Effect of different sources of saturated and polyunsaturated fatty acids on postprandial inflammation: A dubbelblind randomized crossover trial.

En dubbelblind randomiserad fyrvägs-crossoverstudie testade akuta inflammatoriska svar efter måltid med linfröolja och majsolja hos 18 friska vuxna. Ingen konsekvent effekt hittades. The investigators measured inflammatory proteins with a proximity extension assay, while glycoprotein acetyls and triglycerides were measured by NMR spectroscopy. Across all meal challenges, 21 of 93 measured proteins, or 23%, changed after eating. The supplied abstract truncates part of the results, so it does not give all individual protein estimates or p-values. Its conclusion is clear: no consistent directional pattern favoured a particular fat source. Polyunsaturated-fat-rich meals produced slightly stronger inflammatory responses than saturated-fat-rich meals, but the overall influence of fat source was modest. This study concerns a single high-fat meal and transient blood markers. It does not test omega-3 supplementation, long-term dietary change, clinical disease outcomes, or longevity. The crossover design controls some between-person variation, but the sample remains very small and the endpoint is an acute surrogate response.

Fat source had a modest influence on postprandial inflammation, with no consistent directional pattern favouring a specific source.