Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, dubbelblind, placebokontrollerad trial.

En sexarmad randomiserad studie med 103 äldre (medelaldern 68,2 år) visade att 16 veckors hastighetsträning förbättrade markstyrka och gånghastighet markant, jämfört med kontrollgruppen. The outcome list was broad: brain-derived neurotrophic factor, oxidative and inflammatory markers, strength, handgrip, timed up-and-go, chair stands, 6-minute walk, trail making, and SF-36 quality of life. The abstract reports significant improvements across both training modalities in neurocognitive biomarkers, oxidative and inflammatory profiles, strength, function, cognition, and quality of life. It also states that aquatic training was particularly effective for oxidative stress and inflammation and that creatine gave complementary, modality-specific benefits. However, the results section supplies no numerical effects, p-values, or arm-by-arm comparisons. That prevents a clear estimate of what 3 g/day of creatine added beyond training. The findings support exercise in older adults more directly than they support a standalone creatine claim.

Creatine supplementation confers complementary, modality-specific benefits when combined with high-speed resistance exercise.