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NiaCel 400

NAD+ booster · Capsule (Niagen®) · 60 portioner#15 / 46 in NAD+ booster
7.0
Overall score · out of 10
7.0
Overall score · out of 10
Dose vs. studies5.5
Transparency9.5
Value9.0
Community9.0
Formulation5.0
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
Redaktionellt score, paid $0 No affiliate link Tested by independent lab Public analysintyg Sample received: No
How we scored this product Show the full breakdown
Composite How this 7.0 is built. 0.55 × 5.5 + 0.20 × 9.5 + 0.10 × 9.0 + 0.10 × 9.0 + 0.05 × 5.0 = 7.0 out of 10. Säkerhet caps applied after. 7.0
7.0 composite
Dose vs. studies55%5.5
Transparency20%9.5
Value10%9.0
Community10%9.0
Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

The NAD+ precursor with the strongest safety file and EU approval.

2 landmark RCTs · US: GRAS, NDI accepted · EU: Authorised Novel Food (Commission Reg 2020/16)

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
133% av studiedosen
Meets or exceeds the published effective dose
Cost at trial dose
$0.81/day at trial dose
What one effective daily dose actually costs
Transparency
9.5/10 · Public analysintyg (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No major red flags
Public analysintyg, tested by independent lab, dose within range
No safety, transparency, or dose concerns detected at this time.
Redaktionellt verdict

Quick verdict

7.0 / 10
Best for
Full trial dose, Public analysintyg
Avoid if
No major red flags
Full-dose status
Meets trial dose
Pris/month
$32
COA status
Public
Biggest caveat
No significant caveats at this time.
Nearest alternatives

The numbers

Pris
$65
per bottle · 60 portioner
Dose vs. research
Above trial dose 133%
of published effective dose
$ / day at studied dose
$0.81
what one effective daily dose costs
$ / g active
$2.55
per gram of active substance
Independently checked

Data verification

Pris
$65
Verified n/a
Dose
133% av studiedosen
Verified n/a
COA status
Public
Verified n/a
Bevisning grade
BC
Per-ingredient breakdown
BNR
CBetaine (TMG)
Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Bevisning
NR
The NAD+ precursor with the strongest safety file and EU approval.
400 mg 133% av studiedosen
300 mg
Betaine (TMG)
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
25 mg 1% av studiedosen
3000 mg
3.8 /5
Medium confidence
Rated on 3 platforms (3 sources, no structured review counts)
Source diversity: 69%
ConsumerLabExamine.comTrustpilot
PraisePassed ConsumerLab identity/purity testing in NAD+ precursor category.Examine lists NR as one of the best-validated NAD+ boosters, with an established
Last checked: 2026-08-07

Consumer signals

Consumer signals gathered from 3 platforms.

Medium confidence

Consumer sentiment compiled from 3 public sources (ConsumerLab, Examine.com, Trustpilot).

positive sentiment

PraisePassed ConsumerLab identity/purity testing in NAD+ precursor category.

Compiled from a ConsumerLab listing located during manual research; not independently re-verified against the live page at build time.

positive sentiment

PraiseExamine lists NR as one of the best-validated NAD+ boosters, with an established safety record.

Compiled from a Examine.com listing located during manual research; not independently re-verified against the live page at build time.

4.5/5 · positive sentiment

PraiseThorne brand-level 4.5/5. Cited for practitioner-grade quality.

Compiled from a Trustpilot listing located during manual research; not independently re-verified against the live page at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site
SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes
NIH DSLD registered label
DSLD ID 270802, UPC 6 93749 01208 5
Portionstorlek1 Capsule(s)
Portioner per container60
Supplement Facts panel, verbatim
Nicotinamide Riboside Hydrogen Malate415 mg
Betaine Anhydrous85 mg

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Healthline — best vitamin brands
Has affiliate relationship Not a paid placement

Names Thorne as category-leading on purity and third-party testing despite the operational Trustpilot score.

How we use it: Facts on purity certification accepted. Redaktionellt ranking treated with caution because Healthline runs affiliate links.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot — Thorne (aggregated sentiment)
No affiliate relationship Not a paid placement

Aggregate score 2.4 / 5. Complaints concentrate on delivery, billing, and customer service — not on product quality or purity.

Finding: 2.4 / 5. Complaints are operational, not product.
How we use it: Sentiment only. We explicitly separate operational scores from product-quality scores in our own model.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

ConsumerLab
positive

Passed ConsumerLab identity/purity testing in NAD+ precursor category.

Read source → Unverified · we received no payment for this listing
Examine.com
positive

Examine lists NR as one of the best-validated NAD+ boosters, with an established safety record.

Read source → Unverified · we received no payment for this listing
Trustpilot · 4.5
positive

Thorne brand-level 4.5/5. Cited for practitioner-grade quality.

Read source → Unverified · we received no payment for this listing

Vår sammanfattning

NiaCel 400 is Thorne's entry in the nicotinamide-riboside category, delivering 415 mg of an NR salt (nicotinamide riboside hydrogen malate) plus a small dose of betaine. The human research behind the ingredient class is real but modest: multi-week trials consistently show NR raises NAD+-related blood and, in one small study, muscle markers, with safety holding up even at doses above what's in this capsule. What those trials have not shown is a reliable, replicated functional benefit — grip strength, blood pressure, and exercise metabolism have all come back null or borderline in individual studies. No trial has been run on NiaCel 400 itself, and the salt form Thorne uses (NRHM) has essentially no standalone published human data of its own, unlike the NR chloride salt used in most of the cited studies. Buyers are, in effect, paying for a well-manufactured product built on borrowed ingredient-level science rather than product-specific proof.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 3Ingredient RCT (matching dose)
5 studies mapped
Tier 3Ingredient RCT (matching dose)
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Martens CR, Denman BA, Mazzo MR, et al. · 2018 · Nature Communications · n=24 · 500 mg NR chloride twice daily (1,000 mg/day total) · 6 weeks (2x6-week randomized, dubbelblind, placebokontrollerad crossover)
peer-reviewed
This is the trial most often cited for NiaCel-type produkter. Six weeks of NR raised blood NAD+ metabolites by roughly 60% and was well tolerated, with a non-significant trend toward lower systolic blood pressure and reduced arterial stiffness that only reached significance in a post-hoc subgroup with higher starting blood pressure. It is evidence that NR reliably raises a biomarker, not proof that it slows aging or reliably improves cardiovascular measures in unselected adults.
Dose (1,000 mg/day of NR chloride) is roughly 4x the elemental NR NiaCel 400 likely delivers, and uses a different salt form than Thorne's NRHM. Not run on Thorne's product.
Conflicts: None disclosed by Thorne; independently funded university research (Colorado).
Tier 3Ingredient RCT (matching dose)
An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers
Airhart SE, Shireman LM, Risler LJ, et al. · 2017 · PLoS ONE · n=8 · Escalating single doses from 250 mg up to 1,000 mg NR · 8 days of escalating doses (single-dose pharmacokinetics)
peer-reviewed
First human pharmacokinetic study of NR. Confirmed that oral NR is absorbed and safely raises whole-blood NAD+ in a dose-dependent way, with no serious adverse events across the 250-1,000 mg range. This is a safety and absorption study, not an efficacy trial — it does not test any health outcome.
Open-label with no placebo arm and only 8 participants — useful for safety, weak for efficacy claims. Not run on Thorne's product or NRHM salt specifically.
Conflicts: Academic study (University of Washington); not Thorne-funded.
Tier 3Ingredient RCT (matching dose)
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Elhassan YS, Kluckova K, Fletcher RS, et al. · 2019 · Cell Reports · n=12 · 1,000 mg/day NR · 21 days
peer-reviewed
Twenty-one days of NR raised NAD+ metabolites directly inside aged muscle tissue (not just blood) and shifted expression of some metabolic and anti-inflammatory genes. It found no improvement in hand-grip strength, muscle blood flow, glucose uptake, or measured mitochondrial function — the molecular signal did not translate into a measured functional or performance benefit in this small trial.
Dose close to what NiaCel 400 likely delivers in elemental terms is uncertain given the NRHM salt question; sample size is very small (n=12, one group).
Conflicts: Academic study (University of Birmingham); not Thorne-funded.
Tier 5Mechanistic / animal / marketing
No RCT on Thorne NiaCel 400 (or any NiaCel formulation) was identified
None · None
NO1GEVITY searched PubMed and ClinicalTrials.gov for any interventional trial naming NiaCel or run by Thorne on this specific NR + betaine capsule and found none. The clinical evidence Thorne's marketing leans on is entirely at the ingredient level (nicotinamide riboside broadly, mostly using ChromaDex's own chloride salt and clinical program), not on this finished formulation. Given that Thorne and ChromaDex were in active patent litigation over Thorne's use of NR in NiaCel and ResveraCel (2021-2024), it is unsurprising that ChromaDex's clinical program was never extended to validate Thorne's competing product.
This entry exists to make the absence explicit rather than let it go unstated. See also the ChromaDex/Dartmouth v. Thorne patent litigation entry under unverified/claim_check context.
Tier 5Mechanistic / animal / marketing
ChromaDex 2025 independent testing round of NR supplement brands
ChromaDex Corp. (testing organization) · 2025
not peer-reviewed
Reported secondhand via a supplement-review YouTube channel citing ChromaDex's 2025 test of 39 NR brands: most failed to meet label claims, but Thorne NiaCel 400 and Thorne ResveraCel were both reported as passing, with NiaCel 400 reportedly measuring about 475 mg of the labeled nicotinamide riboside compound per capsule. This is a label-accuracy check, not evidence the ingredient does anything — and NO1GEVITY has not located ChromaDex's original underlying report to confirm the exact methodology or figures, so this claim is treated as provisional.
Secondary source; original ChromaDex report not independently located.
Conflicts: ChromaDex is a commercial competitor to Thorne in the NR ingredient market, which is a notable conflict of interest for a brand-comparison test it conducted and publicized.
Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support
“NiaCel 400 helps defend the body against the effects of early aging by boosting NAD+”
NR reliably raises NAD+-related blood metabolites in multiple human trials (e.g., Martens 2018), which supports the mechanistic first half of the claim. There is no human trial demonstrating that this translates into a measurable anti-aging effect, and none of those trials were run on this product.
Not supported
“Supports athletic performance and exercise efficiency”
The closest relevant human data (Elhassan 2019) found no improvement in hand-grip strength or muscle blood flow after NR supplementation, and other published NR-and-exercise studies have generally found no change in exercise metabolism. NO1GEVITY found no trial showing an athletic-performance benefit for NR at any dose in healthy adults.
Supported
“NSF Certified for Sport”
This certification is independently verifiable and real; it confirms label accuracy and absence of banned substances, which NO1GEVITY treats as a manufacturing-quality signal, not an efficacy signal.

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

US
Legal as supplement
Marketed as a dietary supplement under DSHEA; NR chloride has an FDA-acknowledged GRAS notification, but Thorne's exact NRHM salt's individual regulatory filings were not independently verified.
Senast verifierad 2026-08-05
EU
Uncertain Novel Food Scope
Nicotinamide riboside chloride was authorized as an EU Novel Food in jan 2020, but that authorization carried a 5-year data-protection period naming ChromaDex Inc. as the sole authorized applicant. Thorne's NiaCel 400 uses NR hydrogen malate, a different salt form, and NO1GEVITY could not confirm a separate EU novel food authorization covering this specific salt. Treat EU legality of this exact product as unverified rather than assumed.
Senast verifierad 2026-08-05
UK
Uncertain Novel Food Scope
UK Food Standards Agency lists NR chloride (≥90% purity) as an authorised novel food at up to 300 mg/day; same salt-form caveat as the EU entry applies.
Senast verifierad 2026-08-05
CA
Uncertain
Health Canada requires a Natural Product Number (NPN) for market sale; NO1GEVITY did not find a confirmed active NPN listing specifically for Thorne NiaCel 400.
Senast verifierad 2026-08-05

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • The precise elemental NR content of the 415 mg NRHM dose on the current label — Thorne does not publish an elemental-NR conversion figure for this product.
  • Whether NiaCel 400 (this specific NRHM formulation) has a confirmed EU Novel Food authorization independent of ChromaDex's NR-chloride filing.
  • The exact methodology and full results of the 2025 ChromaDex brand-testing round referenced only via a secondary video source.
  • Whether Thorne has a public, batch-specific, downloadable Certificate of Analysis for this exact SKU (the company describes internal testing but NO1GEVITY could not locate a public per-batch CoA on thorne.com for NiaCel 400).
  • Reddit r/Supplements community forum
    positive sentiment

    Community discussion exists and is predominantly positive, highlighting perceived benefits and lower cost compared with Tru Niagen. No single Reddit thread is treated as a representative product review.

    no direct URLchecked 2026-08-07
  • Thorne on-site reviews own platform

    The product page is a first-party page with customer-review presentation, but no product rating or count was extracted.

    verified 2026-08-07Open source →
  • Amazon customers aggregator

    An Amazon listing for this exact product was located. The product URL is not retained because marketplace listings can change.

    no direct URLchecked 2026-08-07
Important to know
NRAlmost all commercial NR uses licensed Niagen® from ChromaDex. If a product doesn't say Niagen, ask why.
Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination produkter) are well below the gram-level doses used in the supporting human trials.

Redaktionellt notes

Best-price licensed Niagen® NR product on the market. NSF Certified for Sport.

In plain language

Why this scored this way

This Thorne HealthTech NiaCel 400 scores 7.0, making it a mid-tier product with both strengths and weaknesses. It delivers the full 400mg trial dose of NR with grade B evidence (promising human data, not yet comprehensive). Transparency is a clear strength (score: 9.5), with third-party testing and a public analysintyg.

What drives the score up

  • Quality transparency of 9.5: tested by independent lab with a public analysintyg.
  • Community score of 9.0 with positive consumer feedback.
  • NR is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

  • Dose-evidence score of 5.5 is below average for the site.
  • Betaine (TMG) (25mg is 1% of the 3000mg trial dose) is significantly under-dosed.

Why you'd choose it

  • You want a reasonably priced nad+ booster product.
  • You want NR from a Thorne HealthTech product.
  • You prioritise tested by independent lab produkter with public lab certificates.

Why you might skip it

  • You need a full trial dose of betaine (this product under-doses it).
Go deeper

Where this sits

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of NiaCel 400 and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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