Omega-3 fatty acids and tear cytokines modulation in dry eye patients with low omega-3 index. Have the beneficiaries been pinpointed?

Forskarna randomiserade 102 personer med torra ögon och ett omega-3-index under 4 %. Deltagarna fick omega-3-kapslar eller olivoljeplacebo två gånger dagligen i sex månader. Varje omega-3-kapsel innehöll 325 mg eikosapentaensyra och 175 mg dokosahexaensyra; deltagarna tog fyra kapslar vid varje doseringstillfälle. The primär endpoint was tear cytokines, including IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-gamma and TNF-alpha. Secondary assessments included symptoms, Nelson grade, goblet-cell density, Schirmer test values and tear-film breakup time. At baseline, impression cytology found raised IL-1beta, IL-6, IL-8 and TNF-alpha mRNA in both groups, with no between-group difference stated (p=0.123). The supplied abstract text is truncated in the results section, so it does not provide the specific cytokine changes, their p-values, or the secondary-outcome results. Its conclusion states that supplementation decreased tear inflammatory cytokines in this selected dry-eye population. That is a local biomarker result, not evidence of a systemic longevity effect. The low baseline omega-3 index also limits how directly this result applies to people with adequate omega-3 status.

Omega-3 fatty acid supplementation decreased tear inflammatory cytokines in dry-eye patients with an omega-3 index below 4%.