Effect of different sources of saturated and polyunsaturated fatty acids on postprandial inflammation: A dubbelblind randomized crossover trial.

Denna dubbelblinda randomiserade överkorsningsstudie med fyra behandlingsperioder testade akuta inflammatoriska svar på måltider med olika fettkällor. Arton friska vuxna åt testmåltider med samma energiinnehåll på 706 kcal och 40 g fett från smör, kokosolja, linfröolja eller majsolja. Blod samlades in under sex timmar efter varje måltid. The investigators measured inflammatory proteins with a proximity extension assay, while glycoprotein acetyls and triglycerides were measured by NMR spectroscopy. Across all meal challenges, 21 of 93 measured proteins, or 23%, changed after eating. The supplied abstract truncates part of the results, so it does not give all individual protein estimates or p-values. Its conclusion is clear: no consistent directional pattern favoured a particular fat source. Polyunsaturated-fat-rich meals produced slightly stronger inflammatory responses than saturated-fat-rich meals, but the overall influence of fat source was modest. This study concerns a single high-fat meal and transient blood markers. It does not test omega-3 supplementation, long-term dietary change, clinical disease outcomes, or longevity. The crossover design controls some between-person variation, but the sample remains very small and the endpoint is an acute surrogate response.

Fat source had a modest influence on postprandial inflammation, with no consistent directional pattern favouring a specific source.