12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomiserad kontrollerad studie.

Fyrtiofyra vuxna män med fetma fullföljde en 12 veckor lång randomiserad studie med fyra grupper: placebo, enbart fisetin, kombinerad intervallbaserad styrke- och konditionsträning med placebo eller samma träning med fisetin. Fisetin gavs i dosen 200 mg/dag. Training combined eight resistance exercises at 60% of one-repetition maximum with progressive aerobic work at 50% to 70% of maximum heart rate. The study measured Maresin-1, IL-6, TNF-α, fasting blood glucose, insulin, and HOMA-IR before and after treatment. Group-by-time interactions were reported for every listed marker: Maresin-1 p=0.034, and IL-6, TNF-α, glucose, insulin, and HOMA-IR each p=0.001. Maresin-1 rose in both training groups. IL-6 fell with training, training plus fisetin, and fisetin alone; TNF-α fell in all active groups. Glucose, insulin, and HOMA-IR declined in all active arms, with the largest reductions in the combined training-fisetin group. The abstract does not give the size of those reductions or direct pairwise comparisons. This is a short metabolic-biomarker study in obese men, not evidence of disease prevention or longer life.

Twelve weeks of concurrent interval resistance-aerobic training, especially when combined with fisetin, improved inflammatory and metabolic markers in obese men.