Curcumin Phytosome (formerly Meriva 500-SF)

Belcaro et al. 2010 Mohseni et al. 2025 (Frontiers in Nutrition)Bahari et al. 2025 (Inflammopharmacology)

Curcumin Phytosome (formerly Meriva 500-SF)

Name: Curcumin Phytosome (formerly Meriva 500-SF)
Brand: Thorne HealthTech
SKU: thorne-curcumin-phytosome
Price: 36.0 USD
Availability: InStock
Rating: 4.49 (6839 reviews)

Antioxidant · Capsule · 60 portioner#2 / 25 in Antioxidant

7.8

Overall score · out of 10

7.8

Overall score · out of 10

Dose vs. studies8.0

Transparency8.0

Value9.3

Community6.0

Formulation5.0

Tier 2

Product RCT (not peer-reviewed)

Product-specific RCT exists but was not peer-reviewed.

Redaktionellt score, paid $0 No affiliate link Tested by independent lab No public analysintyg Sample received: No

How we scored this product Show the full breakdown

Dose vs. studies (55%) 8.0

Transparency (20%) 8.0

Value (10%) 9.3

Community sentiment (10%) 6.0

Formulation (5%) 5.0

Composite 7.8

7.8 composite

Dose vs. studies55%8.0

Transparency20%8.0

Value10%9.3

Community10%6.0

Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Curcumin Grade B

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

4 landmark RCTs · US: GRAS · EU: Food supplement

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

100% av studiedosen

Meets or exceeds the published effective dose

Cost at trial dose

$0.60/day at trial dose

What one effective daily dose actually costs

Transparency

8.0/10 · No public analysintyg

Independent batch testing confirmed

Consumer signals

6,839 reviews across platforms · 4.5/5 · high confidence

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Säkerhet signals

Exceeds upper intake limit — curcumin

1000.0 mg per portion exceeds the tolerable upper intake level of 210.0 mg/day. EFSA Acceptable Daily Intake (ADI) is 3 mg/kg bw/day (≈210 mg/day for a 70 kg adult); FDA GRAS notifications support up to 1,000 mg/day, and short-term trials have used 8-12 g/day safely for up to 3 months.

Läs mer

Liver safety signal — curcumin

Cases of drug-induced liver injury associated with curcumin/turmeric supplements have been reported. Most involved formulations with enhanced bioavailability (phytosome, nanoparticles) or doses above 1,000 mg/day. EFSA set an ADI of 3 mg/kg bw/day (≈210 mg/day for 70 kg). Doses up to 1,000 mg/day of standard extracts have been generally tolerated in trials.

Läs mer

Drug interaction risk — curcumin

Inhibits CYP2C9 and CYP3A4 (moderate effects on CYP2B6, CYP1A2, CYP2D6). Interacts with warfarin and other vitamin K antagonists (elevated INR reported), NSAIDs, antiplatelet agents, antihyperlipidemics, and reduces iron absorption via chelation.

Läs mer

No public analysintyg

Certificate of Analysis not published

Without a public analysintyg, batch purity and potency cannot be independently verified.

Buyer complaints

Trustpilot: unresponsive customer service; Trustpilot: shipping delays cited by 69% of one-star reviews

Recurring themes from consumer review platforms.

Best for

Full trial dose, Budget-friendly

Avoid if

No public analysintyg

Full-dose status

Meets trial dose

Pris/month

$18

COA status

Not public

Biggest caveat

No public Certificate of Analysis.

Nearest alternatives

Memory Support (formerly Omega Memory) Nordic Naturals · Poäng 6.6
Jarrow Formulas Curcumin Phytosome (Meriva), 500 mg Jarrow Formulas · Poäng 6.4
Ultimate Omega + Curcumin Nordic Naturals · Poäng 6.4

The numbers

Pris

$36

per bottle · 60 portioner

Dose vs. research

Överensstämmer med studier 100%

of published effective dose

$ / day at studied dose

$0.60

what one effective daily dose costs

$ / g active

$0.60

per gram of active substance

Independently checked

Data verification

Pris

$36

Verified n/a

Dose

100% av studiedosen

Verified n/a

COA status

Not public

Verified n/a

Bevisning grade

Per-ingredient breakdown

BCurcumin

Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Bevisning

Curcumin

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

1000.0 mg 100% av studiedosen

1000 mg

3.5 /5

High confidence

6,839 reviews across 3 platforms (3 sources)

Source diversity: 69%

AmazonRedditTrustpilot

Praiseeffective anti-inflammatorypain relief for joints

Complaintsunresponsive customer serviceshipping delays cited by 69% of one-star reviews

Last checked: 2026-08-07

Consumer signals

4.49 out of 5 across 6,839 verified reviews on 4 platforms.

High confidence

Consumer sentiment compiled from 3 public sources.

Trustpilot

39 reviews · 2.1/5 · negative sentiment

Complaintsunresponsive customer serviceshipping delays cited by 69% of one-star reviews

ThemesThorne's brand-level Trustpilot score is poor, driven almost entirely by customer service and shipping complaints rather than product quality.

Compiled from Trustpilot listing located during research; verified at build time.

Amazon

6,800 reviews · 4.5/5 · positive sentiment

Praiseeffective anti-inflammatorypain relief for jointshigh absorption (Meriva form)

ThemesAmazon reviews for Curcumin Phytosome are strongly positive, citing real pain and inflammation relief with roughly 6,800+ reviews at 4.5 stars.

Compiled from Amazon listing located during research; verified at build time.

6 threads discussed · positive sentiment

Praisehelps inflammation, e.g. finger/joint pain after climbing

Themesr/Supplements and r/Biohackers users report consistent anti-inflammatory benefits using Thorne's Meriva-based Curcumin Phytosome.

Compiled from Reddit listing located during research; verified at build time.

Reddit r/Supplements

2 threads discussed · mixed sentiment

Themespeople ask whether Meriva actually beats other curcumin formulations before buyinggeneral Thorne brand skepticism since its 2023 acquisition and R&D team changes

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site

SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes

NIH DSLD registered label

DSLD ID 290208, UPC 6 93749 00485 1

Portionstorlek1-2 Capsule(s)

Portioner per container30

Supplement Facts panel, verbatim

Meriva1 Gram(s)

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Examine.com, Curcumin page

No affiliate relationship Not a paid placement

Independent evidence-synthesis support for the category-level premise that enhanced-bioavailability curcumin formulations (like this Meriva-based product) are more likely to be clinically effective than unformulated turmeric extract.

Finding: Examine's evidence-based summary generally rates curcumin's evidence for joint pain/osteoarthritis symptom relief as moderate, contingent on using a bioavailability-enhanced formulation such as a phytosome or piperine-combined product rather than plain turmeric powder.

How we use it: Used as independent ingredient-category context supporting the phytosome-formulation rationale, not as product-specific confirmation.

NSF Certified for Sport product registry

No affiliate relationship Betald placering

Independently audited confirmation that this exact product passes NSF's banned-substance and label-accuracy screening, though brands pay for this certification program (a paid but methodologically independent testing/audit model).

Finding: Thorne's Curcumin Phytosome product is listed in NSF's certified-product database confirming current certification status.

How we use it: Used as direct, product-specific quality-certification evidence.

Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Reddit r/Supplements consensus threads on Meriva/curcumin phytosome produkter

No affiliate relationship Not a paid placement

Directionally consistent with the formal evidence base but not a rigorous or independently verifiable data source.

Finding: Informal community discussion generally regards Meriva-based curcumin produkter, including Thorne's, as among the better-absorbed and better-evidenced curcumin formulations on the market, though without disclosed methodology or systematic sampling.

How we use it: Used only as low-confidence directional color, explicitly labeled Tier C due to lack of disclosed methodology.

Vår sammanfattning

Thorne's Curcumin Phytosome uses the Meriva curcumin-phosphatidylcholine complex (Indena S.p.A.), one of the more clinically studied curcumin delivery formulations, and this dossier's evidence review places it among the stronger cases in this comparison set: a peer-reviewed pharmacokinetic study found roughly 29-fold higher blood curcuminoid exposure versus unformulated curcumin, and two Belcaro-group RCTs at the exact branded complex and a matching 1 g/day total dose found substantial WOMAC osteoarthritis symptom improvements sustained over 3 and 8 months. These are genuine Tier 2 findings, on the exact ingredient complex, at a comparable dose, rather than merely ingredient-category extrapolation, which is unusual for a supplement in this catalog. That said, the clinical trial series is concentrated among a small, overlapping group of investigators with unclear disclosure of Indena's own funding role, and one reported biomarker value (a baseline CRP of ~168 mg/L) is unusually high for typical osteoarthritis patients and could not be independently reconciled from available abstracts. The product carries a genuine, independently audited NSF Certified for Sport mark, a meaningfully stronger quality signal than most produkter in this catalog, though no independent lab has published potency-verification data for this specific finished capsule.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 2Product RCT (not peer-reviewed)

4 studies mapped

Tier 2Product RCT (not peer-reviewed)

Product-evaluation study on a curcumin phytosome complex in patients with osteoarthritis

Belcaro G, Cesarone MR, Dugall M, et al. · 2010 · Panminerva Medica · n=50 · 1 g/day Meriva (this product's exact branded complex, providing ~200 mg curcuminoids), taken as a single daily dose rather than this product's labeled 2x/day split dosing · 3 months

on this exact productpeer-reviewed

WOMAC osteoarthritis symptom score decreased approximately 58% in the treatment group; C-reactive protein (an inflammation marker) fell from a mean of ~168 mg/L to ~11.3 mg/L.

This is the strongest evidence in this dossier: a peer-reviewed RCT on the exact branded ingredient complex in this product at a comparable total daily dose (though at a different dosing split, once daily vs. this product's labeled twice-daily regimen). The extremely elevated baseline CRP values (168 mg/L is far above typical osteoarthritis inflammation levels) suggest either a highly inflamed subpopulation or a reporting/units issue in the original paper that this dossier could not independently resolve, flagged as a limitation.

Conflicts: Not fully disclosed in the abstract reviewed; Meriva is an Indena S.p.A. proprietary ingredient, and Indena-affiliated or Indena-funded research is common in this ingredient's trial history, a relevant sponsor-proximity consideration even where not explicitly declared

Tier 2Product RCT (not peer-reviewed)

Product evaluation of a curcumin phytosome complex during extended administration in osteoarthritis patients

Belcaro G, Hosoi M, Pellegrini L, et al. · 2010 · Alternative Medicine Review · n=100 · 1 g/day Meriva (this product's exact branded complex) · 8 months

on this exact productpeer-reviewed

WOMAC score decreased more than 50% from baseline; Karnofsky Performance Status score improved from a mean of 73.3 to 92.2, and use of concomitant NSAID/analgesic medication substantially decreased in the treatment group.

A longer-duration extension of the same research group's earlier trial, again on the exact branded complex at a matching total daily dose, reinforcing the 3-month result with sustained benefit at 8 months, though from the same research group and Indena-linked ingredient lineage as the first trial rather than an independent replication.

Conflicts: Not fully disclosed in the abstract reviewed; same Indena-proximate research lineage as the 2010 3-month trial above

Tier 2Product RCT (not peer-reviewed)

Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation

Cuomo J, Appendino G, Dern AS, et al. · 2011 · Tidskrift of Natural Produkter · Single-dose comparison of unformulated curcumin mixture vs. Meriva phytosome-complexed curcumin (this product's exact complex) · Single-dose pharmacokinetic sampling

on this exact productpeer-reviewed

The phytosome-complexed formulation produced approximately 29-fold higher plasma curcuminoid area-under-curve (AUC) exposure than the equivalent dose of unformulated curcumin powder.

This is the bioavailability study underlying the vendor's headline absorption claim; it is a real, peer-reviewed pharmacokinetic trial on the exact ingredient complex, though it measures blood exposure (a surrogate/pharmacokinetic endpoint), not a clinical symptom outcome on its own.

Conflicts: Not fully disclosed in the abstract reviewed; involves Indena-affiliated formulation technology

Tier 3Ingredient RCT (matching dose)

Efficacy and safety of curcumin and curcumin phytosome complexes: systematisk översikt and metaanalys

Multiple contributing trials, reviewed in various systematic reviews · 2023 · Various (review context) · Varied across pooled trials · Varied

ingredient-levelpeer-reviewed

Reviews compiling the Meriva/curcumin phytosome osteoarthritis trial data generally characterize the phytosome formulation's evidence base as more consistent than unformulated curcumin's, though still limited to a small number of trials concentrated among overlapping research groups.

Useful as an independent-review lens on how the concentrated Meriva trial literature (mostly from Belcaro and colleagues) is regarded in the broader curcumin research community, it is not itself a new trial and does not resolve the sponsor-proximity limitation of the underlying primär studies.

Conflicts: Not applicable, narrative synthesis

Curcumin Belcaro et al. 2010

Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Curcumin Mohseni et al. 2025 (Frontiers in Nutrition)

Curcumin Bahari et al. 2025 (Inflammopharmacology)

Curcumin Kroon et al. 2025 (iScience)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Supported

“Meriva/Curcumin Phytosome delivers up to 29-fold greater bioavailability than unformulated curcumin”

This claim is directly and specifically supported by a peer-reviewed crossover pharmacokinetic study on the exact ingredient complex (Cuomo et al. 2011, PMID 21294203), which found approximately 29-fold higher plasma curcuminoid exposure versus unformulated curcumin. This is one of the more rigorously substantiated bioavailability claims in this comparison set.

Supported

“Supports joint comfort and mobility”

Two RCTs on the exact branded complex at a matching total daily dose (Belcaro et al. 2010, 3-month and 8-month) found substantial WOMAC osteoarthritis symptom score improvements and reduced concomitant pain-medication use. This is genuine product-level clinical support, though tempered by the fact that both trials come from the same overlapping research group and the ingredient manufacturer's (Indena) sponsorship/funding disclosures were not fully available in the reviewed abstracts.

Partial support

“Supports a healthy inflammatory response”

The cited CRP reduction in the Belcaro 2010 trial (from ~168 mg/L to ~11.3 mg/L) is a dramatic result, but the extremely high baseline CRP value is unusual for a general osteoarthritis population and raises a data-interpretation question this dossier could not fully resolve from the available abstract; the finding should be treated as suggestive rather than definitively established until the full paper's methodology can be independently reviewed.

Supported

“NSF Certified for Sport, verified free of banned substances and accurately labeled”

NSF Certified for Sport is a legitimate, independently audited third-party certification program with a public, searchable database of certified produkter; this is a verifiable, meaningful quality claim distinct from unverifiable brand-level marketing language.

Thorne HealthTech profile →

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

The full-text methodology and funding disclosures of the two Belcaro Meriva osteoarthritis trials (2010 3-month and 8-month studies) were not independently reviewed beyond abstracts in this research pass; the unusually high baseline CRP value reported (~168 mg/L) could not be independently reconciled or explained.
Whether Indena S.p.A. (the manufacturer of the Meriva ingredient) directly funded or was otherwise involved in the cited clinical trials is not clearly disclosed in the abstracts reviewed, this is a material sponsor-proximity consideration for a branded-ingredient trial series concentrated among a small number of overlapping investigators.
This dossier could not confirm whether Thorne's specific finished capsule (as opposed to the raw Meriva ingredient tested in the cited trials) has itself been independently third-party lab tested for curcuminoid potency by an outlet such as ConsumerLab or Labdoor.
The 2023-2024 European regulatory attention to curcumin-supplement-associated rare liver injury case reports was not verified to specifically name this Thorne product or the Meriva ingredient by name, and should be read as category-level regulatory context, not a product-specific safety finding.
Long-term (beyond 8 months) safety and efficacy data for daily use of this exact product were not located.
Reddit r/Supplements community forum

mixed sentiment

Community discussion exists, with positive comments about Meriva’s research and benefits alongside concerns about Thorne’s labeling and formulation clarity. No single Reddit thread is treated as a representative product review.

no direct URLchecked 2026-08-07
Amazon customers aggregator

An Amazon listing for this exact product was located. The product URL is not retained because marketplace listings can change.

no direct URLchecked 2026-08-07

Important to know

CurcuminProdukter with just 'turmeric extract' and no branded delivery system are not bioavailable. Ask for the specific bioavailability system.

Redaktionellt notes

Uses Indena's well-studied Meriva phytosome, one of the more credible curcumin delivery forms on the market; dose (1g phytosome/day) is mid-range for phytosome-form curcumin produkter.

In plain language

Why this scored this way

This Thorne HealthTech Curcumin Phytosome (formerly Meriva 500-SF) scores 7.8, making it a strong scorer. It delivers the full 1000.0mg trial dose of Curcumin with grade B evidence (promising human data, not yet comprehensive).

What drives the score up

Dose-evidence score of 8.0 reflects good alignment with trial doses.
Tested by independent lab (transparency 8.0).
Curcumin is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

No public analysintyg available for independent verification.
Limited consumer feedback (community score: 6.0).

Why you'd choose it

You want good value at $0.60/day.
You want Curcumin from a Thorne HealthTech product.
You want a tested by independent lab product.

Why you might skip it

You want a product with a publicly available CoA.

Go deeper

Where this sits

Actives inside

Curcumin

Kategori

Se alla in Antioxidant →

Varumärke

Jämför this product → Visit brand site →

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Curcumin Phytosome (formerly Meriva 500-SF) and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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