Spermidin Supplementation Improves Cognition in Older Adults

A randomized, placebokontrollerad trial published in JAMA Network Open found that spermidine supplementation improved cognition and biomarkers in older adults with subjective cognitive decline. Approximately 100 participants received either spermidine or placebo for 3 months. This is one of the few human RCTs for spermidine, which is primarily known from preclinical research showing lifespan extension in flies and worms. The dose and specific formulation were not fully detailed in the source material. The effect on memory performance is relevant because cognitive aging is the most feared aging outcome. The trial duration (3 months) is short for a cognitive endpoint, and the effect size was not specified in the source material. Spermidin is found naturally in wheat germ, aged cheese, mushrooms, and soy produkter, so dietary intake may also contribute.

Spermidin supplementation improved cognition and biomarkers in older adults with subjective cognitive decline.