Tru Niagen 300 mg

Martens et al. 2018 Dellinger et al. 2017

Tru Niagen 300 mg

Name: Tru Niagen 300 mg
Brand: Tru Niagen (ChromaDex)
SKU: tru-niagen-300
Price: 45.0 USD
Availability: InStock
Rating: 4.38 (2 reviews)

NAD+ booster · Capsule (Niagen®) · 30 portioner#2 / 46 in NAD+ booster

8.0

Overall score · out of 10

8.0

Overall score · out of 10

Dose vs. studies8.0

Transparency8.0

Value8.0

Community9.0

Formulation5.0

Tier 3

Ingredient RCT (matching dose)

The ingredient was tested in an RCT at the same dose this product sells.

Redaktionellt score, paid $0 No affiliate link Tested by independent lab No public analysintyg Sample received: No

How we scored this product Show the full breakdown

Dose vs. studies (55%) 8.0

Transparency (20%) 8.0

Value (10%) 8.0

Community sentiment (10%) 9.0

Formulation (5%) 5.0

Composite 8.0

8.0 composite

Dose vs. studies55%8.0

Transparency20%8.0

Value10%8.0

Community10%9.0

Formulation5%5.0

Bevisning gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Säkerhet caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

NR Grade B

The NAD+ precursor with the strongest safety file and EU approval.

2 landmark RCTs · US: GRAS, NDI accepted · EU: Authorised Novel Food (Commission Reg 2020/16)

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

100% av studiedosen

Meets or exceeds the published effective dose

Cost at trial dose

$1.50/day at trial dose

What one effective daily dose actually costs

Transparency

8.0/10 · No public analysintyg

Independent batch testing confirmed

Consumer signals

2 reviews across platforms · 4.4/5 · medium confidence

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Säkerhet flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No public analysintyg

Certificate of Analysis not published

Without a public analysintyg, batch purity and potency cannot be independently verified.

Best for

Full trial dose

Avoid if

No public analysintyg

Full-dose status

Meets trial dose

Pris/month

$45

COA status

Not public

Biggest caveat

No public Certificate of Analysis.

Nearest alternatives

Nicotinamide Riboside Capsules Nootropics Depot · Poäng 8.0
NAD+ Cell Regenerator (NIAGEN Nicotinamide Riboside, 300mg standalone) Life Extension · Poäng 7.8
NR (Nicotinamide Riboside, Liposomal) 300mg Renue By Science · Poäng 7.6

The numbers

Pris

$45

per bottle · 30 portioner

Dose vs. research

Överensstämmer med studier 100%

of published effective dose

$ / day at studied dose

$1.50

what one effective daily dose costs

$ / g active

$5.00

per gram of active substance

Independently checked

Data verification

Pris

$45

Verified n/a

Dose

100% av studiedosen

Verified n/a

COA status

Not public

Verified n/a

Bevisning grade

Per-ingredient breakdown

BNR

Verified n/a

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Bevisning grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Bevisning

The NAD+ precursor with the strongest safety file and EU approval.

300 mg 100% av studiedosen

300 mg

3.7 /5

Medium confidence

Rated on 3 platforms (3 sources, no structured review counts)

Source diversity: 69%

Examine.comLabdoorTrustpilot

PraiseLabdoor NAD+ ranking: Tru Niagen top-3 for identity and purity.Examine highlights Niagen® NR as the most heavily-studied NAD+ booster in humans

Last checked: 2026-08-07

Consumer signals

4.38 out of 5 across 2 verified reviews on 3 platforms.

Medium confidence

Consumer sentiment compiled from 3 public sources (Examine.com, Labdoor, Trustpilot).

Labdoor

4.35/5 · positive sentiment

PraiseLabdoor NAD+ ranking: Tru Niagen top-3 for identity and purity.

Compiled from a Labdoor listing located during manual research; not independently re-verified against the live page at build time. Rating converted from 100-point to 5-point scale.

Examine.com

positive sentiment

PraiseExamine highlights Niagen® NR as the most heavily-studied NAD+ booster in humans.

Compiled from a Examine.com listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

4.4/5 · positive sentiment

Praise4.4/5. Users like the safety data; occasional complaints about auto-ship.

Compiled from a Trustpilot listing located during manual research; not independently re-verified against the live page at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Innerbody

Has affiliate relationship Not a paid placement

Cautiously positive: Innerbody's medically-reviewed staff assessment concludes Tru Niagen is a well-researched, FDA-acknowledged-safe NR supplement, but flags an unresolved, contested theoretical concern about NR potentially exacerbating tumor growth in cancer patients (citing mixed preclinical evidence) and recommends physician consultation for anyone with a cancer history.

Finding: Reports that 8 weeks of NR supplementation at the Tru Niagen dose can raise NAD+ by over 50%, citing published trial data; notes the product's 300 mg dose 'should be enough for most people' but flags that some trials used doses up to 1,000 mg, raising the possibility that 300 mg is insufficient for some users.

How we use it: Used as a Tier A source for both the NAD+ percentage claim context and as the source of the most balanced independent safety caveat (cancer-risk theoretical concern) found in this review. Innerbody discloses its affiliate revenue model and its own staff testing/Medical Review Board methodology, which meets the Tier A bar of disclosed methodology despite the affiliate relationship.

ConsumerLab

No affiliate relationship Not a paid placement

ConsumerLab's independent lab testing supports that the genuine Tru Niagen product meets its label claim for NR content, in contrast to a majority of competing NR supplements tested in the same sweep, but the existence of counterfeit Tru Niagen produkter in the market is a real risk ConsumerLab has flagged for buyers purchasing outside official channels.

Finding: States one Tru product was tested and reviewed by ConsumerLab and is 'Approved for quality'/'Top Picks' status; separately reports that in a broader category sweep, 29 of 39 tested NR supplements contained much less NR than claimed (some under 1%), and that counterfeit versions of Tru Niagen have been identified in the market.

How we use it: Treated as the strongest independent quality-testing signal available; used to support the quality_certifications assessment. Full numeric findings (exact measured NR content) are behind ConsumerLab's paywall and were not directly accessed, so exact figures are marked unverified rather than stated as fact.

Healthline

No affiliate relationship Not a paid placement

General ingredient-level review (not a product-specific test) concluding NR is a reasonably well-tolerated vitamin B3 form marketed for anti-aging purposes, with mild possible side effects (nausea, fatigue, headache, GI discomfort) reported by some users, and with benefits still considered unproven for humans despite promising animal data.

Finding: States NR is 'likely safe with few, if any, side effects'; notes human studies using 1,000 mg/day found no harmful effects, and reports most NR supplement brands (Tru Niagen included, sold under the Niagen ingredient name) recommend 250-300 mg/day.

How we use it: Used as ingredient-level, editorially-independent context (not a hands-on product test) to corroborate the 300 mg dose being within the typical commercial and studied range, and to source the standard side-effect profile. This is an ingredient overview rather than a Tru Niagen product review, so it is used only for background dosing/safety context, not for product-specific claims.

Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot (US)

No affiliate relationship Not a paid placement

Mixed-to-negative sentiment, but the sample size (N=10) is far too small to be statistically meaningful and falls well below the brief's N>500 threshold for Tier B treatment of Trustpilot data.

Finding: 2.9 out of 5 stars, based on only 10 reviews; one review describes an unwanted recurring subscription charge.

How we use it: Downgraded to Tier C due to the very small review count; reported only as a directional data point alongside the larger but separately caveated Amazon rating, not as a reliable independent verdict on the product.

Trustpilot (UK)

No affiliate relationship Not a paid placement

Middling independent sentiment from UK customers, with one favorable review specifically citing lowered cholesterol and blood pressure alongside no side effects, an individual anecdote, not a controlled measurement.

Finding: Rated 'Average' at 3.1 out of 5 stars; sample size not confirmed in this review pass (direct fetch blocked by the site's robots.txt, so figures are taken from search-engine snippets rather than a directly rendered page).

How we use it: Reported as directional-only, Tier C, both because the sample size could not be confirmed and because the page could not be directly fetched (robots.txt disallow), figures rely on third-party search snippets rather than a primary-source rendering.

Amazon customer reviews

No affiliate relationship Not a paid placement

Large sample size skews positive, consistent with typical Amazon supplement review patterns, but Amazon reviews are known to be susceptible to incentivized/manipulated reviews and lack any testing methodology; one critical review specifically noted a subtle, hard-to-notice effect relative to the product's price.

Finding: 4.4 out of 5 stars based on 13,161 global ratings.

How we use it: Cited only as a large-N directional signal, explicitly caveated for known Amazon review-manipulation risk and absence of any methodology; not used to support or contradict any specific health claim.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Labdoor · 87

positive

Labdoor NAD+ ranking: Tru Niagen top-3 for identity and purity.

Read source → Unverified · we received no payment for this listing

Examine.com

positive

Examine highlights Niagen® NR as the most heavily-studied NAD+ booster in humans.

Read source → Unverified · we received no payment for this listing

Trustpilot · 4.4

positive

4.4/5. Users like the safety data; occasional complaints about auto-ship.

Read source → Unverified · we received no payment for this listing

Vår sammanfattning

Tru Niagen 300mg delivers 300 mg of NIAGEN nicotinamide riboside chloride per capsule, a patented NAD+ precursor ingredient exclusively licensed and supplied by its maker, Niagen Bioscience (formerly ChromaDex). Its strongest evidentiary support is Conze et al. 2019 (https://pubmed.ncbi.nlm.nih.gov/31278280/), an 8-week, placebokontrollerad trial that tested this exact 300 mg/day dose and found a 48-51% sustained rise in whole-blood NAD+ with no significant safety signal versus placebo, a genuine ingredient-dose match, though it was a company-funded trial on a biomarker endpoint rather than an independent trial on a clinical outcome. Higher-dose trials (Martens 2018, Elhassan 2019) support the ingredient's broader safety profile up to 1,000 mg/day but used 3x this product's dose and found more modest or mixed effects on harder outcomes like blood pressure, muscle NAD+, and grip strength. Buyers should know that NR (this ingredient) is legally and regulatorily distinct from NMN, it has clean US GRAS/NDI status and EU Novel Food authorization at exactly this 300 mg dose, and that independent lab testing (ConsumerLab) supports the genuine product's label accuracy, but the product's evidence ceiling is an ingredient-level RCT at matching dose (Tier 3), not a trial on the finished capsule itself.

Bevisning, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 3Ingredient RCT (matching dose)

3 studies mapped

Tier 3Ingredient RCT (matching dose)

Säkerhet and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

Conze D, Brenner C, Kruger CL · 2019 · Scientific Reports · n=140 · 100 mg, 300 mg, or 1000 mg NR per dag (three active arms vs. placebo) · 8 weeks

ingredient-levelpeer-reviewed

Dose-dependent, statistically significant increases in whole-blood NAD+ within 2 weeks (22%, 51%, and 142% at 100/300/1000 mg respectively), sustained through 8 weeks (10%, 48%, 139% vs. baseline); no flushing; no significant difference in adverse events vs. placebo at any dose; no LDL cholesterol elevation; no dysregulation of 1-carbon metabolism.

This is the only one of the three priority trials that tested the exact 300 mg/day dose used in this product, making it a direct ingredient-dose match. However, it measured a biomarker (whole-blood NAD+) rather than a clinical health outcome, and it was funded and staffed by ChromaDex employees (see conflicts below) and conducted on the finished-ingredient supplier's own product, not an independently manufactured comparator.

Conflicts: Studie funded by ChromaDex. Författare Claire Kruger and Dietrich Conze were ChromaDex employees at the time of the study (Chromadex Spherix Consulting); co-author Charles Brenner is the inventor of intellectual property licensed by ChromaDex and served as the company's chief scientific adviser, per the paper's own conflict-of-interest statement.

Source →

Tier 4Ingredient RCT (different dose)

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR · 2018 · Nature Communications · n=24 · 500 mg twice daily = 1,000 mg/day NR (NIAGEN) · 2 x 6-week randomized, dubbelblind, placebokontrollerad crossover

ingredient-levelpeer-reviewed

NAD+ in peripheral blood mononuclear cells increased roughly 60%; well tolerated with no serious adverse events; trend toward reduced systolic blood pressure and arterial stiffness in participants with elevated baseline blood pressure; no significant change in other metabolic markers.

Dose tested (1,000 mg/day) is more than 3x the 300 mg label dose of this product, so this trial supports the ingredient's safety and NAD+-raising mechanism at a higher dose, not the exact dose sold here. Författare declared no competing interests.

Conflicts: None identified; authors declared no competing interests in the published paper. Funded by NIH grants (P30 DK048520, T32 AG000279, UL1 TR001082).

Source →

Tier 4Ingredient RCT (different dose)

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG · 2019 · Cell Reports · n=12 · 1,000 mg/day (1 g/day) NR · 21-day treatment, 21-day washout, placebokontrollerad, randomized, dubbelblind, crossover

ingredient-levelpeer-reviewed

Muscle NAAD (a NAD+ metabolite) roughly doubled and blood NAAD increased 4.5-fold, but muscle NAD+ itself did not significantly increase; NR downregulated energy-metabolism/mitochondrial genes without altering measured mitochondrial bioenergetics; circulating inflammatory cytokines (IL-6, IL-5, IL-2) fell by roughly 50-70%; no significant change in grip strength, blood flow, blood pressure, body weight, or lipids.

Dose (1,000 mg/day) is more than 3x this product's 300 mg label dose, and the small sample (N=12) limits statistical power. Notably, the trial did NOT find a significant increase in muscle NAD+ itself despite the NAD+ metabolome shift, a more cautious result than headline NAD+-boosting marketing claims imply.

Conflicts: Co-author Charles Brenner is the inventor of patents licensed by ChromaDex, owns ChromaDex stock, and serves as an adviser to ChromaDex, per the paper's own disclosure. Remaining authors declared no competing interests. Funded by the Wellcome Trust, Medical Research Council (UK), and NIH.

Source →

Bevisning

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

NR Martens et al. 2018

NR Dellinger et al. 2017

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support

“Tru Niagen boosts NAD+ levels by over 50%”

Supported for the biomarker claim specifically at 2 weeks: Conze et al. 2019 found a 51% increase in whole-blood NAD+ at the 300 mg dose within 2 weeks (https://pubmed.ncbi.nlm.nih.gov/31278280/), though by 8 weeks the sustained increase at 300 mg was measured at 48%, slightly under the '50%+' framing. The claim is accurate for a blood biomarker but does not demonstrate any downstream clinical health benefit, NAD+ elevation is a surrogate marker, not a proven outcome.

Unverifiable

“NIAGEN is featured in more than 65% of registered, ongoing, or completed clinical trials on nicotinamide riboside”

This is a vendor-stated statistic about the broader NR research landscape that we could not independently confirm against a live, dated ClinicalTrials.gov query in this review pass. It is plausible given ChromaDex/Niagen Bioscience's history of supplying NIAGEN to academic researchers, but the specific percentage figure has no independently published source.

Partial support

“Extensively studied and shown to be both safe and effective when taken as directed”

Säkerhet at doses up to 1,000 mg/day is well-supported across multiple RCTs (Conze 2019, Martens 2018, Elhassan 2019) with no serious adverse events reported. 'Effective' is true narrowly for raising blood NAD+ levels, but the same trials found limited or no effect on harder clinical endpoints, Elhassan 2019 found no significant increase in muscle NAD+ itself and no change in grip strength or blood pressure; Martens 2018 found only a trend (not definitive) toward lower blood pressure. A 2023 independent review (https://pmc.ncbi.nlm.nih.gov/articles/PMC10361580/) concluded that oral NR supplementation in humans 'has displayed few clinically relevant effects' beyond biomarker changes and modest anti-inflammatory signals.

Supported

“The FDA acknowledges its safety”

Confirmed: FDA issued a GRAS 'no objection' letter for NIAGEN at 180 mg/day in 2016 (GRN 635, https://www.fda.gov/files/food/published/GRAS-Notice-000635--Nicotinamide-riboside-chloride.pdf) and accepted New Dietary Ingredient notifications at 180 mg/day (2015) and 300 mg/day (2018, https://downloads.regulations.gov/FDA-2018-S-0023-0033/content.pdf). This is a real regulatory 'no objection' status, though it is not equivalent to FDA 'approval' of health claims or efficacy.

Se alla in NAD+ booster →

Regelverk status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

No public, batch-level Certificate of Analysis was located on the vendor's site for this specific 30-count 300mg SKU during this review.
The vendor's claim that NIAGEN 'is featured in more than 65% of registered, ongoing, or completed trials on nicotinamide riboside' could not be independently verified against a live ClinicalTrials.gov search in this pass.
Exact manufacturing location/facility for the finished capsule (as opposed to the NIAGEN raw ingredient, which is manufactured by W.R. Grace) was not confirmed.
ConsumerLab's full test results for this specific product (exact measured NR content vs. the 300 mg label claim) sit behind a paywall; only summary/secondary-source figures (reportedly ~303 mg found vs. 300 mg labeled) were available, and could not be verified against the primär ConsumerLab report in this pass.
The vendor's on-site customer survey (92% agree the product is important to their healthy-aging journey, 85% would recommend it, based on n=118 self-selected respondents at https://www.truniagen.com/pages/reviews) is a marketing-controlled data source, not an independent survey, and should not be treated as equivalent to independent review platforms.
Direct fetch of the primär vendor product page (https://www.truniagen.com/produkter/tru-niagen-30-count-300mg/) timed out during this review; label and pricing data were cross-verified via retailer listings and vendor subdomains (support.truniagen.com, pages.truniagen.com, pro.truniagen.com) instead of the primär page rendering directly.
Trustpilot aggregator

2.9/510 reviews

This is a brand-level customer-service profile for tru-niagen; it does not isolate Tru Niagen 300 mg.

verified 2026-08-07Open source →
Reddit r/Supplements community forum

mixed sentiment

Community discussion exists around Tru Niagen, with reports of improved energy and recovery alongside concerns about high dosing and cost. No single Reddit thread is treated as a representative product review.

no direct URLchecked 2026-08-07
Tru Niagen on-site testimonials own platform

The public Tru Niagen page presents customer testimonials but no aggregate rating or count.

verified 2026-08-07Open source →

Important to know

NRAlmost all commercial NR uses licensed Niagen® from ChromaDex. If a product doesn't say Niagen, ask why.

Redaktionellt notes

The ChromaDex flagship. Extensive safety file, marketed heavily at the general consumer.

In plain language

Why this scored this way

This Tru Niagen (ChromaDex) Tru Niagen 300 mg scores 8.0, making it a strong scorer. It delivers the full 300mg trial dose of NR with grade B evidence (promising human data, not yet comprehensive). At $1.50/day it's among the more expensive options in NAD+ booster.

What drives the score up

Dose-evidence score of 8.0 reflects good alignment with trial doses.
Tested by independent lab (transparency 8.0).
Community score of 9.0 with positive consumer feedback.
NR is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

No public analysintyg available for independent verification.

Why you'd choose it

You want a reasonably priced nad+ booster product.
You want NR from a Tru Niagen (ChromaDex) product.
You want a tested by independent lab product.

Why you might skip it

You want a product with a publicly available CoA.
You want better value (this is $1.50/day with a value score of 8.0).

Go deeper

Where this sits

Actives inside

Kategori

Varumärke

Tru Niagen (ChromaDex) profile →

Jämför this product → Visit brand site →

Varumärke owners

Spot an error?

If you are the manufacturer or brand owner of Tru Niagen 300 mg and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primär sources, and publish any change with a dated note in the version history above. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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