Studie
Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea.
N=78: plasma LL-37 was 47.1 ng/L at AHI >= 15 vs 75.3 ng/L at AHI < 15 — a biomarker association, not an LL-37 intervention.
Observational study in 78 participants (58 obstructive sleep apnea patients, 20 healthy controls). Plasma LL-37 measured 75.3 +/- 29.3 ng/L in the AHI < 15 group vs 47.1 +/- 18.3 ng/L in the AHI >= 15 group — roughly 37% lower with more severe apnea. LL-37 correlated negatively with age, %Stage N1 sleep, arousal index, AHI and oxygen desaturation index, and positively with %Stage N3, %REM, mean SpO2 and minimum SpO2. Multiple regression identified %Stage N1 as the independent predictor. No intervention, no dosing. This is endogenous-biomarker work: it says nothing about LL-37 supplementation.
Plasma LL-37 tracks sleep fragmentation and desaturation severity in obstructive sleep apnea.
Observational, no intervention. No correlation coefficients or p-values in the abstract. Biomarker association only.
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