Krill oil increases plasma omega-3 fatty acids more than fish oil in healthy adults: a dubbelblind randomiserad kontrollerad studie.

Denna dubbelblinda randomiserade studie jämförde krillolja med fiskolja hos 72 friska vuxna, varav 53 kvinnor och 19 män. Trettiosex deltagare fick vardera produkt i 12 veckor. Båda grupperna fick 1,1 g/dag omega-3-fettsyror. Plasma EPA and DHA were measured at baseline and after 1, 2, 4 and 12 weeks.

Krill oil produced about 1.5-fold greater increases from baseline in plasma EPA and DHA than fish oil. The time-by-treatment interaction was significant for EPA, p = 0.0001, and DHA, p = 0.005. Sex modified the EPA response: women had a 1.5-fold larger increase than men at week 12, with p = 0.026 for the time-by-sex interaction. APOE4 carriers increased EPA threefold and DHA 1.6-fold from baseline after either supplement, but their changes were not significantly different from those of non-carriers.

This is a bioavailability study. It establishes different plasma fatty-acid responses at the stated dose, not superiority for cardiovascular events, cognition, symptoms or lifespan. The abstract does not report clinical outcomes. Its inference that lower krill-oil doses may achieve adequate enrichment is based on plasma measurements, not on demonstrated health effects.

Krill oil increased plasma omega-3 fatty acids more than fish oil regardless of APOE4 genotype.