of N>500 for unconditional acceptance, but usable as Tier B with disclosure). Reflects brand-level sentiment across Renue's full catalog, not specifically the liposomal NMN SKU.
r/Biohackers (Reddit), 'Exposing Renue by Science Scam (CellG8 liposomal delivery system bioavailability claims)'
No affiliate relationship Not a paid placement

A detailed, methodologically transparent independent critique (no disclosed affiliate relationship) concluding Renue's liposomal bioavailability multipliers are unsubstantiated by any locatable primär source, and that the same CellG8 marketing pattern (unlinked/unverifiable studies) extends to other CellG8 produkter including Liposomal NMN.

Finding: Author reports being unable to locate any published study supporting Renue's advertised '10x more bioavailable' claim for Lipo EGCG Green Tea despite extensive Google Scholar/PubMed searches, and flags that the cited blood-concentration figures (e.g., a precise 10-fold ratio) look marketing-derived rather than data-derived.
How we use it: Directly corroborates our own inability to verify Renue's general liposomal-bioavailability multiplier claims; used as the primär independent counterweight to Renue's own marketing language in claim_check.
r/NMN (Reddit), multiple threads, aggregated hobbyist sentiment
No affiliate relationship Not a paid placement

r/NMN carries a large volume of Renue-specific hobbyist discussion; sentiment is broadly favorable on trust/legitimacy ('they're totally legit') but genuinely mixed on subjective efficacy, and only a handful of posters report having done independent before/after NAD+ blood testing, none of which isolates the liposomal format's specific contribution versus NMN itself.

Finding: Mixed self-report: individual anecdotes range from 'no effect at all' after 2 years of use, to self-tested NAD+ blood levels of 56 µM via a Jinfiniti test (vendor states ~30 µM average for the user's age bracket, 40+ considered optimal) after starting Renue's LIPO NMN plus NAD+ nasal spray, to a separate user reporting a third-party lab test found Renue's liposomal NMN contained ~11% more NMN than the label claimed.
How we use it: Used as qualitative color on real-world user experience and to confirm the near-total absence of rigorous user-run PK experiments (no user was found who tested liposomal vs. standard NMN head-to-head on themselves). Individual self-reports are not generalizable and are not blinded/controlled.
The NAD Review, 'Renue By Science Liposomal NMN Review (2026)'
Has affiliate relationship Not a paid placement

A comparatively rigorous affiliate review that discloses the commercial relationship, correctly characterizes the vendor trial as a small, unpublished, industry-associated pilot rather than proof, and concludes Renue is 'a credible product wrapped in an unproven delivery promise', worth a look for buyers who specifically want liposomal NMN and value published COAs, but not a basis to expect a demonstrated absorption advantage.

Finding: Explicitly states the Kawakami 2025 trial 'is not indexed on PubMed and has not, to our knowledge, been published in a peer-reviewed journal' and that 'there is no published, peer-reviewed human trial showing that any liposomal NMN product raises blood NAD+ better than ordinary oral NMN.'
How we use it: Used as a Tier-B corroborating source (affiliate-disclosed, but methodology-transparent and skeptical rather than promotional) that independently reaches the same skeptical conclusion on the liposomal-superiority claim as this dossier.
Rejected

Sources we transparently discard

Marketing-quoted press, obviously fabricated aggregate ratings, or heavy-affiliate 'reviews'. Listed openly so you can see what we excluded.

Biohacker Atlas, 'Renue By Science Review 2026'
Has affiliate relationship Not a paid placement

Repackages vendor marketing uncritically and introduces a fabricated/unverifiable detail (the actual paper's authors and affiliations are Kiryu University and Maeda Clinic in Japan, there is no Ohio University connection in the primär source), while presenting the non-indexed pilot study as 'peer-reviewed' validation.

Finding: Claims the Kawakami trial was 'funded at Ohio University' and constitutes 'peer-reviewed bioavailability validation' with '361% better absorption.'
How we use it: Rejected per the brief's two-question test: it repackages marketing rather than independently evaluating the product, and introduces an apparent factual fabrication about the study's institutional origin. Flagged here as a caution against citing this source anywhere else in the pipeline.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

YouTube, Modern Healthspan
positive

Interview with Greg Macpherson; discusses liposomal delivery rationale (not head-to-head data).

Read source → Unverified · we received no payment for this listing
Reddit r/longevity
mixed

Users like the delivery hypothesis but flag that human head-to-head data is thin.

Read source → Unverified · we received no payment for this listing

Vår sammanfattning

Renue By Science's LIPO NMN delivers 250 mg of powder-encapsulated liposomal NMN per capsule (500 mg/day at the labeled 2-capsule serving) for $64.95/90 capsules, positioned as a bioavailability upgrade over standard NMN via the company's proprietary CellG8 liposome technology. The general case for oral NMN raising blood NAD+ is reasonably well established in humans (Yoshino 2021, Igarashi 2022, and a 2024/2025 wave of pooled RCTs), but every one of those trials used standard, non-liposomal NMN, there is no independently replicated, peer-reviewed human evidence that liposomal encapsulation specifically improves on that baseline. The one study Renue cites for its 84%-NAD+-increase/liposomal-superiority claim (Kawakami et al. 2025) is real but is a 15-person pilot published in a journal not indexed on PubMed and flagged as potentially predatory, making it Tier 4 evidence at best and a weak reed for a brand-defining marketing claim. On the US regulatory front, NMN's legal status improved materially in september 2025 when the FDA reversed its 2022 drug-preclusion exclusion, and Renue continued shipping throughout the intervening uncertainty. Buyers should treat this as a legitimate, transparently-COA'd NMN product from an established direct-to-consumer brand, but should not pay a liposomal premium expecting a proven absorption advantage over cheaper standard NMN.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 4Ingredient RCT (different dose)
6 studies mapped
Tier 0No source
Effects of nicotinamide mononucleotide on glucose and lipid metabolism in adults: a systematisk översikt and metaanalys of randomised controlled trials
Chen F, Zhou D, Kong APS, Yim NT, Dai S, Chen YN, Hui LL · 2025 · Current Diabetes Reports · n=342 · 250-2000 mg/day standard oral NMN across pooled trials · 14 days to 12 weeks
ingredient-levelpeer-reviewed
Pooled metaanalys of 8 human NMN RCTs (2021-2023) found no significant benefit of NMN supplementation on fasting glucose, fasting insulin, HbA1c, HOMA-IR, or lipid profile.
Underscores that even the accepted human RCT base for standard NMN shows a mixed/null result on hard metabolic endpoints; none of the pooled trials used liposomal formulations. Directly tempers any inference that a NAD+ blood-level rise (as claimed for Renue's liposomal product) automatically translates into metabolic benefit.
Conflicts: Academic review; no industry funding disclosed.
Tier 0No source
DMPC-Based Liposomal Vesicles for Encapsulation and Controlled Release of NMN and Matrigel in Sarcopenia Therapy
Various (in vitro liposome-formulation study) · 2025 · International Tidskrift of Molecular Sciences · Not applicable (in vitro concentrations) · Not applicable
ingredient-levelpeer-reviewed
A DMPC liposomal NMN formulation reduced oxidative damage and preserved mitochondrial function in cultured muscle cells better than free NMN in an in vitro model.
Representative of the broader liposomal-NMN literature: virtually all published liposomal-NMN research is in vitro, ex vivo (skin-penetration), or animal-model work on formulation characteristics, not human oral pharmacokinetics. Confirms mechanistic plausibility of liposome-enhanced cellular uptake, but does not establish a human absorption advantage.
Conflicts: No disclosed link to Renue By Science.
Tier 4Ingredient RCT (different dose)
Intervention Studie Comparing Blood NAD+ Concentrations with Liposomal and Non-Liposomal Nicotinamide Mononucleotide
Kawakami S, Maeda Y, Fukuzawa Y · 2025 · Annals of Clinical Medicine and Case Reports (ACMCR), published by United Prime Publications LLC · n=15 · 350 mg/day (liposomal NMN arm) vs 350 mg/day standard NMN vs placebo (4 g/day maltodextrin) · 4 weeks supplementation + 4-week washout
ingredient-levelnot peer-reviewed
The liposomal-NMN arm showed the largest rise in whole-blood NAD+ (28.6 to 52.5 µM, ~84%) after 4 weeks, exceeding both the standard-NMN and placebo arms, with levels still elevated at 36 µM four weeks after stopping.
This is the ONLY head-to-head human liposomal-vs-standard NMN comparison located anywhere in the literature, and it is directly relevant to Renue's core marketing claim, but it is a major red flag on methodology and independence: (1) n=5 per arm is a pilot-scale sample with no statistical power for a definitive claim; (2) the journal (Ann Clin Med Case Rep / ACMCR, publisher 'United Prime Publications LLC') is not indexed on PubMed/MEDLINE and its near-identical sister title 'Annals of Clinical Case Reports' appears on librarian Jeffrey Beall's list of potential predatory journals (https://www.beallslist.us/standalone-journals), indicating minimal or no real peer review; (3) the paper does not disclose any Renue/CellG8/industry funding or material-supply relationship in the excerpt reviewed, but Renue is the only entity actively promoting and monetizing this exact result, and no author affiliation links to an academic PK/liposome lab; (4) the dose tested (350 mg/day) does not match Renue's actual retail dose (500 mg/day, 250 mg/capsule x2). This should be treated as a preliminary, unreplicated pilot finding, not confirmatory evidence that liposomal NMN outperforms standard NMN in humans.
Conflicts: Not disclosed in the available excerpt; publisher is a low-oversight open-access outlet flagged as potentially predatory. No independent replication exists.
Tier 5Mechanistic / animal / marketing
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino M, Yoshino J, Kayser BD, et al. · 2021 · Science · n=25 · 250 mg/day standard (non-liposomal) oral NMN · 10 weeks
ingredient-levelpeer-reviewed
The most rigorous human NMN RCT to date found modest improvement in muscle insulin sensitivity with standard oral NMN, without a measurable rise in blood NAD+ itself.
Flagship general NMN evidence, but it used standard (non-liposomal) NMN at 250 mg/day, half of Renue's 500 mg/day liposomal dose, in a narrow population, and measured a metabolic endpoint, not the general energy/anti-aging claims on Renue's page. Not a study of Renue's liposomal formulation or CellG8 technology.
Conflicts: None identified; academic study (Washington University School of Medicine) with NIH funding.
Tier 5Mechanistic / animal / marketing
Effect of nicotinamide mononucleotide on brain aging and cognitive impairment in humans and mice
Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. · 2022 · npj Aging · n=10 · 250 mg/day standard oral NMN · 12 weeks
ingredient-levelpeer-reviewed
A small open-label/RCT sub-study found standard oral NMN safely raised blood NAD+ metabolites and was associated with improved measures of gait speed and cognitive test performance versus baseline.
Very small sample (n=10), uses standard (non-liposomal) NMN at half Renue's per-serving dose, and mixes an open-label human component with mouse data. Not applicable to liposomal delivery specifically.
Conflicts: Academic Japanese study; no disclosed link to Renue.
Tier 5Mechanistic / animal / marketing
Säkerhet and efficacy of nicotinamide mononucleotide supplementation in middle-aged and older adults: a longer-duration RCT
Yamauchi M, et al. (representative of the 2024 wave of longer NMN human trials) · 2024 · GeroScience / related journals (see systematisk översikt below for aggregate) · 250-2000 mg/day standard oral NMN across pooled trials · 14 days to 12 weeks across pooled trials
ingredient-levelpeer-reviewed
A 2024 systematisk översikt with metaanalys of randomized NMN trials found an overall significant effect on raising blood NAD+ levels, but most clinically relevant outcomes (e.g., glucose/lipid markers) were not significantly different from control.
Referenced here to represent the broader 2021-2024 wave of standard-oral-NMN human RCTs (Yoshino 2021, Igarashi 2022, and subsequent 2023-2024 trials). None of the RCTs identified in this literature, including this pooled review, used a liposomal formulation, the entire published human RCT base for NMN is built on standard oral/sublingual NMN, not liposomal NMN.
Conflicts: Academic metaanalys; no disclosed industry funding located.
Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support
“'LIPO NMN features our proprietary, powder-based liposomes that protect NMN from digestive enzymes & carry it into the bloodstream for targeted systemic delivery.'”
The mechanistic premise, that liposomal encapsulation can protect a fragile, water-soluble molecule like NMN from gastric and brush-border enzymatic degradation, is plausible and supported by in vitro/ex vivo liposome literature (e.g., the DMPC-liposome NMN sarcopenia study, PMID 40565060). However, 'targeted systemic delivery' implies a demonstrated human pharmacokinetic advantage that has not been independently confirmed; the only human comparison (Kawakami 2025) is a small, non-peer-reviewed pilot published in a low-oversight journal.
Not supported
“Liposomal NMN increased blood NAD+ by 84% versus standard NMN and placebo in a clinical trial (implying liposomal delivery is proven superior to standard NMN).”
The underlying study (Kawakami et al. 2025, Ann Clin Med Case Rep) is real and does report this number, but it is a pilot trial with n=5 per arm, published in a journal not indexed on PubMed/MEDLINE whose closely related sister title appears on librarian-maintained predatory-journal watchlists (https://www.beallslist.us/standalone-journals). No independent replication exists, no funding/COI disclosure was found, and the tested dose (350 mg/day) does not match Renue's retail dose (500 mg/day). An independent product-review site (thenadreview.com) reached the same conclusion: 'This study is not indexed on PubMed and has not, to our knowledge, been published in a peer-reviewed journal... it should be described as company-reported, not as a peer-reviewed finding.' We treat the 84% figure as a real but very low-confidence pilot result, not proof that liposomal NMN outperforms standard NMN in humans.
Unverifiable
“'With our Liposomal produkter, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is' / '10x more bioavailable' for Lipo Green Tea EGCG.”
A detailed independent critique (r/Biohackers, 'Exposing Renue by Science Scam') found that Renue's cited 'clinical trial' for the specific 10x EGCG bioavailability figure has no working link, could not be located on Google Scholar or PubMed, and the precise 10-fold blood-concentration figures cited by Renue read as marketing-selected round numbers rather than derived statistics. The claim that '90% of the payload reaches the bloodstream intact regardless of what the payload is' is an extraordinary, non-ingredient-specific claim with no cited primär source; we could not verify it for NMN specifically.
Partial support
“'NMN...has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.'”
Multiple standard (non-liposomal) oral NMN RCTs (Yoshino 2021, PMID 33888596; Igarashi 2022, PMID 35236878; Okabe 2022, frontiersin.org/10.3389/fnut.2022.868640) do show NMN raises blood NAD+ metabolites in humans, and this general statement about NMN (not specifically liposomal NMN) is reasonably well supported. It is misleading only insofar as it appears on a page marketing a liposomal product, implying the liposomal format specifically shares this evidence base, when the cited clinical-trial base is entirely standard-format NMN.
Unverifiable
“'Liposomes release the payload over a much longer period, up to 24 hours. This is better when taking larger dosages.'”
This is a plausible pharmaceutical property of liposomal/sustained-release formulations in general, but no NMN-specific human release-kinetics data was located to confirm a 24-hour release window for Renue's CellG8 powder liposomes, nor evidence that a slower release meaningfully improves outcomes versus faster absorption routes (e.g., sublingual).

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • Whether the Kawakami et al. 2025 trial disclosed any funding, material-donation, or consulting relationship with Renue By Science or its CellG8 technology licensor, the excerpt reviewed does not include a conflict-of-interest statement, and the journal's editorial rigor is questionable.
  • Whether every batch/lot of LIPO NMN sold to customers has a matching, dated, publicly verifiable COA, versus a representative example COA displayed on the product page.
  • The exact 'CellG8' liposome manufacturing process (lipid composition, particle size, encapsulation efficiency) has not been independently characterized or published for the NMN-specific product; the only comparable liposome-characterization data found in the literature (e.g., PMID 40565060, PMID 41383026) are from unrelated academic groups using different liposomal chemistries, not Renue's proprietary process.
  • Whether Renue's current 250 mg-per-capsule NMN content matches label claims lot-to-lot; the single independent Reddit report of '11% more NMN than listed' is a single anecdote, not a systematic audit.
  • The true independent (non-brand-run) Trustpilot and Reddit sentiment base size, review counts varied across sources checked (172 on trustpilot.com US in one snapshot, 64 on the French site, ~211-545 cited by third-party review blogs), suggesting these aggregator figures fluctuate and some site-authored 'reviews' pages may blend incentivized/compensated testimonials with organic reviews.
Important to know
NMNAbsorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.

Redaktionellt notes

Claims 3 to 5× absorption vs powder. Human head-to-head data thin.

In plain language

Why this scored this way

This Renue By Science Liposomal NMN scores 6.8, making it a mid-tier product with both strengths and weaknesses. It delivers 250mg of NMN (50% of the 500mg trial dose) with grade B evidence (promising human data, not yet comprehensive). At $5.27/day it's among the more expensive options in NAD+ booster.

What drives the score up

  • Dose-evidence score of 6.6 shows decent alignment with trial doses.
  • Tested by independent lab (transparency 8.5).

What drags it down

  • At $5.27/day it's on the expensive side.

Why you'd choose it

  • You want NMN from a Renue By Science product.
  • You prioritise tested by independent lab produkter with public lab certificates.

Why you might skip it

  • You want a cheaper option (this is $5.27/day).
Go deeper

Where this sits

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Liposomal NMN and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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