Examining the feasibility and preliminary effects of resistance exercise training and creatine supplementation in individuals treated for colorectal cancer.

Denna pilotstudie undersökte om kreatinmonohydrat kunde läggas till ett hybridprogram med styrketräning för personer som tidigare behandlats för tjock- och ändtarmscancer. Twenty-seven participants were randomised to resistance exercise plus 5 g/day creatine monohydrate (n=13) or the same exercise programme plus 5 g/day corn-starch maltodextrin placebo (n=14). Training was prescribed three times weekly for 10 weeks, with in-clinic and virtual sessions. Recruitment was difficult: 27 of 410 assessed people enrolled, or 6.6%, despite 1,378 potentially eligible people being identified through the registry. Retention was 24/27 (88.9%), and adherence to both training and supplementation exceeded 85%. No serious adverse events were reported, and participants rated the programme highly acceptable. Secondary outcomes included body composition, strength and physical function. No significant between-group differences were observed. Both groups had modest improvements in muscular strength and Short Physical Performance Battery scores. The useful finding is practical rather than proof of a creatine effect: supervised hybrid training was feasible in this clinical group, while creatine did not produce a clear additional improvement.

Creatine supplementation did not demonstrate clear additive effects in this pilot trial.